مجله دانشکده علوم پزشکی نیشابور
پیاپی 9 (زمستان 1394)

Introduction and Aims :Diabetes is a metabolic disorder, which is characterized by hyperglycemia resulting from defects in insulin secretion and impaired pancreatic function. Regarding to the medicinal properties of amaranth, this study was conducted to investigate the effects of amaranth on skin histomorphological changes in diabetic rats.
In this study, 48 male Wistar rats were divided into four groups (control group, sham group, first experimental group, and second experimental group). In these rats, an injured area of 3cm2 was created on the left spine. Wound healing was evaluated macroscopically.
Wound healing in group that became diabetes using streptozocin, showed late recovery compared to normal wound healing in normal groups and wound healing in experimental groups treated with alcohol extract of sesame was accelerated compared to control group.
Results of this study showed that alcohol extract of sesame causes accelerated skin wound healing in normal and diabetic samples.

Introduction and Aims: Toxoplasmosis is a usual infection caused by the intracellular protozoan parasite Toxoplasma gondii. Primary infections during pregnancy are usually asymptomatic for the pregnant woman but can cause severe neonatal problems. This study designed to determine seroprevalence of IgG and IgM and its related factors among first trimester pregnant women referring to health centers of Razavi Khorasan Province, Iran.
In this cross sectional study 786 serum samples were collected from pregnant women aged from 15 to 46 years in Khorasan Razavi province, during 2013-2014. The seroprevalence IgG and IgM antibodies were measured by using of commercial kit in both urban and rural areas and data were analyzed using the SPSS v.19.
The seroprevalence of IgG antibodies to T. gondii was 31.17% while IgM seroprevalence was 5.47% and 1.65% were positive for both IgG and IgM antibodies. The seroprevalence of T. gondii is directly proportional to the age, but inversely proportional to education and there was not any significant difference between urban and rural areas.
Sero-prevalence of T.gondii-specific antibodies is nearly high among pregnant women in Razavi-Khorasan province with a significant ratio of women at risk of T. gondii infections. Screening of T. gondii infections during antenatal care should be considered in this area as the chief strategy to diminish congenital toxoplasmosis.

Introduction and Aims: This study was conducted to determine the demographic characteristic and patterns of drug abuse in Quchan.
This study was a descriptive cross sectional study of the characteristics of 753 volunteer addicts whom admitted to detox centers of Quchan during one year. The collected data was analyzed using the SPSS v.16 software.
75% of 753 dossiers were due to men. Most of them (86.1%) were married and 32.4% were aged between 30-39 years. More than 50% of participants were illiterate and primary education that majority was self-employment. Opium sap, opium, crystal and heroin were the most commonly used addictive drugs. The main ways of consumption were fumigation (66.5%), eating (32.8%), and injection (0.26%) and snuff (0.39%). There were no cases of inhalation and drink. Opium sap and opium were the first addictive drugs that were reported by addicts. 60.2% of participants had a history of abandonment.
More research is needed to better understand the epidemiological of addictive drug users in the province and other cities.

Introduction and Aims: Multiple Sclerosis (MS) is a chronic disease of the central nervous system that affects motor pathways, leading to muscle weakness and muscle fatigue. The purpose of the present study was to investigate the influence of 8 weeks of combined (resistance and proprioceptive neuromuscular facilitation) training on the muscle strength, the balance and functional capacity in patients with MS.
To this end, thirty-seven male and female subjects with Multiple Sclerosis were randomly-purposefully assigned to the experimental (N=19, Age=34.53±6.51, Weight=67.02±13.14, EDSS=2.55±1.21) and control (N=18, Age=36.78±4.93, Weight=66.92±10.13, EDSS=2.88±0.97) groups. The experimental group received a combined (resistance and proprioceptive neuromuscular facilitation) training program for 8 weeks. In the experimental group, the muscular strength, balance and functional capacity of the subjects were measured before and after the training protocol. The collected data were analyzed using paired sample T-test at α = 0.05 level of significance.
The results of the study showed that there was a significant increase in general strength (P=0.001), upper strength (P=0.001), dominant leg balance (P=0.003), non-dominant leg balance (P=0.001) and gait endurance (P=0.001) factors, while there was observed no increase in the gait speed factor (P=0.12).
Based on the findings of the present study, a period of combined training produced a significant increase of strength, balance and distance of walking. Therefore, it is suggested that this type of training be considered as a part of the intervention in the rehabilitation program to improve the physical condition of the patients.

