مجله دانشکده علوم پزشکی نیشابور
پیاپی 15 (تابستان 1396)

Introduction Breast cancer is one of the most common cancers among women and is spreading with the highest rate in developing countries. The aim of this study was to evaluate serum levels of D-dimer in patients with breast cancer.
In this cross-sectional study, 100 the patients with the diagnosis of breast cancer who have been admitted at Imam Sajjad Hospital for further treatment were enrolled.
Results The average serum D-dimer in stage IV was 628±304, in stage III was 229±101 and in stage II was 180±29. In addition, the frequency of abnormal D-dimer was higher in patients at stage IV. The D-dimer level and the frequency of abnormal D-dimer level were higher in patients with lymph node involvement. Moreover, patients who had abnormal CEA and CA15-3 tumor markers had higher D-dimer level. We have also found serum D-dimer levels in patients 41-50 years old group was higher than other groups.
Conclusion In general, increase in serum D-dimer levels are associated with advanced disease stage, lymph node involvement, and worse prognosis and since the D-dimer is a safe, inexpensive, and available marker can be used to assess prognosis of disease and survival of the patients

Introduction and Aims The aim of the present study was the evaluation of mindfulness-based cognitive therapy efficacy on self-compassion of patients with mixed anxiety-depression disorder.
Materials and Methods Three participants with mixed anxiety-depression disorder were selected by available sampling. Participants evaluated 9 times by Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI-II) and Neff self-compassion Scale (SCS). For data analysis, we employed procedure index, Cohen’ rate of variability, interpretation of ups and downs in the graphs. In the hand to determine the clinical significant percent recovery and effect sizes were recruited.
MBCT significantly increased self-compassion in patients who received MBCT and also controlled their anxiety, depressive signs and symptoms in their follow-up (60 days).
MBCT can imply high efficacy in terms of self-compassion and it can decrease depression and anxiety of participants.

IntroductionGiardia lamblia is one of the most prevalent flagellate protozoa in human with the world-wide distribution. Millions of people are affected by Giardiasis annually. Today, many treatments are available for giardiasis that associated with some side effects. This study is aimed to evaluate the antigiardial activity of Lavandula angustifolia in vivo.
Materials and Methods In this study 25 mice are categorized in 5 groups include; Control group (without any treatment), Positive control (treatment by Metronidazole) and other three groups (treatment by 100, 200 and 400 mg/ml of Plant extracts). Then, after 10 days, the effects of each group are evaluated on the Giardia lamblia. The statistical methods used were based on one-way variance analysis and paired t-comparison that were used in the usual way for normal values in the Bootstrap method for values that were not distributed normalized according to the low sample size.
Results In this study, the body weights of treated mice with different extracts were more than the positive control and less than the negative control. Also, the live cysts were decreased 77.7, 83.4 and 95.1% by the use of 100, 200 and 400 mg/ml of plant extracts.
Conclusion The results of the current study indicated that Lavandula angustifolia has conceivable effects in vivo and it will be a suitable alternative for treatment of Giardiasis.

Introduction and Aims: One of the important strategies to control cutaneous leishmaniasis is preventive behaviors and evaluation of preventive behaviors from leishmaniasis and detecting factors associated with the disorder is the first step in planning for training intervention. Since there is no standard questionnaire in this regard, this study aimed to design and psychometric native tools to evaluate the preventive behaviors of cutaneous leishmaniasis based on BASNEF Model in students of Neyshabur.
In this sectional study, we designed a primary tool after investigated the scientific sources and Needs assessment beliefs Based on BASNEF Model on 25 people from the study population. For psychometric tools, we used artificial validity with the participation of 20 students and content validity (By measuring the ratio of the content validity and content validity index) through an expert panel with the participation of 10 health education experts and tool designed experts. Construct validity (using confirmatory factor analysis) was performed in LISREL software by selecting 226 high school students by using a multistage random sampling method. To determine the reliability of the tool, we used internal consistency and test-retest method.
The basic questionnaire version was designed with 46 items then some items were modified by artificial and content validity.in artificial validity, 2 items were excluded because of having an impact score less than 1.5 and content validity by taking a cut-off point./79 to measure content validity index and cut-off point./62 for the credit test, the number of 8 items to be removed and items Number declined to 36 in artificial and content validity rate. In constructing validity, AGFI = 0.90, RMSEA = 0.040 were obtained by Confirmatory Factor Analysis, Respectively. The reliability of the tool was approved through internal consistency (0/864 = α) and retest test (0/993 =ICC)
The results showed that prevention behavior questionnaire of skin, cutaneous Based on BASNEF Model is valid and reliable with 36 items, and because of the strength of suitable factor structure and psychometric properties, researchers can use it in the related studies.

