A Comparative study of effect of myrtus vaginal cream and clotrimazol vaginal cream in the treatment of vaginal candidiasis

Vaginal candidasis is the most prevalent gynaecologic problem and the reason for 10 million consultations per year. Topical drugs, including Azole are commonly used for the treatment of vaginal candidiasis. In som cases, however these drugs cause adverse effects, or they are associated with a high rate of relapse. Many reports recently have been presented about antifungal and antimicrobial effects of myrtle extract.The purpose of the present study was to compare the effect of myrtus vaginal cream with clotrimazol vaginal cream in the treatment of vaginal candidiasis. The study was a double-blind randomized clinical trial which has been accomplished on 80 non pregnant women. Gynaecological and microbilogical evaluations were carried out before and after the treatment. 7 day usage of myrtus vaginal cream for study group and clotrimazol vaginal cream for control group were prescribed. Data were obtained by interview and observation methods and were analyzed by Chi – square, Student T-test and Mann Witney, Mc Nemar,s and, Wilcaxon tests. Our data showed a statistically significant difference in vaginal itching and vaginal discharge after treatment between two groups. Percentage of successful response to itching and vaginal discharge in users of myrtus vaginal cream was more than users of clotrimazol vaginal cream. (p<0/002). The first positive culture results between myrtus and cloteimazol group (7.5%vs 17.5%) and secound positive culture results (15% vs 25.6%) were similar within the 2 groups, with no significant statistical difference. Both the myrtus and clotrimazol creams significantly reduced all signs and symptoms of vaginal candidiasis, however use of myrtus vaginal cram was found to be more effective in the treatment of the most common symptoms of vaginal candidiasis. therefore, use of myrtus vaginal cream is suggested for treatment of vaginal candidasis.