Serum level of Homocysteine, folic acid and vitamin B12 in ‎hemodialysis patients referring to hemodialysis unit of Jahrom ‎hospital

Homocysteine is an aminoacid yielded from methionin to cysteine metabolism. ‎Increasing more than normal levels can increase the risk of cardiovascular diseases. Some reasons ‎such as uremia, genetic factors, dialysis related factors and vitamin B group deficiency lead to ‎increases the plasma level of homocysteine in dialysis patients. This study was done to evaluate ‎Plasma vitamin B12, Folic acid and homocysteine levels in Jahrom hemodialysis patients.‎

This cross sectional study was carried out on a total of 43 patients, who were on ‎hemodialysis and 43 age and sex matched healthy individuals without any underlying renal disease ‎as a control group, Dec 2008- Sep 2009. The serum level of homocysteine was measured by an ‎ELISA method and the serum levels of vitamin B12 and Folic acid were measured by an RIA method.‎ Rults: There were significant differences between Mean serum levels of homocysteine 22.709±5.765 ‎‎µmol/L vs 16.518±5.425 µmol/L, vitamin B12 513.814±15.378 ng/ml vs 22.976±7.462 ng/ml and Folic ‎acid 5366.814±1734.752 pg/ml vs 868.907±251.484 pg/ml in the patients group and in the control ‎group (P