One of these anomalies that have a high prevalence is higher scoliosis. Higher scoliosis causes problems such as reduction in quality of life, disability, pain, appearance deformities, and in cases, respiratory problems, and increase in scoliosis angle in adulthood. The objective of the study was to examine the effects of 8 weeks of stretching, strength and central stability exercises of female students aged 9 to 13 years.
this study was among the intervention and quasi-experimental studies and population of study included female students aged 9 to 13 years with scoliosis deformity, in which 60 female students who had dorsal scoliosis deformity were selected purposefully and they were randomly assigned to 3 groups (each group containing 20 students) (two experimental groups, the first group includes stretching exercises, second group includes strength and stretching and central stability exercises and one control group).
Exercises program included 8 weeks, 3 sessions per week, and each session lasted 25 to 40 minutes. The measurement of dorsal scoliosis was conducted using plaid plate and photogrammetry.
the results of post-test scores of scoliosis angle showed that corrective exercises program created significant difference among three groups so that, it caused significant reduction in scoliosis angle of subjects of both experimental groups compared to control group. It reduced more in the subjects of the second experimental group (stretching, strength and central stability exercises) compared to subjects of the first experimental group (stretching and strength exercises), while this difference was not significant.
It seems that corrective eight-week exercise program with the emphasis on compound exercises (central stability) as a non-invasive method can have the desired effect in the treatment of scoliosis in students.

Introduction The appetite regulatory role of glycine as a neurotransmitter and neuromodulator has been demonstrated. The present study was aimed to investigate the interaction between glycine and beta-adrenergic receptors in regulating food intake in rats.
Materials and Methods Forty male Wistar rats that weighed 250-300 g were used in this study. The present study was carried out in four periods. The interval between each period was three days. Rats received i.p. injections of various combinations of isoproterenol, glycine, and postsynaptic glycine receptor antagonist (strychnine hydrochloride). Food consumption was recorded 60,120 and 180 min after injection.
Results Intraperitoneal injection of glycine 100,200 and 400 mg/kg BW significantly increased food consumption in all injection times (PConclusion The appetizing effect glycine in the rats is possibly independent from the peripheral beta-adrenergic receptors.

Introduction Polyphenols and physical activity are known as two effective factors on testosterone, Insulin-like growth factor-1(IGF-1) and cortisol hormones level. The aim of the present study was to evaluate the effect of combined training and green coffee consumption on the serum level of testosterone, IGF-1 and cortisol hormone in overweight and obese women.
Materials and Methods 30 volunteer overweight and obese women were randomly divided into three combine training, green coffee and combine training- green coffee groups. Training was conducted four times per week for six weeks. The amount of green coffee consumption was 250 mg per day for 6-weeks. The serum levels of testosterone, IGF-1 and cortisol were measured 24 h before and 48 h after the interventions.
Results The results showed no significant improvement in testosterone and cortisol serum levels in all three combine training, green coffee and the combined training-green coffee groups (p> 0.05). The IGF-1 concentrations significantly increased in the combined training group (p=0.01) and significantly decreased in the green coffee group (p=0.03) but did not change significantly in the combine training- green coffee group (p> 0.05).
Conclusion In consolation, results showed that combine training could be effective in improving IGF-1. However, green coffee and the combined training have not been effective for improving testosterone and cortisol levels. More studies are needed to confirm the findings of this study.

Introduction The alterations and imbalances in homeostasis are one of the main causes of heart attack. Th8ere is a discrepancy about the effects of various types of exercise, exercises, especially resistance exercises on coagulation factors. The objective of this study was to examine the effect of 8 weeks single joint and multiple joint resistance training on some coagulation and blood factors of active young men.
Materials and Methods 30 subjects (20-26 years) were selected with randomly distributed in control group (n=10), single joint resistance training (n=10), and multi-joint resistance training (n=10). The experimental groups performed protocols for 8 weeks, three sessions each week. The Shapiro-Wilk test was used to determine the normality of the data and the differences were compared using the Ancova test and if significant results were reached, Bonferroni test was used.
Results The single joint and multi-joint resistance training group had a significant effect on platelet (PConclusion The 8 weeks of resistance training reduces the number of platelets and also decreases hematocrit and reduces the blood sedimentation, which indicates a reduction in the risk of cardiovascular attacks while exercising.