فهرست مطالب

Kerman University of Medical Sciences - Volume:25 Issue: 3, 2018
  • Volume:25 Issue: 3, 2018
  • تاریخ انتشار: 1397/03/08
  • تعداد عناوین: 10
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  • Hoda Bazafkan, Seyed, morteza Javadirad , Manoochehr Tavasoli, Simin Hemati Pages 191-197
    Background
    Prostate cancer is increasing among Iranian men and gene polymorphisms may play a role in the development of prostate cancer. Insulin-like growth factor 1 (IGF1) gene polymorphisms have been deeply explored in different malignancies. In this study, we aimed to explore the association of IGF1 CA repeat length polymorphism with the risk of prostate cancer development in Isfahan province of Iran.
    Method
    The total blood of 100 prostate cancer patients and the equivalent matched control individuals were collected. DNA extraction was followed by IGF1 promoter polymorphism amplification. Genotyping was performed using polyacrylamide gel electrophoresis and sequencing was performed.
    Results
    According to the results, IGF1 promoter polymorphic site showed six different alleles ranging from 17-22 CA repeats among our studied population. Comparing SL heterozygotes with both homozygotes, a significant increase in RR value (RR=4.5, p=0.031) was observed. Although age adjustment and family history did not elevate the RR value, but a significantly elevated risk of prostate cancer (RR= 3.143, p=0.002) was shown when we compared SS patients with LL ones according to their BPH history.
    Conclusion
    In conclusion, carriers of (CA)17 allele could be at a higher risk of prostate cancer development and being SL heterozygotes could increase the risk of BPH development in our studied population
    Keywords: Prostate cancer, Insulin-like growth factor 1, Polymorphism
  • Mohammad Ail Damghani, Mohammad Ali Haghbin, Elham Karbasi Pages 198-205
    Background
    This study aimed to investigate the analgesic effects of ketamine, ketorolac and dexamethasone after adenotonsillectomy surgery in children aged 4 to 18 years.
    Methods
    This clinical trial was undertaken on children aged 4 to 18 years who were admitted in Shafa Hospital of Kerman for tonsillectomy and adenotonsillectomy surgeries. Simple randomization was used for sampling and the subjects were randomly divided into three groups. In all three groups, 1-8 mg dexamethasone was administered/ injected. 0.5 mg/kg ketamine, 0.5 mg/kg ketorolac and dexamethasone were administered/ injected in the first, second and third (control) group groups respectively. This means that subjects in the control group did not receive any drug except dexamethasone. The Wong-Baker Faces Pain Rating Scale was used for measuring the level of pain. Statistical analysis was performed using SPSS software, version 21.
    Results
    According to the post-operative pain of patients who used ketamine, ketorolac and dexamethasone during the recovery time, there was a significant difference in six hours after surgery and the time of discharge/release as the highest pain score was related to the control group (the group that only used dexamethasone). Moreover, the pain score of the subjects or the patients who received ketamine at the time of discharge was significantly higher (p<0.05) than the ones who received ketorolac.
    Conclusion
    Administration of ketamine and ketorolac can be beneficial for controlling and decreasing the post-operative pain in patients undergoing adenotonsillectomy surgery
    Keywords: Ketamine, Ketorolac, Dexamethasone, Adenotonsillectomy Surgery
  • Parviz Amini, Molook Torabi, Parizi, Ali Taheri, Shahrzad Taheri Pages 206-212
    Background
    Resin cements are widely used for cementation of FRC posts, but their bond strength can be influenced by cement type and cementation technique. The aim of this study was to determine the effect of type of resin cement and cementation technique on the bond strength of fiber posts.
    Methods
    Forty five extracted mandibular premolars with a minimum root length of 14 mm were cut from 1 mm above the CEJ and root canal therapy was performed on them. Based on the type of cement, they were randomly divided into three groups: 1- Permacem, 2- Totalcem and 3- Breeze. Each group was divided into three subgroups based on cementation technique: 1- paper point, 2- lentulo and 3- tip. The push out test was carried out on 2-mm sections of cervical, medial and apical areas in the universal testing machine with a speed of 1 mm/min.
