مجله دانشگاه علوم پزشکی بابل
سال بیستم شماره 5 (پیاپی 128، اردیبهشت 1397)

Delay in recovery of episiotomy can lead to infection and persistence of perineal pain. Perineal pain is a stressful problem for primiparous women and has a negative effect on their function.The present study was conducted to determine the effect of Green tea ointment on the healing process of episiotomy.
This three-blind clinical trial was conducted on 60 primiparous participated in this research, were divided in two groups: Green tea ointment and placebo ointment. According to the routine of the hospital, 500 mg capsule cephalexin was given to all mothers every six hours for seven days. Mothers used an ointments every 12 hours for a period of ten days in the area of sutures. Wound healing was measured on the fifth and tenth day after delivery using REEDA scale.
FINDINGS: There was no significant difference in demographic features and obstetric variables (for example age and weight newborn). Before the intervention, two groups did not have a significant difference in score of the perineal evaluation scale (p=0.475). The average of this scale on the fifth day in the green tea group was (1.83±1.147) and in placebo group it was (3.33±1.155) on the 10th day, the average of the perineal evaluation scale was (1.2±0.805) for the green tea group and (2.63±1.066) for the placebo group. The average of REEDA scores on the 5th and 10th day after delivery was significantly different between the two groups(p Green tea can improve episiotomy wound healing, due to its healing properties.

Reduction of the antioxidant capacity and oxidative damage has a crucial role in development of damage after spinal cord injury. Since pioglitazone (PPAR-gamma agonist) have a powerful antioxidant property, the present study aimed to evaluate the effect of pioglitazone on antioxidant capacity and oxidative damage in the injured areas of spinal cord in rat.
In the present experimental study eighteen male Wistar rats divided into three groups as follow (n=6); sham, control injured and pioglitazone-treated injured group. Spinal cord injury was performed according to the Ping-Weight Drop (contusion) model in rat. The animals received pioglitazone (3 mg/kg) intraperitoneally at times of 15 min after injury and then each 12 hours until a week. At the end, malondialdehyde level, activity of catalase and superoxide dismutase (SOD) enzymes and also histopathological alterations of spinal cord were assessed.
FINDINGS: Induction of spinal cord injury in control injured animals significantly increased the malondialdehyde levels (56%) and decreased the activity of catalase (48%) and SOD (65%) enzymes compared to sham group (P=0.004, P=0.001 and P=0.008, respectively). Pioglitazone in treated injured group significantly decreased the malondialdehyde levels (38%) and increased the activity of catalase (34%) enzyme compared to control injured group (P=0.038 and P=0.014, respectively). Also, pioglitazone prevented the histopathological changes of injured areas in spinal cord.
The findings of present study indicate that treatment with pioglitazone through potentiation of the antioxidant defense capacity of injured spinal cord decreases oxidative damage and also histopathological changes of spinal cord.

Chronic disease is one of the major causes of disability in doing daily activities. The aim of this study is to determine the relationship between chronic disease and disability in daily activities and instrumental activities of daily living in the elderly.
This cross-sectional study was conducted among the elderly of Amirkola. Demographic characteristics (age, gender, level of education and occupation), daily activities and instrumental activities of daily living were collected using a questionnaire. The ability to perform daily activities and instrumental activities was categorized as independently, with the help of others and completely dependent, and ultimately, completely dependent people and those using the help of others were placed in the disability group. The presence of chronic diseases in the elderly was characterized and examined by reviewing the medical records.
FINDINGS: Of 1,500 elderly who were eligible to enter the study, 832 people (55.5%) were male and 668 people (44.5%) were female. In this study, 38 people (2.5%) had a disability in daily activities and 723 (48.2%) had disability in instrumental activities of daily living. The number of associated diseases (p According to the results of this study, the presence of chronic diseases, especially cognitive impairment, is one of the effective factors in disability in daily activities and instrumental activities of daily living.

