فهرست مطالب

  • Volume:18 Issue: 2, 2017
  • تاریخ انتشار: 1395/11/30
  • تعداد عناوین: 5
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  • Ali Maher, Mohammadkarim Bahadori *, Ramin Ravangard Page 1
  • Zahra Rezaieyazdi, Nastaran Hashemi, Zahra Mirfeizi *, Maryam Sahebari, Narges Hashemi Page 2
    Objectives
    In recent years, there is some evidence that adipokins play an important role in autoimmunity and inflammation. Resistin is the novel adipocyte-derived peptid and the aim of this study was to compare its serum values in lupus patients and controls..
    Methods
    A cross sectional study was carried out on 73 patients with the definite diagnosis of SLE. Resistin and other proinflammatory markers were compared between patients and normal age and sex match individuals..
    Results
    There was no significant difference in serum resistin, concentrations, between patients and healthy individuals (6.88 ± 4.53 and 6.74 ± 3.74 ng/mL respectively, P = 0.704). Statistical analysis showed a positive correlation between serum, levels of resistin with CRP and ESR (P ≤ 0.008 and P ≤ 0.037 respectively), in SLE patients. Higher serum levels of resistin in patients with proteinuria were found in comparison with normal kidney patients (P = 0.022). But there was no relationship between resistin like SLEDAI score..
    Conclusions
    Resistin was associated with in inflammatory markers but not a notable association with markers of disease activity has been detected..
    Keywords: Systemic Lupus Erythematosus, Adipokine, Resistin, Inflammation
  • Ali Javadpour *, Mohammad Reza Shenavar, Mina Dehghani, Mohammad Jafar Bahredar Page 3
    Background
    While psychological and behavioral symptoms are a major challenging aspect of dementia, they have not been considered as an important mental health issue in developing countries. The aim of the current study was to explore the prevalence and possible associated factors of psychiatric symptoms seen in patients with dementia..
    Methods
    In a cross sectional study, 101 patients diagnosed with dementia were selected. Appropriated world-wide instruments, such as the Neuropsychiatry Inventory (NPI), Clinical Dementia Rating scale (CDR), barthel index and Cummulative Illmess Rating Scale (CIRS) were used to detect behavioral disturbance, severity of dementia, disability and burden of medical conditions, separately. In this study, the correlation between Behavioral and Psychological Symptoms of Dementia (BPSD) and severity of dementia, activity of daily living, organic dysfunction and type of dementia was also evaluated..
    Results
    Behavioral and Psychological Symptoms of Dementia were frequent in about 70% of the study sample. The most common problematic behaviours were night time behaviours followed by delusion (58%), disinhibition (57%), anxiety (57%), irritability (56%), depression (55%), agitation (55%), and apathy (55%). The least frequent symptom was elation. These behavioral symptoms were significantly correlated with the severity of dementia, greater disability, higher burden of medical conditions, and the level of distress in both patients and their caregivers. Mood symptoms such as depression, anxiety, and elation were not increased with the severity of the dementia..
    Conclusions
    The findings of this study suggested that the three main cluster symptoms were psychosis, behavioral disturbances such as disinhibition, irritability agitation and, mood symptoms including anxiety and depression..
    Keywords: BPSD, Dementia, Iranian Elderly
  • Fatma Nihan Turhan Caglar *, Nilgun Isiksacan, Nursel Kocamaz, Faruk Akturk Page 4
    Background
    Vitamin D deficiency is common in patients with body mass index (BMI) higher than 25 kg/m2. The aim of this study was to evaluate whether any correlation exists among 25 hydroxyvitamin D, BMI, and other biochemical parameters in Turkish women subjects..
    Methods
    A total number of 31 subjects with BMI ≥ 25 kg/m2 were included. These patients were, subsequently, divided into 2 groups according to their BMI. Group 1 consisted of patients with BMI:25 - 34 kg/m2 and group 2 with BMI ≥ 35 kg/m2. Venous blood samples were collected from the subjects in a morning fasting state to measure serum Vit D levels. high performance liquid chromatography-mass spectrometry (HPLC-MS) method was used for Vit D measurement. The homeostatic model assessment (HOMA) was used to quantify insulin resistance (IR)..
    Results
    A total number of 15 subjects (46.9%) had BMI 25 - 34 kg/m2 (group 1) and 17 subjects had BMI ≥ 35 kg/m2 (group 2). Vit D levels were 24.82 ± 13.7 ng/mL in group 1 and 23.56 ± 12.31 ng/mL in group 2. Although Vit D levels were lower than normal limits in both groups, they were not statistically different among the groups (p 0.901). Although statistically insignificant, insulin levels were higher in group 2 than group 1 (19.68 ± 7.91 µU/mL vs 17.6 ± 12.02 µU/mL; P = 0.29) and insulin levels were negatively correlated with Vit D (r = -0,631; P = 0,002; P
    Conclusions
    We demonstrated decreased Vit D levels and a negative correlation among serum insulin levels, HOMA-IR, and Vit D in Turkish obese women. Epidemiological studies, also, indicate that Vit D deficiency may be related with IR and the development of diabetes. Further studies are needed..
    Keywords: Vitamin D, Body Mass Index, Obesity, Insulin Resistance
  • Elahe Bayat, Sanaz Dastgheib, Somaye Egdar, Pooneh Mokarram* Page 5
    Background
    Diabetes, as a common chronic disorder, is the seventh leading cause of death in the world. This disorder is classified into two major types: type I and type II diabetes mellitus. Recently, researchers have identified a higher level of inflammatory cytokines in patients with type II diabetes, compared to the normal population. Today, plant-based therapies, given their anti-diabetic properties, have attracted the researchers’ attention. One of the medicinal plants with anti-diabetic effects is Stevia rebaudiana Bertoni. Various hypotheses have been proposed to explain how stevioside, as a derivative of Stevia rebaudiana, can cause such a significant decline in blood glucose level. To the best of our knowledge, the exact anti-inflammatory and immunomodulatory effects of the aquatic extract of stevia are not fully understood. Therefore, the current research aimed to evaluate whether stevia can improve the interleukin-6 (IL-6) level in streptozotocin-nicotinamide-induced diabetic rats..
    Methods
    In the present study, a cohort of rats was divided into five groups, each containing 11 rats: (1) normoglycemic group, receiving 1 mL of water; (2) diabetic control group, receiving 1 mL of water; (3) and (4) diabetic groups treated with the aquatic extracts of stevia (400 mg/kg) and metformin (500 mg/kg), respectively; and (5) healthy group treated with the aquatic extract of stevia (400 mg/kg). At the end of the experiment, the rats were sacrificed and blood samples were collected from the heart for evaluating serum IL-6 changes. Statistical analysis was performed, using one-way analysis of variance (ANOVA), followed by the least significant difference (LSD) post-hoc multiple comparison test..
    Results
    The present results showed that IL-6 (P = 0.001) and fasting blood sugar (FBS) (P
    Conclusions
    Based on the findings, inflammation can be ameliorated with the whole aquatic extract of stevia, as an anti-diabetic compound. Therefore, by considering IL-6 level as an indicator of insulin resistance, stevia can lead to a decline in IL-6 level and thereby reduce insulin resistance in diabetic patients..
    Keywords: Diabetes Mellitus, IL-6, Aquatic Extract, Stevia Leaves, Rat