- Volume:1 Issue: 3, Summer 2017
- تاریخ انتشار: 1396/09/25
- تعداد عناوین: 8
Expression of Bcl-2 and p53 protein in Stomach Cancer Patients and Association with Clinicopathological FactorsPages 1-7IntroductionStomach cancer is one of the most common cancers worldwide. Bcl-2 and p53 appear to be important biomarkers in patients with stomach cancer. In this study, we investigated the expression of Bcl-2 and p53 proteins and its association with clinicopathological factors in 67 Iranian stomach cancer patients over a 5-year period (2010-2015).
Material andMethodsIn this cross sectional study, the expression of the Bcl-2 and p53 protein was determined using immunohistochemistry, and the pathological features of tumors were evaluated.ResultsThe expression of Bcl-2 and p53 proteins was detected in 47% and 48% of the patients, respectively. Of the 67 patients, 39 patients had intestinal-type gastric adenocarcinoma, and 57 patients had grade І and ΙΙ. There was a statistically significant association between Bcl-2 and p53 expressions (P=0.04).ConclusionsThere is an association between Bcl-2 and p53 protein expressions in patients with stomach cancer. Bcl-2 and p53 protein expressions are more frequent in high-grade tumors. Bcl-2 and p53 expression might play an important role in the early development and phenotypic differentiation of gastric carcinomas, but not so in tumor progression.Keywords: Stomach cancer, P53protein, Bcl-2 protein, Expression, Immunohistochemistry (IHC)
Psychosocial and Work-Related Factors Associated with Musculoskeletal Pain among Office Workers in Gorgan, North of IranPages 8-14IntroductionMental health refers to emotional and psychological well-being, impairment of which may adversely affect an individual's cognitive or social functioning, making it harder to cope with the demands of daily life. According to the biopsychosocial paradigm and, common psychological symptoms, such as low mood, importantly influence the occurrence and prognosis of musculoskeletal pain. The aim of this study is to survey of association musculoskeletal pain with Psychosocial and work-related factors among office staff in Gorgan.
Methods and Material: This descriptive and analytical study was performed among office workers in Gorgan in 2016. By cluster sampling method 675 office staff was included to be interviewed from the 18 occupational sectors. Data were collected on individual factors, negative affectivity, workplace factor, work station and task demand, psychosocial risk factors, work environment and experience of pain during the past 12 months. With Nordic Musculoskeletal Questionnaire (NMQ-E, Self-Administered Physical Activity Survey and the standardized Dutch Musculoskeletal Questionnaire. Data were analyzed by logistic regression in spss version 16.ResultsAmong all participants, 17.3 % reported neck pain, and it was 8.4 % and 20% for shoulder and low back pain, respectively. Moreover, 6.4% of these patients had pain in more than one body area. Factors including adjusted back rest on chair, work with bent head, hours worked per week and also supervisor support and sex were significant for the neck pain (pConclusionExcessive use of the computer system combined with a poorly designed workstation, repetitive computer work, lack of rest time at work, the role of individual factors such as age, sex, and lack of awareness of the dangers of environmental and psychosocial factors in workplace formed risk factors that are associated with musculoskeletal disorders, then, it is basically necessary to identify mentioned factors to solve and improve disorders.Keywords: Musculoskeletal Disorders, Psychosocial Disorders, Pain
Prevalence of Corneal Arcus in Patients Younger Than 50 Years with Non-Alcoholic Fatty Liver Disease in Gorgan, Northeast of IranPages 15-19IntroductionCorneal arcus caused by lipid deposition around the cornea has been proposed as an early marker for several metabolic disorders and even cardiovascular events. Non-alcoholic fatty liver (NAFLD) is a common health problem diagnosed by elevated liver enzymes and abdominal ultrasound findings. This study was conducted to assess the prevalence of corneal arcus in patients with NAFLD in Gorgan, northeast of Iran.Materials And MethodsThis cross-sectional study was performed on 200 NAFLD patients younger than 50 years of age who were referred to hospitals of Gorgan between March 2014 and February 2015. Diagnosis of NAFLD was based on liver function test and abdominal ultrasound examination. Presence of corneal arcus was evaluated by slit-lamp examination.ResultsOverall, corneal arcus was found in 91 patients (45.5%). Presence of corneal arcus was significantly correlated with smoking, opium consumption and family history of NAFLD. After controlling the confounding variables )diabetes, hypertension, smoking, hyperlipidemia, age, gender, ethnicity and body mass index(, we found that corneal arcus is significantly associated with history of ischemic heart disease and family history of fatty liver disease.ConclusionsPresence of corneal arcus in patients younger than 50 years with NAFLD is significantly associated with having a history of ischemic heart disease and family history of fatty liver disease.Keywords: Corneal arcus, Non-alcoholic fatty liver disease (NAFLD), Liver enzymes
Pages 20-24IntroductionAlthough the exact incidence rate of vaginal atresia is not clear, studies show that this disorder is often accompanied with imperforate hymen associated with hydrocolpos. We reported a 30-day-old infant with vaginal atresia and hydrocolpos secondary to imperforate hymen who went under a two-stage vaginoplasty for treatment.
