A survey of obesity and abnormal glucose tolerance in first degree relatives of women with polycystic ovarian syndrome referred to gynaecology clinics of Shiraz university of medical sciences

Polycystic ovarian (pco) syndrome is one of the most prevalent(4-8%) endocrine glands disorders among premenopause women. Polycystic ovary syndrome as a form of functional ovarian hyperandrogenemia may has characteristics such as; choronic anovulation, infertility, abnormal menstruation and android obesity. This diseas has genetic aspect and in different studies similar abnormalities have been seen in their first degree relatives. This research is a case-control study carried out on 107 individuals as case group and 107 individuals as control group selected by simple random sampling in 2009. After recognition patients with PCO syndrome, their first degree relatives (Father,mother,sister and brother) have been interviewed. BMI and WHR indices of the both blood samples were taken to study their serum glucose tolerance. Case group, from view point of obesity (BMI≥30) and centeral obesity, ITG level and diabetes regarding WHO standards was higher than similar individuals in control group,but this difference was not statistically significant. The mean of fasting blood sugar in fathers, mothers, brothers and sisters of cas group was significantly higher (p=0.001). Regarding Chi-square test there was no significant relation between obesity diabetes in the both groups., (BMI≥30kg/m2), centeral obesity and lack of impaired glucose tolerance and type2 diabetes in the both groups. The first degree relatives of the women suffering from polycystic ovarian syndrome are exposed to abnormal glucose tolerance and android obesity.