مجله تعالی بالینی
سال ششم شماره 1 (پیاپی 12، پاییز 1395)

Tooth eruption order is regular in most of children but not following the normal growth of the teeth should not always be considered abnormal. Exfoliation of deciduous teeth and eruption of permanent teeth are an important stage for child’s parent and dentist. Exfoliation of teeth is dental evolutionary movement in the axial direction from its formation origin in the bone until initiating its activity in the mouth. Attention to the findings of the physical examination, the presence or absence of developmental disorders, hydrocephalus, rickets, and cleft lip and palate, and anomalies, can indicate the presence of underlying genetic diseases or endocrine disorders. In other words, teething is a component of body growth and development which is influenced by various factors, serum levels of calcium and vitamin D, and underlying diseases. Careful attention of dentists to the various signs of eye, face, skeletal, cardiac and growth disorders in children and counseling, if needed, can help them in early detection of underlying disorders. Knowing the eruption time of permanent teeth helps the dentist to identify accelerated or delayed eruption of the teeth and evaluating its causes.

The last two decades has increased dramatically drugs proton pump inhibitor (PPI: Proton Pump Inhibitors) in children and adults, so that increase 4-fold in the prevalence of PPI between 2003-2000 in infants, with existed an estimated increase of 7.5 years from 2004 to 1999. Several studies have been conducted on adult patients that There are relationship between antiacid and infectious diseases (pneumonia and infections of the gastrointestinal) and non-infectious diseases (pelvic fractures and a deficiency of vitamin B12). This finding challenges the methods of experimental treatment an antiacid drugs in cases of suspected GERD in infants and children. Accordingly, the present study was to evaluate the side effects associated with medications of antiacids in the pediatric population.
This study was a review and search the database based on Magiran SID, Medlib, Iranmedex, proquest Elsevier, Ovid, PubMed, Science direct. 52 articles were found and finally 12 articles were related to the purposes of this study. Articles were Inclusion criteria that the relationship between drugs inhibit acid secretion show the risk of Necrtizing enteracolitis, sepsis, bacteremia, pneumonia and infections of the gastrointestinal. It can be concluded that PPI and H2bloker should be used in both children and adult with caution.

Pervasive Education as an efficient method has been drawing increasing attention in the recent years. To provide equal educational facilities for all children in the society is of the basic principles of the educational system in Iran.After family, educational system exerts the highest influence on an individual's development, based onwhich there are two general approaches where the one dealing with providing service for all individuals in such a manner that no one is isolated from the ordinary background of the society is considered the appropriate one .As the population of the country declines and the required work force in future needs to increases, the children with special needs and capabilities can be benefitted in society. Based on this, they have to be particularly focused.
The method applied in this study is analytical. A comprehensive review has been done with all the words onexceptional children, coed schools, pervasive education in the databases - Iran medex, Since directGoogle scholar, SID- stressing domestic researches. The findings indicate thatthe negative attitude of the teachers toward attracting and covering the children with special needsimpedes the implementation ofmaking the pervasiveprojectto be realized. Crowded classrooms, lack of suitable space,lack of rehabilitation services andinadequately monitoring the peer's negative relationships is of other barriers. Of course, the studies suffer from some drawbacks like being done on a certain group and that most of them were done in the initial stages of the project. Generally speaking, we need to implement the project in all centers and then to follow up its challenges. It is imperative to train the average teachers and the liaison ones and solve their problems, help them to modify their attitude and invite their parents to cooperate.

Curcumin is a polyphenolic compound that has yellow color and extracted from the root plant of curcuma longa. In East traditional, this compound is widely used for the treatment of various diseases. In recent years, much attention of modern medicine to this compound, led an extraordinary and remarkable properties of this material is proved. Curcumin has a wide range of health benefits, such as antioxidant, anti-inflammatory, antiseptic, anti-microbial and anti-viral, anti-cancer and etc. In addition to its therapeutic effects, clinical traial studies on the oral dose of curcumin have demonstrated that curcumin intake to 8 gr/day has no toxicity to the body. These properties, with the lack of toxicity, caused this unique compound seriously be attractive for pharmaceutical research centers. In recent years, the therapeutic effects of curcumin in particular on cancer, has been investigated. Despite these excellent properties, curcumin consumption faced with serious limitations. Curcumin has a low solubility in aqueous solvents (about 20 micrograms per milliliter). It also quickly destroyed in the physiological PH. this problems makes that Curcumin has low bioavailability and poor pharmacokinetics. To overcome these problems, great efforts were made to improve the solubility and stability of curcumin. For this purpose, several formulations have been done based on the encapsulation of curcumin, such as polymeric nanoparticles and nano-gels, surfactants, proteins, liposomes, phospholipids, conjugate, and etc. In many cases, these efforts have been associated with satisfactory results.