Introduction and Aims: Gastrointestinal cancers (GI) are considered as the most common cancer among men and are the second in women. The aim of this study was to evaluate the changes in crude and age specific incidence rates of gastrointestinal cancers in Neyshabur during 2006-2012.
In this study the recorded data of Neyshabur’s patients with cancer in the hospitals of Mashhad and Neyshabur were analyzed using Excel and SPSS v.16. Crude and age specific incidence rates were also estimated.
ree hundred and thirty-five (42.8%) out of all 783 patients with cancer, were GI cancers. Gastric cancer showed the highest prevalence (41.8%) with the rate of 63.3 and 36.7 percent in men and women respectively. The results indicated the incidence of gastric cancer had a falling tendency.
out half of all the cancers in Neyshabur are of the GI type and their incidence rate up to 2012 showed a decreasing trend so that, this rate is higher in men and older age groups. This decline may be due to numerous reasons such as control of risk factors, failure to identify eligible patients, referring to medical centers outside the province, or an increase in mortality and etc. that needs further investigation.

Introduction and Aims: This study is examining the effect of Q10 supplementation on some oxidative and anti-oxidative markers following one bout exhaustive aerobic exercise in sedentary men.
20 sedentary men divided in 2 homogenous groups in double blind approach: supplementation group (2.5mg/kg Q10) and placebo group. Subjects participated in Bruce test after 14 days Q10 supplementation. Blood samples were collected 4 times.
The results show significance increase in total anti oxidative capacity following 14 days Q10 supplementation (P It is concluded that Q10 supplementation could prevent exercise induced oxidative stress following one bout aerobic exhaustive exercise by increasing the total anti oxidative capacity in sedentary men.

Introduction and Aims: The main cause of death in the adult population in the industrialized world is sudden cardiac arrest. The first purpose of cardiopulmonary resuscitation is return of spontaneous circulation. Post cardiopulmonary resuscitation cares are fifth stage of American Heart Association cardiopulmonary resuscitation that less take into consideration. Therefore, the present study was conducted with the aim of “24 Hour Survival Rate and it’s determinants in patients with Successful Cardiopulmonary Resuscitation in Ghaem Hospital of Mashhad”.
In this descriptive and analytical study, 80 cases of CPR were selected by convenience sampling in Ghaem hospital of Mashhad. After confirming of cardiac arrest by a resident physician in the wards and declaration of code 99, were performed cardiopulmonary resuscitation by CPR team. Rate of 24 hour survival was determined in patients that had return of spontaneous circulation by form the researcher’s observations. Data were collected and analyzed using of descriptive statistics (frequency, mean, standard deviation) and inferential statistics (Fishers, Chi-square, logistic regression) and SPSS software version of 16.
Mean and standard deviation of age patients was 67.3±1.5 year. In 45 patients (56.2%), was achieved return of spontaneous circulation. The rate of 24 hour survival was in 30 patients that cardiopulmonary resuscitation on them was successful. The chi-square test, showed that is significant differences between 24 hour survival with sex and diabetes in patients (P The rate of 24 hour survival was 66.7% in patients with a successful cardiopulmonary resuscitation. This reflects that must be considered after cardiopulmonary resuscitation cares.

Introduction and Aims: Proteinuria means the presence of an excess of serum proteins in the urine that is very important to achieve accurate and reliable results to the physicians. The aim of this study was to evaluate the interference of turbidity in the measurement of 24-hour urine protein before and after cold treatment in turbid centrifuged samples.
This experimental study was performed in ACECR (Academic Center for Education, Culture and Research), that was conducted on a random sample of 1000 people in 2015 March to September. The measurement of 24-hour urine protein was performed by using three chloral acetic acid method (TCA) and photometer.
Ten samples (1%) just were turbid after centrifuge. There was a significant difference (P In order to deposit interfering factors, the urine samples that are taken to measure protein and are turbid after centrifuge should be given cold treatment and centrifuge again.