|تاریخ چاپ: 1399/05/14|
|Nephroprotection and chemotherapy sensitivity impact ofmetformin during cisplatin therapy; an updated review|
|Author(s):||Mohsen Akhavan Sepahi*، Sarvenaz Mehrabi، Rohollah Valizadeh، Steven James Kellner، Azin Mirzazadeh، Semko Ebrahimi|
Chemotherapy has been accepted as the most common choice for cancer treatment. However, chemotherapy-induced toxicity and chemotherapy resistance are the two challenging barriers to the treatment. Metformin is a safe, inexpensive, and the first line drug to treat type II diabetes. It has also a significant anti-tumor effect with a selective cytotoxic efficacy on cancer stem cells. It also has renoprotective efficacy. The current study contributes to incorporating metformin to chemotherapeutic agents to develop treatment efficiency and reduce the chemotherapy-induced side-effects (such as toxicity and resistance) and also to benefit the nephroprotective impact of this drug.
|Keywords:||Chemotherapy، Metformin، Cisplatin، Nephroprotection، Reactive oxygen species، Kidneys، Tumor، Nuclear factor (NF)-κB، Cisplatin cytotoxicity|
|Article Type:||Review Article|
|Published:||Journal of nephropathology, Volume:8 Issue: 4, 2019|
|Full text:||PDF is available on the website.|