Recent investigations have shown that consumption of palm date could be effective on labor parameters. Also Holy Quran, Islamic Hadiths and narrations has encouraged consumption of palm date during pregnancy, labor and after that. So, this study aimed to review the effects of palm date consumption on labor parameters from the perspective of Islam and modern medicine. This review was done by searching on PubMed, Science Direct, Scopus, Web of Science, Ebesco, Embase, and ISC by entering Phoeniceae, Phoenix dactylifera, Palm, Date Palm, Date Palm Fruit, Date Fruit, Labor Onset, Pregnancies, and Gestation as keywords. In this study, clinical trial studies which were published until May 2017 were reviewed. We included studies that were done on human. Based on findings, date consumption can lead to increase of cervical dilation and effacement, and onset of spontaneous labor, and decrease need to induction with oxytocin, duration of gestation, duration of labor and postpartum hemorrhage. Results indicated that in line to verses of 23-26 Surah Maryam and Islamic hadiths and narrations, date could be consume as a natural and non-expensive, available and without side effects substances to facilitate delivery and labor.

Periodontitis is a chronic infectious disease with high prevalence among humans. Diabetes and periodontitis interact on each other. These two diseases can also stimulate the production of specific inflammatory cytokines.
The IL23 / IL17 axis plays an important role in the progression of chronic inflammation and host responses to bacterial infections. For this purpose, we study aimed to investigate the relationship between IL 23 articles with both disease(periodontitis, diabetes) tested, too.
The present study was a review study based on Magiran, Medlib, Iranmedex, SID proquest, Elsevier, Ovid, Pubmed, Science Direct databases. The Persian and English related articles were used during the period 2000-2017, which was written about periodontal disease, diabetes and IL 23.
Only four articles were found that investigated the association of IL-23 with both disease(periodontitis, diabetes). Two clinical trials and two case-control studies were conducted. Two studies of IL-23 levels in Gingival Crevicular Fluid(GCF), a study in serum and a study of the incidence of IL-23 mRNA in patients undergoing biopsy in gingival tissue, were studied. Only in one study, the reduction of IL-23 levels in the treated group was observed in the non-treated group, and in other studies, IL-23 levels were not significantly different among the groups.
In order to obtain more accurate clinical outcomes in this field, it may be worthwhile studying to measure the level of this cytokine in serum, saliva, and gingival fluid of this substance by simultaneous gingival biopsy of affected areas. In addition, clinical trials with sample size and control groups should be more effective.

Demand for consumption of functional food is growing and various ingredients are incorporated into these foods that besides supplying basic nutritional needs can enhance health level or decrease the incidence of diseases. Glycomacropeptide (GMP) derived from cheese whey is one of the bioactive compounds that can be utilized in functional food development. GMP is a heterogeneous peptide of 64 amino acids formed by hydrolysis of ƙ-casein between Phe105 and Met106 using rennet during cheese production and exerts various beneficial biological properties. Literature research regarding the beneficial characteristics of GMP was performed with English and Persian keywords in different databases without any limitation in time. 70 articles were obtained and finally 48 articles between 1980-2016 were reviewed. Results revealed that GMP can prevent adhesion of infectious bacteria to intestinal epithelium as well as cariogenic bacteria to oral surfaces. Consumption of GMP in the diet leads to reduction of gastric secretions and Cholecystokinin resulting in satiety. GMP can be used in dietary management of individuals with phenylketonuria (PKU) that lack the enzyme phenylalanine hydroxylase because of its low amount of phenylalanine. Furthermore, prebiotic activity, modulation of immune system and increasing bioavailability of minerals are the other useful effects of GMP. Therefore designing pharmaceutical or food formulation by using GMP based on the mentioned healthful properties can help markedly to improve the health status of individuals.