    Results
    The highest mean of bond strength among cements was in Breeze cement, but this finding was not statistically significant. In terms of different cementation techniques, the highest strength was found for lentulo technique. The bond strength showed no significant difference at different sections of root based on the type of cement and cementation technique.
    Conclusion
    Cement type has no significant effect on bond strength. The use of lentulo enhances bond strength significantly. No difference was observed in bond strength of different sections of the root in different cements. The greatest fracture mode was adhesive fracture between post and cement
    Keywords: Resin cement, Fiber post, Cementation technique, Bond strength
  • Khalil Eskandari , Bahador Karami, Yaghoub Pourshojaei , Zahra Lori, Gooini, Elham Soltanipour, Joneghani, Mohammad, Taghi Moradi, Ali Asadipour Pages 213-227
    Background
    An efficient, promoted tri-component catalytic reaction between barbituric acid (or N,N-dimethyl barbituric acid), 4-hydroxy coumarin, and a wide range of aryl aldehydes using zinc oxide nanowires (ZnO NWs) to obtain some new 4-hydroxychromenylarylmethyl-6-hydroxypyrimidine-2,4-diones is described.
    Method
    The reactants were successfully condensed via three C-C bond formation by zinc oxide nanowires (ZnO NWs) as an efficient, environmentally safe and recyclable nano catalyst to produce target molecules. In addition, the biological effects of synthesized products by the use of DPPH and acyclovir as positive controls and also Hep-2, vero cell, HSV-1, and adenovirus as four applied cell lines have been evaluated.
    Results
    The results showed that synthesized products have anti-oxidant, cytotoxic and anti-viral activities and can offer promising prospect as biologically active agents.
    Conclusion
    This achievement in an efficient and eco-friendly synthesis of novel analogous of hybrid molecules in aqueous media with special biological properties may engross chemists and pharmacologists as well as pharmacists in future
    Keywords: Synthesis, Ultrasound assisted, Bio-assay, Anti-oxidant, Cytotoxic, Anti-viral, Nano-catalyst
  • Nasser Pouladi , Mohammad, Ali HosseinpourFeizi, Shideh Montasser Kouhsari, Davoud Farajzadeh, Hourieh Khani, Reyhaneh Ravanbakhsh Gavgani, Narges Dastmalch, Yalda Arghavanian Pages 228-242
    Background
    This study was done in order to enhance our understanding about molecular and epidemiological features of breast cancer among the Azeri population with special emphasis on the detection of TP53 mutations. We also analyzed the role of the P53codon72 polymorphism (rs1042522) and its role in susceptibility to breast cancer.
    Methods
    Tumor and control samples were collected from 248 patients and 189 controls. TP53 mutations in exons4-9 and adjacent intronic regions were detected by direct sequencing in 130 of these tumor samples. Allele-specific PCR amplification (ARMS-PCR) was used to detect polymorphisms at P53codon72 in 248 patients and 189 controls. Data were analyzed using χ2 test or Fisher's exact and a p value of <0.05 was considered significant.
    Results
    We identified alterations in 17.69% of the exonic and intronic regions within the TP53. We detected 23 mutant and 107 non-mutant samples. These mutations comprised 21 single-base substitutions (15-transitions and 6-transversions), one deletion and one complex. Exon6 was identified as a highly mutable region, with ten out of all 23 (43.47%) observed mutations. We did not observe a significant association between polymorphism and mutation status (p>0.05). Also, the results did not show a significant correlation between P53 mutational status and clinicopathological features. Distribution differences in the P53codon72 polymorphism between the cases and controls were not statistically significant (p>0.05).
