|تاریخ چاپ: 1399/06/29|
|Evaluation of Nephroprotective Effects of Hydroalcoholic Extract of Cyperus scariosus Linn. in Gentamicin-induced Acute Kidney Injury in Wistar Albino Rats|
|Author(s):||Khushboo K. Gajjar، Amol S. Aiwale، Ashish P. Anovadiya، Ashvin V. Mevada، Seema N. Baxi، C. B. Tripathi *|
BackgroundGentamicin is a commonly used antibiotic for the treatment of Gram-negative infections, but nephrotoxicity limits its use. Cyperus scariosus Linn. (CS) has been found to have antioxidant properties in vitro.
ObjectivesThe aim of this study was to evaluate the nephroprotective effects of CS in gentamicin-induced acute kidney injury (AKI).
MethodsThe animals were divided into nine groups. AKI was produced with a 100 mg/kg intraperitoneal (i.p.) injection of gentamicin for 7 days. Next, α-lipoic acid 100 mg/kg i.p. served as the active control, while the test drug (CS) was given in two doses (150 mg/kg and 250 mg/kg orally) for 10 days. Distilled water, 1 ml/day orally for 7 days, served as the vehicle control. The protective and curative effects, respectively, were assessed by the administration of CS before and after the induction of AKI. The effects of CS on AKI were assessed by serological and histopathological parameters.
ResultsSerum creatinine was significantly increased (P
ConclusionsIn our study, hydroalcoholic extract of Cyperus scariosus Linn. offered nephroprotection in the form of AKI prevention and for the treatment of established AKI.
|Keywords:||Gentamicin، Acute Kidney Injury، Oxidative Stress، Nephroprotective، Cyperus scariosus Linn|
|Published:||Jundishapur Journal of Natural Pharmaceutical Products (JJNPP), Volume:11 Issue: 3, 2016|
|Full text:||PDF is available on the website.|