فهرست مطالب

Journal of Analytical Research in Clinical Medicine
Volume:2 Issue: 1, Winter 2014

  • تاریخ انتشار: 1392/12/20
  • تعداد عناوین: 7
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  • Mohammad-Hossein Biglu*, Sahar Biglu Pages 1-10
    Introduction
    Bipolar disorder is a psychiatric condition that is also called manic-depressive disease. It causes unusual changes in mood, energy, activity levels, and the ability to carry outday-to-day tasks. In the present study, 3 sets of data were considered and analyzed: first, allpapers categorized under Bipolar Disorders in Science Citation Index Expanded (SCI-E)database through 2001-2011; second, papers published by the international journal of BipolarDisorders indexed in SCI-E during a period of 11 years; and third, all papers distributed by theinternational journal of Bipolar Disorders indexed in MEDLINE during the period of study.
    Methods
    The SCI-E database was used to extract all papers indexed with the topic of BipolarDisorders as well as all papers published by The International Journal of Bipolar Disorders. Extraction of data from MEDLINE was restricted to the journals name from setting menu. TheScience of Science Tool was used to map the co-authorship network of papers published byThe International Journal of Bipolar Disorders through 2009-2011.
    Results
    Analysis of data showed that the majority of publications in the subject area of bipolardisorders indexed in SCI-E were published by The International Journal of Bipolar Disorders. Although journal articles consisted of 59% of the total publication type in SCI-E, 65% ofpublications distributed by The Journal of Bipolar Disorders were in the form of meetingabstracts.Journalarticlesconsistedofonly23%of the totalpublications. USA was theleadingcountryregardingsharingdatainthefieldofbipolardisordersfollowedbyEngland,Canada,andGermany.
    Conclusion
    The editorial policy of The International Journal of Bipolar Disorders has beenfocused on new themes and new ways of researching in the subject area of bipolar disorder. Regarding the selection of papers for indexing, the SCI-E database selects data morecomprehensively than MEDLINE. The number of papers published by The Journal of BipolarDisorders, which has been indexed in SCI-E was 2 times greater than the number published inthe same journal indexed in MEDLINE during the same period.
    Keywords: Bipolar Disorders, MEDLINE, SCI-E
  • Sousan Rasouli*, Farnaz Moslemi Pages 11-16
    Introduction
    The incidence of cesarean section has increased in most countries in recent years. Anesthetic methods used during cesarean section have some advantages anddisadvantages to both mother and neonate. In this study, for comparison of general and spinalanesthesia we evaluated the short-term outcome of neonates born through cesarean section.
    Methods
    Retrospectively, we studied 324 mothers undergoing cesarean section with generalor spinal anesthesia. Data were obtained including maternal age, gravidity, parity, and reason of cesarean section. Maternal systolic and diastolic blood pressure, neonatal Apgar score 1and 5th minutes, the biochemical status and blood gases of arterial samples withdrawn from thecord. Furthermore, we evaluated the relation between the maternal blood pressure changeswith neonatal Apgar score and the sample of cord pH (Power of Hydrogen).
    Results
    Of 324 mothers undergoing cesarean section, 117 subjects (36.1%) had general and217 (63.9%) had spinal anesthesia. There were no statistical significant differences between the two groups regarding the demographic characteristic. The one minute Apgar score groupin the spinal anesthesia group was significantly higher than the general anesthesia group(P = 0.01). But there were no divergence between the two groups in five minute Apgar score.Mean fetal acidity in general anesthesia group was higher than the spinal anesthesia group, buttheir differences were not statistically significant. There were no statistical significantcorrelation between the maternal blood pressure and cord's arterial blood pH or neonatalApgar score.
    Conclusion
    The one minute Apgar score in spinal anesthesia group was better and fetalacidosis was lower than the general anesthesia group, but there was not any significant difference between the two groups regarding systolic and diastolic pressure, and there was nosignificant correlation between the maternal mean blood pressure, Apgar score and pH ofarterial cord samples. Thus, possibility of maternal hypotension and decreased uteroplacentalperfusion should not prevent the use of spinal anesthesia for cesarean section.