    Conclusion
    It might be concluded that P53 mutational status and codon72 polymorphism could not be considered as biomarker for breast cancer risk and its clinical features in the studied population. However, further investigations are needed to support these findings
    Keywords: Breast cancer, P53, Codon72, Mutation, Azeri population
  • Mosayyeb Mobasheri, Manijeh Mokhtari , Tayebeh Toliyat, Masoud Mehrpour Pages 243-254
    Background
    Echogenic liposomes (ELIPs) encapsulate drugs and gas bubbles within lipid vesicles. The destruction of ELIPs in response to MHz and kHz ultrasound waves has been studied previously. Applying ultrasound above a certain threshold causes encapsulated gas bubbles destruct rapidly by fragmentation or more slowly by acoustically driven diffusion. This study compares the destruction of recombinant tissue plasminogen activator (rtPA) -loaded echogenic liposomes using three frequency protocols: 130 kHz, 1 MHz and dual (130 kHz + 1 MHz).
    Method
    In gel phantom, ELIPs were imaged by diagnostic ultrasound system and simultaneously destructive ultrasonic fields were applied at different intensities in each protocol. Images were analyzed.
    Results
    According to the results, 80% decline in MGV (mean of gray value) relative to initial MGV was associated with ELIPs fragmentation. At 130 kHz, results showed an 80% decline in MGV and fragmentation happened at all applied ultrasound intensities (0.01 W/cm2 as fragmentation threshold). In MHz and dual protocols, on average, less than 50% decline in MGV was observed which indicated an acoustically driven diffusion.
    Conclusion
    Our study shows that kHz protocol fragments ELIPs more effectively than other two protocols. For better results, dual frequency protocols need optimized combination of frequencies and phases
    Keywords: Echogenic liposomes, Destruction, Fragmentation, Acoustically driven diffusion
  • Ali Jomehzadeh, Mohammad Hasan Larizadeh , Zahra Jomehzadeh Pages 255-264
    Background
    Breast cancer is becoming more frequently diagnosed at early stages with improved long term outcomes. Radiation-related heart disease and lung cancer can occur following radiotherapy for breast cancer. The aim of this study was to evaluate some dosimetric parameters of heart and lung during whole breast radiotherapy.
    Methods
    Twenty five consecutive patients with breast cancer who underwent radiotherapy were included in this study. Plans that employed the 3D conventional radiotherapy technique (Tangential Technique) were generated for each patient. Dose-volume histograms (DVHs) were calculated and dosimetric parameters such as, mean dose/volume receiving a dose 30 Gy (V30), mean dose/ volume receiving a dose 20 Gy (V20) for heart and lung were assessed, respectively.
    Results
    The average of mean dose of heart on left and right side irradiation was 9.68±5.10 Gy and 1.23±1.51 Gy, respectively. The average of mean dose of ipsilateral lung on left and right side irradiation was 14.49±4.07 Gy and 11.69±3.37 Gy, respectively. The percentage of heart volume that received at least 30 Gy was 16.32±9.56% for the left-sided treatment. The percentage of lung volume that received at least 20 Gy was 23.47±11.05% and 24.12±7.77% respectively on the left and right-sided breast irradiation.
    Conclusion
    Tangential beam conventional radiotherapy of the chest wall of postmastectomy breast cancer patients provides the potential to significantly keep the DVH parameters of heart and lung as low as the QUANTEC constrains
    Keywords: Radiotherapy, Tangential Breast Technique, Dose-volume Histograms, Heart, Lung
  • Behrouz Davari, Farhad Sarihi, Kamran Akbarzadeh , Mansour Nazari, Amir Hossein Zahirnia, Abbas Aghaei Afshar Pages 265-272
    Background
    Some members of family Calliphoridae are myiasis agents and mechanical vectors of some pathogens. The aim of this study was to measure the biodiversity and synanthropy behaviour of Calliphoridae flies in Abadan, Khuzestan province.