Coronary artery restenosis following angioplasty may lead to major unwanted cardiac events. This is one of the most important concerns of cardiologists. This study was performed to evaluate the predictors of coronary artery restenosis in patients undergoing angioplasty.
In this cohort study, all 2159 patients who referred to Madani Hospital in Khorramabad, Iran for angioplasty between 2004 and 2015 were followed up regarding the incidence of coronary artery restenosis for one or two years (at least 50% stenosis in the place of the previous angioplasty) depending on the type of stent, and clinical variables related to the lesion and procedure were recorded in an information form. Then, agents for predicting coronary artery restenosis were identified based on CART (Classification and Regression Tree).
FINDINGS: Cumulative incidence of coronary artery restenosis was 12.9% (279 patients) in subcategories: non-drug-eluting stent (25.8%, 114 patients), comorbidity of diabetes and hyperlipidemia (under the subcategory of drug-eluting stents, 19%, 32 patients), multiple drug-eluting stents (under the subcategory of non-diabetic patients, 14.6%, 25 patients), comorbidity of hyperlipidemia and drug abuse (under the subcategory of non-diabetic group who use one drug-eluting stent, 12.8%, 16 patients).
According to the results of this study, stent type, history of diabetes, number of stents, hyperlipidemia and drug abuse are among the most important predictors of coronary artery restenosis.

Health promoting lifestyle is any kind of action that is taken to maintain the health of the individual. Healthy lifestyle plays an important role in improving the maternal-fetal outcomes. The aim of this study is to determine the effect of training pregnant women and their husbands on health promoting lifestyle.
This clinical trial was conducted among 189 pregnant women in the city of Bukan, Iran. Participants were categorized into three groups: the recipients of the training along with their husbands (the first intervention group), the recipients of the training without their husbands (the second group of intervention) and the routine care recipients (control group). Four sessions of group training were held for mothers of both interventional groups and one group training session was held for the mothers of the first intervention group regarding sleep health, nutrition, physical activity, self-image and sexual issues. Health promoting lifestyle questionnaire (score range: 52 - 208) was completed and assessed before the intervention, eight weeks after the intervention and six weeks after delivery.
FINDINGS: There was no statistically significant difference between the groups before the intervention in terms of the total score of health promoting lifestyle. Eight weeks after the intervention, the mean score of health promoting lifestyle was 162.2±2.5 in the first group, 153.6±2.5 in the second group and 133.4±2.4 in the control group, which was significantly higher in both intervention groups compared to the control group (p The results of the study showed that training pregnant women along with their husbands or training the women alone improves lifestyle. However, training pregnant women along with their husbands proved to be more effective than training the women alone.

Resistance to chemotherapy drugs is one of the most important treatment problems in patients with acute lymphoblastic leukemia. Apoptin due to its ability to induce apoptosis in tumor cells, has an undeniable potential in cancer treatment, especially those that respond lessly to chemotherapy. Therefore, in this study, the effect of induction of apoptin expression on induction of cell death in reh malignant lymphoblasts was investigated.
In this experimental study, after culturing of Reh cells (prepared by the Pasteur Institute), the entry of lentiviral vector, metabolic activity and cell proliferation were measured using flow cytometry, MTT and trypan blue at 24, 48, 72 and 96 hours. Real time PCR was also used to determine the apoptin gene expression.
FINDINGS: The results of this study indicate the design and construction of a suitable lentiviral vector that can infect more than 65% of the cells. Also, after infecting the cells with the vector, the apoptin gene expression rate was increased about 10 times to control, and subsequently, the cell viability decreased by 53% time-dependently (p The results of the study showed that apoptin gene expression has anti-tumor activity in Reh cells and can be used as a promising therapy in ALL.

Background. One of the mental issues regarding reproductive performance of women is premenstrual syndrome and hormonal factors are effective on dermatophyte, so that atopic dermatitis is more common in adult women. Thus the aim of this study was to determine the association between premenstrual syndrome and atopic dermatitis.
Methods. This case-control study was carried out on 82 women of reproductive age in 1395. The cases were women with atopic dermatitis and the control group had healthy atopic dermatitis. For each case, one control entered the study. After the selection of cases and controls, demographic questionnaire and Premenstrual Symptoms Screening test (PSST) were completed by both groups. The minimum score of PSST was zero and the maximum was 42. A significant level of 0.05 was considered.
Findings. The mean age of subjects in the case group was 17.17 ± 4.45 and in the control group was 27.29 ± 8.03 years. The results showed by controlling the possible confounding factors as age, occupation and marital status the probability of having moderate or severe premenstrual syndrome in patients with atopic dermatitis is 13.26 (OR= 13.26, 95% CI: 3.31, 53.07), as compared with healthy subjects.
Conclusion. The results showed that there is a strong relationship between moderate to severe menstrual syndrome and atopic dermatitis in women.

