Comparing of efficacy of intraoperative administration of three doses of Ringer solution on PONV prevention in patients undergoing Tympanomastoidectomy surgery

PONV is a common complication after ENT surgeries (37-42%). Common drugs used for PONV prevention have different side effects. In recent studies preoperative fluid therapy has known as an effective method for PONV prevention. In this double blind RCT 97 patients undergoing Tympanomastoidectomy surgery have assessed for incidence and severity of PONV and postoperative pain (POP) in 3 groups. Patients received 3 doses of ringer solution during anesthesia: 4cc/kg (G4, n=30), 10cc/kg (G10, n=33), 20cc/kg (G20, n=34) Patients in 3 groups was identical in mean age, mean weight, sex, anesthesia duration and anesthetic management. Incidence and severity of nausea and POP in G4 was significantly greater comparing with two other groups in a dose dependent manner. Only 3 cases had vomiting in G4 and not in two groups. Sore throat and dizziness in G4 were more than other groups but were not statistically significant. So because of more efficacy of 20cc/kg ringer solution to PONV and POP prevention than lower doses in patients undergoing Tympanomastoidectomy surgery and cost effectiveness and safety of this method, we propose this as a routine method in PONV and POP prevention in ASAΙ patients in moderate lasting surgeries (≈2һ)