Evaluation of oral clonidine premedication on hemodynamic parameters during laparoscopic cholecystectomy

During the laparoscopic surgery, intra abdominal pressure (IAP) will be elevated then the hemodynamic changes could be occurred. This study was conducted to determine whether the pre-treatment with oral clonidine can attenuate the laparoscopic hemodynamic changes. Forty patients whom were candidate for elective surgery under general anesthesia, were randomly divided into two equally groups. One group received preoperative oral clonidine peel and the second group received preoperative placebo. Then the collected data was analyzed with Chi – square and T-Student test. Also the repeated measurement analysis of variance tests was performed by by SPSS software ver. 13.The results were reported bymean ± SD. P lower than 0.05 was considered as statistically significant level. Two groups were similar about the demographic parameters including age, weigh and sex (p>0.05). In the clonidine group hemodynamic changes such as SBP, DBP, HR and ECG abnormalities were lower during anesthesia (P<0.05). Pre-medication with oral clonidine can be attenuated the hemodynamic changes during the laparoscopic surgery such as SBP, DBP and HR. Also decrease in the ECG abnormalities during anesthesia were reported.