Effects of humor therapy on fatigue and depression of multiple sclerosis (MS) patients

Multiple sclerosis (MS) is the most common disabling condition in young adults, which is caused by an inflammatory demyelination process in central nervous system. Fatigue and depression are the primary symptoms leading to dysfunction as well as disability in activities of daily living and decreased quality of life. Because of many drug-associated complications, applying other methods to lessen the symptoms seems reasonable. The aim of this study was to determine the effects of humor on fatigue and depression of clients referring to Iranian MS Society.In this one-group before-after clinical trial, 30 MS clients were selected by convenience sampling method. A 4-part questionnaire including demographics, items related to the condition, Fatigue Severity Scale (FSS) and Beck's Depression Inventory was used for data collection, validated and made reliable by content and test-retest methods respectively. The clients took part in humor therapy sessions 3 times a week, each lasting 30 minutes for 12 weeks. The sessions were hold during the day with entertaining and funny programs recorded on compact discs (CDs). The clients completed the questionnaire before and after the intervention. Data were then analyzed by different statistical methods. A significant decrease was found in mean severities of fatigue and depression after the intervention (P