    Keywords: General anesthesia, Spinal anesthesia, Cesarean section, Apgar score, Cord's arterial blood gas
  • Jamal Halaj Zadeh, Amir Ghorbanihaghjo*, Hassan Argani, Shahnam Valizadeh, Najat Halaj, Amirmansour Vatankhah, Hakimeh Rezaei Aghdam Pages 18-24
    Introduction
    Inflammation is recognized in up to 50% of chronic kidney disease (CKD) patients, being a common feature of advanced renal disease and crucial mediator of vascularcalcification which may be relevant in CKD. This study was aimed at evaluating the role ofGrowth arrest-specific 6 (Plasma GAS-6) and mineral metabolism abnormalities inhemodialysis (HD) patients.
    Methods
    We enrolled a total of 92 adults including 46 (28 males and 18 females) clinicallystable HD patients and 46 (23 males and 23 females) patients with normal kidney as control group. Plasma GAS-6, Interleukin 6 (IL-6), and high sensitivity C-reactive protein (hsCRP)concentration and biochemical alteration were quantified; as biochemical factors, GAS-6,IL-6, and hsCRP levels were determined by standard methods.
    Results
    Levels of GAS-6 were significantly increased in HD patients compared with normalcontrols (P
    Conclusion
    Elevated serum P and GAS-6 might play a role in the development ofinflammation in CKD patients. Although our study shows that GAS-6 is directly associated with IL-6 and phosphor with hsCRP, their direct role in vascular calcification and type of theirrelationships need further studies in the future.
    Keywords: Hemodialysis_Growth Arrest-Specific 6 (GAS-6)_Interleukin 6 (IL-6)_High Sensitivity C-Reactive Protein
  • Esmaiel Fallah, Abbas Shahbazi*, Majid Yazdanjoii, Bahman Rahimi-Esboei Pages 25-29
    Introduction
    Amebiasis is an intestinal illness caused by a one-celled parasite (amoeba) called Entamoeba (E) histolytica. E histolytica and E dispar are morphologicallyundistinguishable but have genetic and functional differences. E. histolytica is invasive andcause amoebiasis, but E dispar cause an asymptomatic colonization which does not need to bemedically treated. We have performed a nested multiplex Polymerase Chain Reaction (PCR)targeting small subunit rRNA (Ribosomal ribonucleic acid) gene for differential detection of Ehistolytica and E dispar directly from stool samples.
    Methods
    All the fecal samples collected without preservation and were screened for amebiccells by parasitological methods. Fecal samples that containing amebic cells were stored at -20ºC until DNA extraction. DNA extraction was down by using a DNA extraction kit. Thegenus specific primers were designed using nucleotide sequences of 18S-rRNA gene ofEntamoeba.
    Results
    Thirty one (4.28%) stool samples out of 724 samples were positive for E histolytica/E dispar. The nested multiplex PCR illustrated that the size of diagnostic fragments of PCR products was obviously different for two Entamoeba species, the specific product size for Ehistolytica and E dispar was 439 and 174 bp. The nested multiplex PCR was positive in 25 outof 31 stool specimens that 17 (54.8%) samples were positive for E dispar and 8 (25.8%)samples were positive for E histolytica.
    Conclusion
    Nested multiplex PCR was useful for the specific detection of E histolytica and Edispar in stool samples. In current study we detected that E dispar was more prevalent in our study area.
    Keywords: E histolytica, E dispar, Nested Multiplex Pcr, Iran
  • Fatemeh Khaki-Khatibi, Naser Samadi*, Alireza Yaghoubi Pages 30-35
    Introduction
    The oxidative stress and inflammation are cooperative events involved in atherosclerosis development. In the present study, we assessed the association ofmalondialdehyde (MDA), antioxidant markers, high sensitive C-reactive protein (HS-CRP)and lipid status parameters in non-diabetic patients with coronary artery disease (CAD) orvessel heart disease (VHD). Significant risk factors such as diabetes were excluded from thestudy.
