Improved tabletting properties of ibuprofen using evaporative precipitation with gelatin
Author(s):
Abstract:
Objectives
Ibuprofen is a problematic drug in tableting due to its high cohaesivity and viscoelastic properties. In this study coprecipitation of ibuprofen with varying concentration of gelatin to optimize properties of Ibuprofen was carried out. Methods
Optical microscopy and differential scanning calorimetry (DSC) were used to investigate the physical characteristics of the co-precipitates. The dissolution behavior, flowability and compaction properties of various batches were also studied. Results
Co-presipitation of drug with gelatin led to a change in habit from needle to plate shape crystals. The co-presipitates showed improved flow properties, while no change in dissolution rate of them was observed compared with ibuprofen alone. All of the obtained co presipitates exhibited significantly improved tableting behavior compared with drug crystals alone. Due to the fact that the polymer covering the drug particles increases and changes the nature of the surface area available for interparticulate bonds between particles. DSC experiment showed that drug particles, in co-presipitates samples, did not undergo structural modifications.Conclusion
The study highlights the influence of polymeric additives on crystallization process leading to modified performance.Keywords:
Ibuprofen , Gelatin , Co , precipitation , Crystallization
Language:
Persian
Published:
Pharmaceutical Sciences, Volume:17 Issue: 1, 2011
Page:
19
magiran.com/p878259
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!