The effect of guar gum powder (Cyamopsis tetragonolobus) on plasma glucose and lipids in diabetic rat

Diabetes mellitus is an important risk factor for several diseases such as cardiovascular diseases, stroke and renal failure. Guar gum as a soluble dietary fiber can impair glucose uptake. Therefore, we investigated the effect of guar gum powder on glucose level and lipids of plasma in diabetic rats.
Material and Male Wistar rats with weighting range of 245±35 gr were made diabetic with an intraperitoneal injection of streptozotocin(85mg/kg). The animals were divided into four groups including diabetic group who received %5 of guar gum in their diet, diabetic group who received 2mg/kg glibenclamide, diabetic control group and normal control group. Experiment period continued 28 days. Blood sampling from rats was performed at 0th, 7th, 14th, and 28th days after inducing diabetes. And glucose, triglyceride, LDL-C and HDL-C of serum were evaluated at the aforementioned time intervals. Our data showed that glucose and HDL-C level of serum of rats that received a diet including 5% guar gum did not change significantly in comparison with diabetic control group during 28 days (p>0.05).But cholesterol, LDL-C (p