Molecular Mechanism of Peroxisome Proliferator Activated Receptors during Inflammation

Inflammation is the normal response of the body to injuries to remove dead cell debris and infections at injury sites and repair the tissue. However, excessive inflammation is harmful to the body because of its positive feedback and disruption of normal cells. Thus, recruitment of the regulatory mechanisms for modulating the inflammation is crucial for the body. Peroxisome Proliferator-Activated Receptors (PPARs) are ligand-activated transcription factors and members of the nuclear receptor super family. Among these superfamily members, PPARγ ia involved in the regulation of numerous cellular processes such as inflammation. Several activators of PPARγ have been known to exert possible roles in immune function through mechanisms such as transactivation of genes that suppress the inflammation, trans-repression of inflammatory genes, interaction with other receptors that lead to effective suppression of the inflammatory agents. Here in this review article, we describe the molecular events which are triggered by these molecules in elaboration of inflammation process.