Case description: The patient was a 30-day-old female infant who was referred to the Taleghani Hospital in Gorgan with symptoms of abdominal distension and urinary retention, in 2016. The patient went under emergency laparotomy. A large hydrocolpos was observed in the initial exploration. Fluid within the hydrocolpos was drained. A week later, the second surgery was done for vaginal repair and hymen reconstruction.ConclusionWe performed a two-stage vaginoplasty that consisted hydrocolpos drainage in the first stage and hymen repair by cruciate incision in the second stage. Early use of imaging techniques and surgical treatment can prevent the secondary complications of the disorder such as hydronephrosis and sepsis.Keywords: vaginoplasty, hydrocolpos, vaginal atresia, imperforate hymen
Effects Of Zno Nanoparticles on Initial Adhesion and fimH Gene Expression Level of Uropathogenic Eschercia coliPages 25-28IntroductionUropathogenic Escherichia coli (UPEC) strains are the main causes of urinary tract infections. Adhesion is one of the main and primary steps of UPEC pathogenicity. Type 1 fimbriae is one of the bacterial surface structures that plays an important role in bacterial adhesion. The aim of this study was to evaluate effects of ZnO nanoparticles on the initial adhesion and fimH gene expression level of UPEC.Materials And MethodFour UPEC isolates were used in this study. All isolates were exposed to sub-minimum inhibitory concentration of ZnO nanoparticles (1250 μg/ml). Expression of the fimH gene was evaluated by Real-time PCR.ResultAccording to the results, presence of nanoparticles reduced the fimH expression level in all four isolates. The highest and lowest rates of down-expression were 1.4-fold and 16.37-fold, respectively. Moreover, these results were consistent with phenotypic observations.ConclusionHowever, it is recommended to conduct further studies on gene expression and bacterial adhesion to surfaces to prove whether ZnO nanoparticles could completely prevent UPEC adhesion.Keywords: UTI, UPEC, ZnO nanoparticle
Pages 29-35IntroductionNowadays, musculoskeletal disorders (MSDs) are one of the most common work-related problems in the world. The aim of this present study was to determine the prevalence of MSDs and their relationship with work-related factors among tutors working at Shahid Sadoughi University of Medical Sciences in Yazd, Iran.Materials And MethodsThis cross sectional study was conducted on 113 tutors at the Shahid Sadoughi University of Medical Sciences in 2015. Data were collected by a standard self-administered questionnaire consisting of three major parts: a) demographic and work-related variables, b) musculoskeletal symptoms, c) a modified version of the Standard Nordic Questionnaire. The data were analyzed by SPSS (version 16) using appropriate statistical tests. P-values less than 0.05 were considered statistically significant.ResultsPain in the low back (27.9%) and neck (25%) was the most common complaint among the subjects. Overall, 80 tutors (70.79%) had symptoms of pain in at least one part of the body in the past year. The highest rate of complaints was related to laboratory tutors (94.73%). There was a statistically significant association between prevalence of MSDs and teaching time.ConclusionsThe prevalence of MSDs among faculty members of Shahid Sadoughi University of Medical Sciences is high and more than the general population. The musculoskeletal complaints are significantly associated with teaching time.Keywords: Work-related complaints, Musculoskeletal disorders, Medical teachers
The «well- being» of Hemodialysis patients referred to the hospitals of Zahedan University of Medical Sciences (South-East of Iran)Pages 36-42Introductiondue to the Importance of identifying different aspects of well- bing in Hemodialysis patients, this study aimed at determining well- being and its dimensions in Hemodialysis patients referring to Hospitals of Zahedan University of Medical Sciences in 2016.
Material andMethodsThis descriptive analytical study was performed among 129 patients with Hemodialysis by the use of census .The data-gathering instrument was a two part questionnaire. In the first part, there were questions about socio-demographic characteristics (7 questions) followed by the second part which was a standard questionnaire related to well- being and Hemodialysis (36 questions). The reliability and validity of the questionnaire were evaluated. In order to analyze the data, we made use of SPSS software and descriptive statistics such as mean, standard deviation and analytical tests including independent t-test, ANOVA and Pearson correlation coefficient. The significance level was set in 0.05 (p ˂0.05).Resultsthe study showed that the mean score of total emotional well-being was 138.95±21.9. There were statistically significant correlations between gender and spiritual dimension (p=0.03), between educational level and physical (p=0.04) and mental dimensions (p=0.03), family income was significantly correlated with mental (p=0.04), social (p=0.03) and intellectual dimensions (p=0.03). Moreover, Emotional well-being had the highest correlation with mental dimension (pConclusionthe current study revealed that the mean score of well- being was more than average. Furthermore, the factors such as gender, educational level and income level are known as the factors affecting emotional well-being in patients affected by Hemodialysis. Therefore, paying special attention to these patients needs can lead to useful outcomes and will promote the patients life quality.Keywords: well- being, Hemodialysis, Patients
Pages 43-46IntroductionCrigler-Najjar syndrome is a rare autosomal recessive genetic disorder with incidence rate of one per a million live births. This syndrome often causes permanent damage to the nervous system due to high bilirubin level. We hereby present a child with Crigler-Najjar syndrome type I (CNS-I).
Case description: The patient was an 18-month-old male infant referred to Taleghani Hospital in Gorgan due to jaundice at the first week of birth. CNS-I was confirmed by detecting high level of non-conjugated bilirubin. The patient was the second child of a consanguineous marriage (between cousins). The first child of the family was aborted in the first pregnancy due to infection. The patient underwent liver transplantation at age of six months. Renal and kidney ultrasound showed no abnormality. The patient was hospitalized several times due to fever and rectorrhagia following the liver transplantation, and eventually died of lymphoproliferative disorder.ConclusionsEarly diagnosis at birth and therapeutic interventions including liver transplantation in the early months after birth could prevent the most common and dangerous complication of the disease, kernicterus. Therefore, early diagnosis and follow-up are of great importance in patients survival. Moreover, genetic counseling should be provided for consanguineous couples.Keywords: Crigler -Najjar Syndrome, Hyperbilirubinemia, Liver transplant, Newborn