The Comparison of Quantitative 8 and 24 Hour Urine Protein Samples for Diagnosis of Preeclampsia

Introduction Preeclampsia, clinically recognized by gestational hypertension with proteinuria,occurs after 20 week's gestation is a leading cause of maternal and perinatal morbidity and mortality. Early diagnosis to prevent maternal and fetal complications is important. The gold standard for proteinuria, is a 24-hour urine sample for total protein. The purpose of this study was to compare the urine protein in the 8 –hour Sample with the 24-hour Sample Urine Profein to diagnose of preeclampsia.Materials and MethodsThe study population included 76 inpatients with hypertensive disorders of pregnancyduring 2009 and 2010. Patient's urine was collected over 24 hours with the first 8 hours, next 16 hours, in separate containers. The urine volume and total protein and creatinine levels were measured in the 8 and 24 hour samples. The results of 8 and 24-hour Sample were compared by useing of SPSS software Win PePi 1.45. The correlation between 8 and 24-hour tests was evaluated using Pearson and Spearman correlation coefficients.Of the 76 patients 18 cases had no proteinuria, 53 had mild proteinuria and 5 had severe pro-teinuria.Resultsprotein values for the first 8 hour sample have high correlation with the entire 24 hour sample for patients with mild (p<0.001,r=0.87),severe disease (p<0. 001, r=0.9). In cases with no proteinurea moderate correlation was found (P<0.001, r=0.59).ConclusionThe 8-hour sample correlates with the 24-hour sample for patients with no proteinuria (p<0.001), mild proteinuria (p<0.001) and severe proteinuria (p<0.001).