|تاریخ چاپ: 1399/08/04|
|Repeated Transcranial Direct Current Stimulation (tDCS) on Methamphetamine Craving: A Randomized, Sham-controlled Study|
|Author(s):||Mahsa Rohani Anaraki، Behrouz Dolatshahi*، Masoud Nosratabadi، Mohsen Nouri Yalghouzaghaji، Sajede Rezaei Mashhadi|
The modulation of the dorsolateral prefrontal cortex (DLPFC) activity enhanced the prospects of substance use disorders rehabilitation, using non-invasive brain stimulation, such as transcranial Direct Current Stimulation (tDCS).
We carried out a randomized sham-controlled clinical trial to assess the effect of repeated tDCS at DLPFC on drug craving in 30 abstinent male methamphetamine users. The participants underwent 5 sessions of 20 minutes bilateral real or sham 2 mA tDCS (anode right/ cathode left) of DLPFC. The Desire for Drug Questionnaire (DDQ) was used for assessing instant craving. The cue-induced craving was rated on a Visual Analog Scale (VAS) after the verbal induction of craving.
The findings of this study indicated that cue-induced craving reduced significantly in tDCS related to sham (P<0.05), but tDCS did not significantly alter instant craving.
The results indicated that repeated bilateral tDCS over DLPFC was not effective in reducing self-report instant craving, but reduced self-reported craving in the craving induction condition.
|Keywords:||Transcranial Direct Current Stimulation، Methamphetamine craving، Dorsolateral prefrontal cortex|
|Article Type:||Research/Original Article|
|Published:||Iranian Rehabilitation Journal, Volume:17 Issue: 42, 2020|
|Full text:||PDF is available on the website.|