|تاریخ چاپ: 1399/09/08|
|The Effects of Probiotic Supplementation on Gene Expression Related to Inflammation, Insulin and Lipid in Patients with Parkinson's Disease: A Randomized, Double-blind, PlaceboControlled Trial|
|Author(s):||Shokoofeh Borzabadi، Shahrbanoo Oryan*، Akram Eidi، Esmat Aghadavod، Reza Daneshvar Kakhaki، Omid Reza Tamtaji، Mohsen Taghizadeh، Zatollah Asemi|
BackgroundThis study was conducted to evaluate the effects of probiotic supplementation on gene expression related to inflammation, insulin and lipid in patients with Parkinsons disease (PD).
MethodsThis randomized, double-blind, placebo-controlled clinical trial was conducted in 50 patients with PD as a pilot study. Participants were randomly allocated into two groups to take either 8×109 CFU/day probiotic supplements or placebo (n = 25 each group, one capsule daily) for 12 weeks. Gene expression related to inflammation, insulin, and lipid was quantified in peripheral blood mononuclear cells (PBMC) of PD patients, with RT-PCR method.
ResultsAfter the 12-week intervention, compared with the placebo, probiotic intake downregulated gene expression of interleukin-1 (IL-1) (P = 0.03), IL-8 (P
ConclusionOverall, probiotics supplementation for 12 weeks in PD patients significantly improved gene expression of IL-1, IL-8, TNF-α, TGF-β and PPAR-γ, but did not affect gene expression of VEGF and LDLR, and biomarkers of inflammation and oxidative stress.
|Keywords:||Inflammation، insulin metabolism، Parkinson's disease، probiotics supplementation|
|Article Type:||Research/Original Article|
|Published:||Archives of Iranian Medicine, Volume:21 Issue: 7, 2018|
|Full text:||PDF is available on the website.|