    Methods
    Oxidative stress parameters for example MDA, antioxidant markers including:erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC), inflammation marker and serum lipid status parameters were measured in 120 subjects including 60 CAD patients (non-diabetic) with angiographically diagnosed CADand 60 CAD-free subjects as a control group, also diabetic patients with malignancy, renal andliver disease, and other disease were excluded from the study.
    Results
    The serum MDA and HS-CRP levels were increased significantly as compared to thecontrols. However, erythrocyte SOD, GPX activities and TAC level were reduced significantly in patients (non-diabetic) (P
    Conclusion
    The association between oxidative stress parameters, antioxidant markers, theinflammation index and lipid status parameters suggest their involvement in atherosclerosis development that may lead to CAD progression.
    Keywords: Total antioxidant, Oxidative stress, Inflammation, Non-diabetic, Coronary Artery Disease
  • Samad Golzari, Hassan Soleimanpour*, Payam Raoufi, Shaker Salarilak, Majid Sabahi, Hamidreza Nouri, Yaghoub Heshmat Pages 36-41
    Introduction
    Emergency Severity Index Version 4 (ESI v.4) is a validated triage tool for emergency departments, with an easy training system optimizing the allocation of limitedresources to emergency patients. The present study aimed to determine the outcomes of triagewith ESI v.4 method in all five levels of patients triage in emergency departments.
    Methods
    In this retrospective observational-descriptive study, following the training coursesand implementation of triage with ESI v.4 method, the third quarter of 2008 was randomly selected for study. In this period, all patient files with their codes ending in zero were selectedequaling one-tenth of all files. Triage levels and outcomes were extracted and the obtaineddata from 1309 were expressed using descriptive statistics.
    Results
    The mean age of the patients was 40.73 ± 21.37 years and 59.4% of the subjects weremales. Classification of patients by ESI v.4 level was as the following: 1 (4.0%), 2 (11.6%), 3 (52.8%), 4 (25.5%) and 5 (6.1%). Hospitalization rate by ESI v.4 level was as below: 1(80.76%), 2 (23.68%), 3 (25.75%), 4 (11.76%) and 5 (14.5%).
    Conclusion
    The rate of hospitalization decreased from ESI level 1 to ESI level 5. Althoughthe findings of this study were in line with the previous reports, some discrepancies indicated the existing inaccuracy in out-patient hospitalization system in the evening and night shiftsand also at stage 5 triage level.
    Keywords: Emergency Department, Triage, Emergency Severity Index Version 4
  • Ayyoub Malek, Shahrokh Amiri*, Salman Abdi Pages 42-46
    Introduction
    The etiology of Attention deficit hyperactivity disorder (ADHD) is complex and most likely includes genetic and environmental factors. This study was conducted to evaluatethe role of previous medical history of diseases in ADHD children and their parents during theearlier years of the ADHD children's lives.
    Methods
    In this case-control study, 164 ADHD children attending to Child and AdolescentPsychiatric Clinics of Tabriz University of Medical Sciences, Iran, compared with 166 normal children selected in a random-cluster method from primary and guidance schools. ADHDrating scale (Parents version) and clinical interview based on schedule for Schedule forAffective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version(K-SADS) were used to diagnose ADHD cases and to select the control group. Two groupswere compared for the existence of previous medical history of diseases in children andparents. Fisher's exact test and logistic regression model were used for data analysis.
    Results
    The frequency of maternal history of medical disorders (28.7% vs. 12.0%; P = 0.001)was significantly higher in children with ADHD compared with the control group. The frequency of jaundice, dysentery, epilepsy, asthma, allergy, and head trauma in the medicalhistory of children were not significantly differed between the two groups.
    Conclusion
    According to this preliminary study, it may be concluded that the maternal historyof medical disorders is one of contributing risk factors for ADHD.
    Keywords: Attention Deficit Hyperactivity Disorder, previous medical history of diseases, Parents, Children