In order to study the beneficial role of aerobic activities and consumption of saffron which has various biological properties, the adaptability of serum irisin, lipid profiles and insulin resistance to an aerobic training and consumption of saffron sprouts as well as its sustainability in type 2 diabetic obese women was closely examined.
Forty-eight type 2 diabetic obese women were randomly divided into four equal groups (saffron training, training placebo, saffron, placebo). The saffron group training and training placebo groups did aerobic training with an intensity of 60-75% of maximal heart rate for 8 weeks (three sessions per week). A daily dose of 400 mg of saffron sprout powder (once a day) was used for two months. The placebo contained 400 mg of wheat flour. Then, the variables of irisin, lipid profiles, and HOMA-IR were investigated.
The results of this study showed that there were significant differences between training saffron group and training placebo, training saffron and saffron, training saffron and placebo, training placebo and placebo, and saffron and placebo (P Eight weeks of aerobic training and saffron consumption have a significant effect on the indices related to type 2 diabetes. It needs to be mentioned that the consumption of saffron along with aerobic exercise has more effects on controlling these indices.

The purpose of this study was comparison of the effect of a therapeutic exercise program and oral administration of saffron on the levels of IL-6, TNF-a and glycemic control in type 2 diabetic women
48 type 2 diabetic obese women were randomly divided into four equal groups (saffron training, training placebo, saffron, placebo). The saffron group training and training placebo groups performed aerobic training with intensity of 60-75% of maximal heart rate for 8 weeks (three sessions per week). Daily dose of 400 mg of Saffron sprout powder (once a day) was used for two months. The placebo contained 400 mg of wheat flour. The following IL-6, TNF-a, Blood glucose and HbA1c variables; lipid profiles and HOMA-IR were tested. The Shapiro-Wilk test, variance analysis with repeated measures, Bonferron's post hoc test, and one way analysis of variance with LSD post-test.
In the post-test phase, the pre-test the variables IL-6 and TNF-α, blood glucose and HbA1c in intervention groups decreased significantly, and also in the post-test between group, saffron training with training placebo, saffron training with saffron, saffron training with placebo and saffron with placebo there was a significant difference (p It can be possible aerobic exercise and saffron consumption have a protective effect against the increased levels of blood glucose and HbA1c. It is possible that the reduction of blood glucose, IL-6 and TNF-a in saffron recipients is due to the presence of saffron metabolites, especially flavonoids (crostein and crocin) and increased antioxidant defense system through saffron.

nausea and vomiting is one the most common problem during pregnancy. There are several reports about treating effect of acupressure for nausea and vomiting. Our propose was to investigate of p6 acupressure in reducing and relieving of symptoms of nausea and vomiting during pregnancy. A single blind clinical trial has been conducted in order to examine the effect of P6 acupressure on nausea and vomiting of pregnancy in women referring to health center of Ardebil at 2005. 75 women complained of nausea and vomiting after being matched on the basis of the intensity of nausea and vomiting and pregnancy period were invited to participate in the study. Subjects were divided into three groups of treatment, placebo, and control (25 persons in each group), accidentally. Women in treatment group use acupressure wristbands with pressure to P6 acu-point, in placebo group use acupressure wristbands without pressure to P6 and control with no intervention. The symptoms were evaluated for 6 days and twice daily using a questionnaire inspired by Rhodes Inventory of Nausea and Vomiting. In the first 3 days all there groups equally filled the questionnaire and in the second 3days the treatment and placebo groups filled there out. Data of frequency, duration, and severity of nausea and frequency of vomiting were analyzed by Analysis of variance and Wilcoxon means were compared with Tukey and Kruskal-wallis tests. Analysis revealed that the participants in three groups didnt have significant differences in regard to age (treatment 24.3±3.9, placebo 24.9±4.3, control 25.4±3.3 year), gestational age (treatment 12.4±2.8, placebo 12.9±3.1, control 12.4±2.8 week) number of parity (treatment 1.7, placebo 1.6, control 1.4 times) education, job, number of pregnancy. The mean score of nausea severity decreased from 25.1±18.6 to 12.0±11.0 in treatment group, from 22.8±14.6 to 16.1±12.31 in placebo group but increased from 16.3 ±7.48to 17.5±8.92 in control group. The mean of vomiting frequency also decreased from 3.1±3.33 to 1.5±1.66 and from 3.1±4.30 to 1.9±3.68 in treatment and placebo group, respectively; but its value changed from 1.2±2.2 to 1.4±1.4 in control group. Differences between pre-treatment and treatment period of nausea and vomiting symptoms was not significant in treatment group than placebo groups (p<0.043) and it was more in the placebo compared to control group (p<0.009). Comparing of means in treatment and placebo groups showed significant difference in nausea frequency and severity but not significant differences in duration of nausea and frequency of vomiting. P6 acupressure wristband is effective in the treatment compared to control and placebo for reduction of severity, duration and frequency of nausea and frequency of vomiting. The wristband without pressure to P6 acu-point also is affected in reducing nausea and vomiting symptoms but its effect is lower than P6 wristband.