    Methods
    Data were collected based on a monthly schedule during March to December 2014 in urban, semi-urban and rural ecosystems of Abadan County. Bottle trap was equipped with 30 g of chicken liver and installed 3 days in each collection site where net collection was done for about 30 minutes. Synanthropy Index (SI) of flies and biodiversity indices including Simpson, Shannon-Wienner and Margalef were calculated.
    Results
    As many as 1479 samples of Calliphoridae were collected including 18, 1212 and 249 specimens of Chrysomyia megacephala, C. bezziana and C. albiceps respectively. C. bezziana showed a moderate SI in some collecting times. In spite of more collection of C. megacephala in all three ecosystems, its SI had the highest range in comparisons with the others. The biodiversity of Calliphoridae community was high in spring (H´= 0.67) while the highest diversity of dominant species was in autumn (1-D = 0.74). Margalef Index showed equal estimation of species richness in spring and autumn (Mg = 0.3) but it was reduced in summer.
    Conclusion
    C. megacephala was the common species of Calliphoridae in Abadan. Abadan is an old international county in Iran which is the host of many domestic and international engineers, workers and visitors. Knowing the fauna and behaviour of medically important flies would be a major fact for the conditions of the health status of this city
    Keywords: Biodiversity, Synanthropy, Calliphoridae, Abadan
  • shabnam mohammadi , Nasibeh Ghandy Pages 273-277
    Carotid artery is the most important artery that carries the major part of the blood supply to the head and neck. The branching of the common carotid artery usually occurs at the upper edge of the thyroid cartilage. The placement of carotid sinus has also increased its importance in this area. Considering the clinical importance of knowledge about carotid artery variations, this case is reported.
    During the routine dissection of a 55-year-old man, a unilateral variation of right common carotid artery was found in the dissection saloon of School of Medicine. This artery was divided into two branches at the inferior border of the thyroid cartilage. The left common carotid artery was branched at the superior border of the thyroid cartilage.
    Knowledge of carotid artery variations is necessary for anatomists, neurosurgeons, in neck, ENT, and jaw surgeries as well as for angiography, catheterization and carotid arterectomy
    Keywords: Carotid artery, Cadaver, Variation, Human, Bifurcation
  • Sajad Azimi Mehrabadi, Mohsen Yavari, Alireza Asgari Golzardi, Mohsen Ebrahimi, Monfared, Mostafa Alizadeh, Saeed Changizi, Ashtiyani Pages 278-286
    Background
    Headache is a common clinical symptom which goes far back in human history. This study is a quick review on headache concerning its diagnosis and treatment based on writings of Rhazes and Avicenna as the most distinguished and prominent scholars in Iranian medical history.
    Methods
    In this review the reliable literature on related traditional medicine was investigated. The sources include: Al-Hawi Fi Al-Tibb (Liber the Continens), Mansuri fi al-tahb, the treasure of Khwarazm shah, The Canon of Medicine, Kamil al-Sanate al-Tebie as well as related articles retrieved from different databases.
    These databases included Scopus, Medline, PubMed, science Direct, SID, and Google Scholar. In addition, other original texts and sources of Neurology were perused and relevant information was abstracted. In this regard, the diseases of the head, Suda (headache), and the subset of the disease, the term of Shaqeeqa (migraine), were searched in original books of Persian medicine.
    Results
    Diagnosis of temperament, diet modification, use of medicinal herbs and treatments such as massage, bloodletting, dry cupping and purgation of the body from various additional materials were considered as important components of the treatment protocol.
    Conclusion
    The differential diagnosis of migraine from other types of headaches, as well as providing a unique and specific theory for the cause of migraine in the works of Rhazes and Avicenna is surprising. Also, the use of multiple therapies in the treatment of migraine and the selection of herbs with sedative, anti-inflammatory and dermal compositions make it necessary to reconsider and study the experiences of traditional medicine practitioners again
    Keywords: Migraine, Traditional medicine, Headache, Shaqeeqa, Rhazes, Avicenna