study of the role of common bacterial etiology in neonatal sepsis in Urumiah Shahid

Aim and Background. The aim of this study was to assess the most common bacterial etiology in neonatal sepsis which has been carried out during the years 2005-2006 at Urumiah Shahid Arefian Hospital. Materials and Methods. In this cross-sectional study، after collecting blood samples from 402 newborns who were suspicious to sepsis and performing microbial culture and bacterial isolation، disk diffusion antibiotic susceptibility test was done according to the CLSI guidelines. Results. Overall، 36 positive cultures were acquired. The prevalence of sepsis were higher in the male infants (61/1%) than female (38/9%) Conclusion. With respect to increasing prevalence of neonatal sepsis with coagulase negative staphylococci، in this study and similar studies، with appropriate antibiotical therapy according to antibiogram results، with considering hygienic principles in hospitals and prenatal care، we may able to decrease mortality and morbidity of neonatal sepsis. (P=0) Among these، 63/9% were born with normal vaginal delivery and 36/1% were c-section delivered babies (P=0/093). The mean weight of 36 neonates was 2117837 gr and there was a significant relationship between low birth weight and prevalence of sepsis (p=0). The most common microorganisms of neonatal sepsis were coagulase negative staphylococci (50%) and klebsiella pneumoniea (19/4%). The gram-positive isolates showed the highest sensitivity and resistance rates to vancomycin and to Ampicillin، respectively. The highest sensitivity and resistance rates for the gram negatives were towards ciprofloxacin and cefotaxime، respectively. Low birth weight and prematurity were the major risk factors of sepsis.