Micronutrient deficiencies of zinc and selenium can lead to thyroid dysfunction. The objective of this study was to determine the effects of zinc and selenium supplementation on thyroid function of over-weight or obese hypothyroid female patients. This was a double-blind randomized clinical trial study. Sixty-eight over-weight or obese hypothyroid female patients randomly allocated in one of the four supplementation groups receiving zinc+selenium (zinc gluconate contains 30 mg zinc and selenium yeast contains 200 μg selenium)، zinc+placebo، selenium+placebo or placebo+placebo for 12 weeks. At baseline and at the end of the study، general information، anthropometric factors، dietary intake and biochemical parameters were measured. Physical activity questionnaire was completed. The N4 and SPSS software version 16 were performed for nutritional and statistical analysis. After the intervention period، no significant changes were found in serum zinc and selenium levels. Significant increase was observed in serum FT3 levels in the zinc+selenium group (p<0. 05) and zinc+placebo (p<0. 01) compared to baseline. This effect was significant in the zinc+placebo group compared to those in the selenium+placebo or placebo+placebo groups (p<0. 05). Serum FT4 increased and TSH decreased significantly in the zinc+selenium group (p <0. 05). TT3 and TT4 had a significant reduction in the selenium+placebo group (p <0. 05). No significant changes were found for TT3، FT4، TT4 or TSH between groups. This study showed some evidence of supplementation effects of zinc alone or in combination with selenium on thyroid function of over-weight or obese hypothyroid female patients.

Electroconvulsive therapy (ECT) may cause severe hemodynamic changes which carry the potential risks. We designed a study to evaluate the effects of Dexmedetomidine on hemodynamics in ECT.
Material and This prospective randomized double-blind study was designed to evaluate the effect of dexmedetomidine on the acute hyperdynamic responses, duration of seizure activity and recovery times in patients undergoing ECT. Sixty three patients divided in to four groups; for induction of anesthesia, one group received etomidate-dexmedetomidine, the other group etomidate-placebo, another group propofol-dexmedetomidine and the last group propofol-placebo. Heart rate and blood pressure were measured just before ECT and at the 1PstP, 3PrdP, 5PthP and 10PthP minute afterward. Duration of convulsion and recovery time were also recorded.
systolic blood pressure at 3rd minute and 10th minute was lower in propofol-dex group comparing propofol-placebo and etomidate-dex comparing etomidate-placebo, respectively which was statistically meaningful. Recovery time was longer in etomidate-dex comparing etomidate-placebo, which was statistically meaningful.
dexmedetomidine prescription could prevent blood pressure rise in ECT

Obesity is a very important cause of many chronic diseases. One of the ways to control weight and obesity is to have regular physical activity and the use some medicinal herbs. The purpose of this study was to investigate the effects of ginger supplementation per se and in combination with high intensity interval training (HIIT) on the anthropometric indices and serum levels of irisin in obese men.

Sixty-four obese men, aged 20 to 35 years were randomly assigned into 4 groups for 10 weeks: Group 1) ginger supplement, Group 2) ginger supplement+training, Group 3) training+placebo, and Group 4) placebo. Individuals in groups 1 and 2 (ginger and ginger+training), received three ginger capsules (1 g daily) and subjects in groups 3 and 4 (training group+placebo) and placebo groups received the same amount of placebo capsules with each meal. Participants in the ginger+training and training+placebo groups participated in a HIIT protocol for 10 weeks.  Data on anthropometric measurements, serum irisin levels and dietary intakes were collected at the beginning and at the end of the study.

The ginger intervention per se, reduced body fat percentage within groups (P=0.001). In ginger+training and training+placebo groups significant decreases were observed in anthropometric indices including weight, body fat percentage, waist circumference, waist-to-height ratio, compared to the placebo group (P<0.05). No significant difference was observed in serum levels of irisin in any of the studied groups at the end of interventions (P>0.05).

HIIT exercises alone and in combination with ginger were effective in improving anthropometric indices.

The aim of present research was the effect of short-term use of edible solution of jujube one week before a single session of circuit resistance exercise on neutrophil apoptosis of male students of physical education. 14 young male volunteer students were divided into two groups of placebo (n=7, aged 24.50±2.50, height 171.17±1.70, and weight 67.51±4.92) and jujube solution (n=7, aged 25.25±1.31, height 179.75±3.63, weight 74.07±5.78) at random, performing one circuit resistance exercise (9 moves/stops, 30 seconds for each exercise, 3 nonstop sets with a 3-minute active recession between sets, 10-14 repetitions, and an intensity of 70% maximum repetition). Subjects received placebo and jujube solutions (0.5 g/kgbody weight in 2.5cc of distilled water as long as 7 days) at certain times and double-blind. Blood samples were collected 30 minutes before, immediately, and 2 hours after the exercise for separation and counting the number of neutrophils, and neutrophil apoptosis was determined through AnexinV-FITC kit and flow cytometric method. The results indicated the significant response of initial apoptosis neutrophils to one course of activity by jujube group. However, different responses were observed between two groups of placebo and jujube during the recession after training. Unlike placebo group, the response was significantly lower with a greater decrease after training in jujube group. However, necrosis/delayed apoptosis neutrophils significantly increased in placebo group after 2 hours, while this change was not observed in jujube group. At the end of a 2-hour recession, delayed apoptosis neutrophils significantly decreased in both placebo and jujube groups. The present findings indicate that one-session resistance activity is not very effective after pretreatment with jujube solution during one week. Perhaps this useful effect of jujube can be explained by existing glucose compounds and amino acids which could provide neutrophils with proper nutrition source in comparison with placebo. It is possible that jujube resulted in improvement of neutrophil’s antioxidant capacity, because it has proper antioxidant materials. Therefore, it might be stated that loading with edible jujube solution can be effective in inhibiting apoptosis at least for one week.