فهرست مطالب

  • Volume:17 Issue: 2, 2016
  • تاریخ انتشار: 1395/01/09
  • تعداد عناوین: 5
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  • Mohammad Aghaali*, Seyed Fakhreddin Hejazi, Leili Iranirad, Akram Heidari Page 1
    Background
    Uric acid, a product of purine degradation, is a risk factor for cardiovascular disease. Studies have demonstrated a relationship between uric acid and increased inflammatory and oxidative stress in the general population. Recent studies also confirmed the role of inflammatory factors and oxidative stress in atrial fibrillation (AF)..
    Objectives
    The purpose of this study was to investigate the relationship between serum uric acid levels and the risk of AF..
    Patients and
    Methods
    This case-control study consisted of 32 patients with AF and 32 healthy controls. Both groups were matched by age, sex, and underlying disease. The diagnosis of AF was based on an electrocardiogram and confirmed by a cardiologist. Patients with heart failure, coronary artery disease, recent infection, renal failure, thyroid disorders and malignancy or who were treated with drugs affecting serum uric acid were excluded. The uric acid levels in both groups were measured using an enzymatic method. The mean serum uric acid of the two groups was compared with a t-test and SPSS software..
    Results
    The female to male ratio in the two groups was 1.28. The mean age of the patients in the AF group and control group was 69.12 ± 11.8 and 67.75 ± 14.8, respectively. There were no significant differences in the age and sex of the two groups. The mean serum uric acid in the AF group and control group was significantly different (5.79 ± 1.19 mg/dL and 4.81 ± 1.26 mg/dL, respectively; P = 0.002)..
    Conclusions
    The results suggest that serum uric acid can be considered a risk factor for AF. Further studies are recommended to investigate the role of uric acid reduction in the prevention and treatment of AF..
    Keywords: Atrial Fibrillation, Adult, Uric Acid
  • Maryam Paknahad, Shoaleh Shahidi, Seyed Mohammad Javad Mortazavi, Ghazal Mortazavi, Mahdi Saeedi Moghadam, Ali Dehghani Nazhvani* Page 2
    Background
    Previous studies have reported an increase in the mercury release from dental amalgam restorations, following exposure to electromagnetic fields generated by sources such as mobile phones and magnetic resonance imaging (MRI). It has also been shown that MRI increases microleakage of amalgam restorations. In this study, Helmholtz coils are used for generating pulsed electromagnetic fields (PEMF)..
    Objectives
    The purpose of this study was to evaluate the effect of PEMFs on microleakage of amalgam restorations, using a pair of Helmholtz coils..
    Patients and
    Methods
    Standardized class V cavities were prepared on the facial surfaces of 46 non-carious extracted human premolars. Then, the samples were randomly divided into experimental and control groups, each containing 23 teeth. The experimental group was exposed to the uniform magnetic fields generated by a pair helmholtz coils. The magnetic field strength at the central point of the two coils was 0.1 mT. All specimens were placed in 2% basic fuchsin solution. Then the teeth were sectioned, examined under a stereomicroscope, and scored for microleakage according to the degree of dye penetration..
    Results
    There was no significant difference between the two groups regarding the microleakage score..
    Conclusions
    The results of the present study suggest that PEMF exposure does not have adverse effects on microleakage of amalgam restorations..
    Keywords: Pulsed Electromagnetic Fields, Amalgam, Microleakage, Helmholtz Coils
  • Samaneh Khazaei Asl, Ali Shahraki*, Zahra Zakeri Page 3
    Background
    Dermatomyositis (DM) and polymyositis (PM) are common forms of idiopathic inflammatory myopathy which are characterized by muscle inflammation with an unknown cause. Immune cells infiltrate myofibrils and endomysial capillaries, which leads to damage of muscle fibers through the production of humoral factors and different cytokines..
    Objectives
    Increased IL-18 and IL-6 serum levels have been reported in a variety of autoimmune diseases, including rheumatoid arthritis and inflammatory bowel disease. The purpose of this study was to evaluate IL-18 and IL-6 serum levels in DM and PM patients compared to a healthy control group..
    Patients and
    Methods
    In this cross-sectional study, 15 patients with DM, 5 patients with PM, and 20 healthy control subjects were recruited. The levels of serum IL-18 and IL-6 in patients and control groups were measured by using ELISA assay. Blood tests were taken to determine the levels of C-reactive protein (CRP) and creatine kinase (CK) and were measured by standard methods. Statistical analyses were performed using the Mann-Whitney U-test with a non-Gaussian population using SPSS 19 software..
    Results
    IL-18 levels were significantly higher in DM patients and PM patients before treatment compared to healthy control subjects (P = 0.001, P = 0.01, respectively). There were no significant differences between DM and PM patients before treatment with healthy controls for IL-6 serum levels (P = 0.51, P = 0.43, respectively)..
    Conclusions
    Serum IL-18 contributes to the immunopathogenesis of DM and PM and would be a useful marker for the diagnosis and treatment of diseases. IL-6 has a less pivotal role in the pathology of DM and PM..
    Keywords: Dermatomyositis, Polymyositis, Interleukin, 18, Interleukin, 6
  • Ali Garavand, Mahnaz Samadbeik, Mojtaba Kafashi*, Shahabeddin Abhari Page 4
    Context: The implementation and operation activities related to electronic health records (EHRs) have increased in different countries, and their importance is clear. However, the deployment of an EHR system depends on many factors that must be considered during implementation. The goal of this study was to identify and classify the challenges related to EHR deployment..
    Evidence Acquisition: The present study involved a literature review that was carried out through a search on the ISI, PubMed, DOAJ, Scopus, Science Direct, and Google Scholar databases, as well as the Google and Yahoo search engines, using the relevant MeSH keywords and focusing on the period of 2005 - 2015. The data were collected in an Excel file and analyzed based on the study objectives..
    Results
    From the investigation of related articles, we found that the deployment of EHRs faces many challenges that can be classified into six main categories. These are economic, behavioral, human, technical, legal, and organizational challenges..
    Conclusions
    With regard to the obtained results, it is recommended that the authorities put effort into resolving the economic, behavioral, human, technical, legal, and organizational challenges related to the implementation and deployment of EHRs..
    Keywords: Medical Informatics, Health Information Systems, Electronic Health Records