مجله دانشگاه علوم پزشکی قم
سال نهم شماره 10 (پیاپی 45، دی 1394)

Tetracyclines are antibiotics that are widely used. Tetracycline, easily passes the blood-brain barrier and protects the nervous system due to its specific chemical structure. Vitamin E is one of the fat-soluble vitamins. This vitamin helps prevent the progression of Alzheimer's disease. The purpose of the present study is to investigate the effects of tetracycline and vitamin E on spatial memory, learning, and depression. In this experimental study, 21 male Wistar rats were randomly divided into 3 groups of 7 each. The effect of tetracycline and vitamin E on memory, learning, and depression was investigated using 8-arm radial maze and elevated plus maze. Data were analyzed by one-way ANOVA and Tukey's statistical tests. Statistical significance level was considered p<0.05. After 21 days of treatment, it was shown that tetracycline antibiotic has a significant effect on memory. Also Vitamin E significantly reduced depression and its protective effect decreased the adverse effect of tetracycline. In the treatment group, vitamin E along with tetracycline had a significant effect on memory loss. The results of the present study indicated that use of vitamin E can reduce depression by its antioxidant and protective effects. Tetracycline also significantly increases memory. Therefore, according to the results, it is suggested that tetracycline be used along with vitamin E to reduce negative effects of the drug.

Cancer is one the major causes of mortality in today's world, and is considered as one of the most important health problems in societies. Most of the proposed methods for classifying cancer by gene expression data act as a black box and lack biological interpretability. The aim of this study was to introduce an optimal approach with the interpretability of gene expression. In this study, the combined filter-wrapper feature selection method was used to select a subset of cancer-causing genes, which this method significantly reduced the number of samples in comparison with the number of genes. Also, in this study, data discretization, generation and reduction of rules, and evaluation of results were performed by combining the fuzzy clustering methods, rough sets theory, and K-set validation. Accordingly, a new method with biological interpretability and meaning extraction from gene expression data was introduced, which is called “Fuzzy Rough Set Classification”. Using filter-wrapper feature selection method for lymphoma microarray, 6 genes were selected from 4029 genes. In fuzzy roughest classifier method, two rules were generated in order to develop a classifier model with interpretability of gene expression. In this method, using ranking functions, the most important fuzzy rules were selected, which in addition to generation of an efficient model, the interpretability of gene expression data is made possible. Another prominent feature of this method was successful solution of the problem of disproportion between the number of samples and genes in microarrays by the proposed filter-wrapper feature selection method.

Type, intensity, and duration of exercise determines the effect of exercise on the immune system. This study aimed to determine the effect of different exercise intensities on cytokine response pattern in male football players In this quasi-experimental study, 11 male football players of Jahrom University (mean height, 1.70±0.04m; weight, 64.42±6.44kg; age, 21.90±0.87 yr; body mass Index, 22.05±1.68kg/m2) with at least 6 months of activity, were studied. In the first week, the participants ran one session at 65% of maximum heart rate and in the second week, one session at 80% of maximum heart rate for 30 minutes at running track. Blood samples were taken before and immediately after each training session. Data were analysed using dependent t-test and repeated measures ANOVA. The significance level was considered p<0.05. Exercise at 65% of maximum heart rate had no significant effect on IFN-γ (p=0.60), IL-4 (p=0.14), and IFN-γ/IL-4 ratio (p=0.22). A session of exercise with 80% of maximum heart rate, had no significant effect on IL-4 (p=0.57) and IFN-γ/IL-4 ratio (p=0.38), whereas the level of IFN-γ significantly decreased (p=0.01). Based on the results of this study, the immune response changed with the intensity of the exercise, and exercise at 80% of maximum heart rate had a significant effect on the IFN-γ response compared to the exercise at 65% of maximum heart rate.

Febrile convulsion (FC) is the most common seizure disorder in children and is seen in 2-5% of children under 5 years of age. This study was performed to determine the relationship between febrile convulsion and iron deficiency anemia in children. In this case-control study, 65 hospitalized children with febrile convulsion in Qom Hazrat Fatemeh Masomeh Educational and Treatment Center, were assigned to patient group and 65 children with fever without convulsion were placed in control group. After resolution of fever, 2ml blood samples were taken from all the children and blood parameters, hemoglobin, and hematocrit were measured. MCV, MCH, and MCHC tests were performed to rule out thalassemia. Data were analyzed by chi-square and t-test at the significance level of less than 0.05. The rate of iron deficiency anemia was significantly lower in febrile convulsion group compared to febrile without convulsion group, so that 33.8% of the children of the febrile convulsion group had anemia. This rate was 53.8% in the control group, which the difference was statistically significant. The results of this study indicated that iron deficiency anemia was less frequent in the febrile convulsion cases, as compared to the control group, and iron deficiency anemia could have a protective effect against the incidence of febrile convulsion, therefore, more studies should be done to confirm it.