A Comparison of Cephalexin with Fosfomycin Trometanol (monurol) in the treatment of pregnant women with lower urinary tract

Because of the relation between bacteriuria in pregnancy and low birth weight and immaturity, a proper and suitable treatment is important. Fosfomycin Treometamol is one of the most safe drugs in pregnancy. This study was designed to compare it with Cephalexin. In this randomized clinical trial, 166 pregnant women with. positive urine culture (cfu >105) were randomized into two groups to receive Cephalexin and Fosfomycin. Urine cultures were repeated one week and one month after treatment. The most bacteria in Cephalexin groups were E.coli (87.8%), Streptococcus (7.3%)< Proteus (2.4%) and Klebsiella (2.4%), and in the later group they were E.coli (84.5%), Streptococcus (9.5%)< Proteus (4.8%) and Klebsiella (1.2%) with no significant difference (p=0.737). After one week, success rate in Cephalexin group was 92.7% and for Fosfomycin was 91.7% (p=1). The odds ratio was 15.15 and relative risk was 1.01. All the cultures were negative after one month. 2 in the Cephalexin group and 3 in the Fosfomycin group had diarrhea (p=0.68). Considering the equality between Cephalexin and Fosfomycin, Fosfomycin can be used to treat uncomplicated bacteriuria in pregnancy.