Differences in Molecular Pathologic Characteristics of Pancreatic Adenocarcinoma between Egyptian and Moroccan Patients
Message:
Abstract:
Introduction
Pancreatic cancer has not been well studied, especially in developing countries.
Materials And Methods
We studied the variations in genetic mutations inpancreatic adenocarcinoma between Moroccan and Egyptian populations. Themolecular pathology of 30 tumors from a large hospital in Casablanca, Morocco wereexamined and compared with the findings of 44 tumors from the Gharbiah Governatein Egypt. K-ras mutations in codons12 and 13 in addition to p53 mutations in exons5-8 were evaluated.
Results
Overall, differences in the rates of K-ras mutations were not statisticallysignificant (48.00 and 34.09%, respectively); however differences in rates of p53mutations were statistically significant with p53 mutations more common in Moroccantumors than in Egyptian tumors (46.67 and 16.28%, respectively). GT mutations ofthe K-ras gene were most commonly seen Egyptian tumors, whereas GAmutationswere the most common type of mutations in Moroccan tumors. Logistic regressionanalysis showed that a p53 mutation in any exon as well as a p53 mutation in exon 5predicted the country of residence and those mutations occurred more frequently inMoroccan patients.
Conclusion
Our study shows that differences exist within the Arab population inthe molecular pathology of both the K-ras and p53 genes. Further studies are necessaryto clarify the differences in molecular pathways of pancreatic cancer in the Middle Eastand to investigate the role of environmental and/or genetic factors related to thosepathways
Language:
English
Published:
Middle East Journal of Cancer, Volume:1 Issue: 1, Jan 2010
Page:
27
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