The present study aimed to determine the effectiveness of acceptance and commitment-based therapy on emotional regulation and psychological well-being of women with vitiligo skin disease. The research method was semi-experimental with a pre-test-post-test design and a control group. The statistical population of this research included all patients suffering from vitiligo (spots and psii) referred to specialized skin and beauty clinics in Tehran in 2023, of which 30 people were selected using the purposeful sampling method and randomly assigned to two groups (15 people were placed in the experimental group and 15 people in the control group). The measurement tools included the Garnevsky and Kriage Emotion Regulation Questionnaire-short version (CERQ, 2006) and the Riff Psychological Well-Being Questionnaire-short version (RSPWB, 2002). The experimental group underwent group therapy based on acceptance and commitment during 8 sessions of 90 minutes twice a week, and the control group did not receive any therapeutic intervention. Multivariate analysis of the covariance test was used for analysis. The results of covariance analysis showed that by controlling the pre-test effect, there is a significant difference between the average emotional regulation and psychological well-being in the two experimental and control groups (P<0.001). The findings of this research showed that group therapy based on acceptance and commitment was effective in reducing negative emotion regulation and increasing positive emotion regulation and the psychological well-being of women with vitiligo.