Since choosing mode of delivery is one of the most important choices in a woman's life, the factors affecting this choice are necessary to be considered. In recent years, the effect of various psychological factors on attitude towards delivery has been considered. One of these factors is the mother's perceived stress. Therefore, this study was conducted to determine the relationship between perceived stress and attitude towards delivery and choosing mode of delivery among pregnant women.
This prospective cohort study was conducted among 305 pregnant women who were at week 32 of their pregnancy or above who referred to selected health centers of Ahvaz in 2016. "Demographic information", "Perceived stress" and "Attitude towards mode of delivery" were collected using a questionnaire. Perceived stress score was from zero to 56 (higher score indicates higher perceived stress), and attitude towards delivery score was from 68 to 204 (higher score indicates more positive attitude towards delivery).
FINDINGS: The mean perceived stress score in subjects with positive, neutral and negative attitudes toward delivery were 27.08±10.86, 25.70±8.82 and 22.36±15.14, respectively, and in women with virginal and cesarean deliveries were 26.45±10.18 and 25.24±10.44, respectively. There was no significant correlation between perceived stress and attitude towards delivery (p=0.22) and choosing mode of delivery (p=0.49).
The results of the study showed that there is no relationship between perceived stress and attitude towards delivery and choosing mode of delivery.

Postoperative infection has been one of the most frequent problems in orthopedics. The aim of this study was investigating type and amount of prophylactic antibiotics used in the orthopedic cases administered in Shahid Beheshti Hospital in Babol, northern Iran. Reporting these results can be helpful for better planning for control and management programs of health and treatment.
This cross-sectional study was conducted on 450 traumatic and non-traumatic patients underwent elective orthopedic surgeries and received antibiotic prophylaxis during 2015-2016. The necessary data were collected from the patient's records using a predesigned checklist. This checklist consisted of demographic information, type and mechanism of trauma and information related to prophylaxis (name of antibiotic, dosage, administration method, time to start prophylaxis, administration intervals and overall prophylaxis duration).
Out of 450 patients, 300 (66.7%) were male and others were female. The mean age was 42.37±21.53. The most commonly used antibiotic was cefazolin (n=437, 97.3%) and gentamycin (n=276, 62%), and the lowest was amikacin (n=8, 1.8%). Mean duration of use was 4.92±1.8 days, ranging from 1 to 15 days.
The results showed that the use of prophylactic antibiotics is high and they should be administered with more precise control. The most commonly used antibiotic for prophylaxis was cefazolin and the least was amikacin.

Breast cancer is one of the most common cancers in women. One of the new methods of therapy are the use of tumor markers (ER, PR, Ki67, Her2). This study aimed to investigate the prognostic factors that affecting the survival of women with breast cancer in Yazd using parametric and Cox model as well as comparing the effectiveness of these models.
The 538 of the patients referred to Ramezanzade Radiotherapy Center who had breast cancer and recorded survival status as a census from the April 2005 until March 2012. The criterion to compare the performance of models was Akaike information criterion. Data was then analyzed in R software and 0.05 was considered as the significance level.
Findings: according to the Kaplan Meier method, Average of 1,2,3,5 and 8-years survival rate, and estimated, respectively, 0.976, 0.941, 0.898, 0.823 and 0.737. mean age of women with breast cancer was 48.03 ± 11.66 years and mean of survival time was 97.4±64.23. Ki67 variables for patients under 40 years of age (HR = 1.374, CI: 95% = [1.023, 3.536], and Her2 for patients aged 40 years and over (HR = 2.567, CI: 95% = [1.1767.5.598]) is significant on survival time.
Ki67 and Her2 variables had a positive effect on death risk.According to Akaike
information criterion we found that Cox model best fits for determining Prognostic factors influencing the diagnosis of retinopathy.