فهرست مطالب

  • Volume:6 Issue:1, 2019
  • تاریخ انتشار: 1397/11/01
  • تعداد عناوین: 6
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  • Arumugam AP, Elango Govindan, Guhanathan, Selvam* Pages 1-13
    A selected solid complex of the Schiff base ligand derived from Glutaric anhydride with Cu(II) ion was synthesized and characterized by FT-IR, Electronic, ESR Spectral Analyses, Magnetic susceptibility and Molar Conductance Measurements. The disappearance of ν(O-H) hydroxyl band of the phenolic and the lowering shift of the stretching frequency of the ν(CH=N) azomethine band in the ligand after complexation, indicated the coordination through the phenolic oxygen atom (after deprotonation) and azomethine nitrogen atom respectively of the Schiff base ligand. The lower values of molar conductance indicate the non-electrolytic nature of these complex. The ESR spectrum of the Copper complex has octahedral geometry. The Schiff base ligand and its complex further identified by 1H NMR, 13C NMR, SEM, EDX and molecular docking study.The anticancer potential of the Copper (II) complex was determined against A549 lung cancer cells, they exhibited appreciable anticancer activity. The in vitro cytotoxicity of the complex was examined against cancer cell line by MTT assay.The Schiff base Cu (II) complex was tested its cytotoxicity and found that the 50 percentage of activity inhibitory concentration (IC50) value around 91.25 percentage in 7.8 μg/ml.
    Keywords: Molecular Docking study, ESR Spectral analysis, Anticancer activity, Cytotoxicity, SEM, EDX
  • Mohammad noormohammadi * Pages 14-22
    Generally, the drilling mud is divided into three groups of oil (gas oil) and gas based on its base (the main phase), which is often mixed drilling mud from two or more times a mixture of all three fluids that are present at the same time. In this paper, we first investigate the types of drilling flowers, and then we study the pollution of the types of drilling flowers that are said to be any material (solid, liquid or gas) that has a decisive influence on the physical and chemical properties of the fluid. . The components that cause the pollution of a flower type are not necessarily contaminated in other types of flowers and then provide solutions for the treatment of mud flowers.
    Keywords: Drilling mud, Main phase, Contamination, Components, Treatment
  • Nastaran Parsafard*, Mohammad Hasan Peyrovi, Zahra Mohammadian Pages 23-33
    The kinetics of toluene hydrogenation over Ni-supported catalysts with various supports was investigated under the wide range of conditions as 130 to 210 °C reaction temperature, 2.6×10-5 to 5.9×10-5 atm partial pressure of hydrogen and 1.4×10-9 to 3.7×10-8 atm partial pressure of toluene. For more study, two kinetics models were also selected and studied to describe the kinetics of this process. The modelling study indicates that the competitive adsorption mechanism provides a good fit towards the experimental data and allows to determine the kinetics parameters. According to these studies, Ni/HZSM-5(40 wt. %)-HMS catalyst has better performance than other prepared catalysts for the toluene hydrogenation process.
    Keywords: Toluene, Mechanism, Zeolite, Modelling, Hydrogenation
  • Nosrat Madadi Mahani * Pages 34-42
    Thiazoles derivatives are consisted in chemical compounds such as antimicrobial and anticancer medicine. Since polylactic-co-glycolic acid (PLGA) polymeric nanoparticles has been conversed about nanomedicine applications and particularly as drug delivery systems. Because of molecular self-assemblies and biodegradability of PLGA polymer, it can be used to carry anti-cancer and antimicrobial drugs. The capability of PLGA polymer-based drug delivery system in the treatment of cancer has been studied by quantum MM/QM approach. Theoretical study of the interaction between polylactic-co-glycolic acid polymeric nanoparticles and thiazoline derivatives has been performed by combination of DFT and molecular mechanics approach. The results obtained from this study, displayed that PLGA polymeric nanoparticles has feasible interaction that include hydrogen bond and Vander Waals interaction and showed clearly that these systems have comparatively low permanence and so PLGA polymer is suitable drug delivery that have been studied for anti-cancer drug. Investigation of QM/MM calculations and the interaction energies of the thiazoline derivatives and PLGA polymeric nanoparticles with counterpoise method represent that this carrier can be utilized to modify the biological and anti-cancer activity of thiazoline derivatives
    Keywords: Polylactic-co-Glycolic Acid (PLGA), polymeric nanoparticles, Anti-Cancer Agents, Thiazoline Derivatives, Quantum Mechanics, Molecular Mechanics
  • Amir Faravar *, Mehrdad Manteghian Pages 43-57
    Prediction of the nucleation mechanism is one of the most critical factors in the design of a crystallization system. Information about the nucleation mechanism helps to control the size, shape, size distribution, and purity of the produced crystals. When the crystallization method is used for producing nanoparticles, the nucleation mechanism should be predicted. In this study, an empirical correlation based on the induction time, classical nucleation theory, and Kashchive model is used to determine the nucleation mechanism. Nanoparticles are produced in the presence of Cetyl Trimethyl Ammonium Bromide (CTAB) and the effect of CTAB on the induction time and the interfacial tensions of potassium chloride nanoparticles have been investigated. The obtained results demonstrated that the nucleation mechanism of potassium chloride nanoparticles is heterogeneous. This method is simple and can be applied at ambient conditions for synthesis other mineral nanoparticles. It can also be applied to study the induction time with high accuracy.
    Keywords: Nucleation mechanism, Potassium chloride, nanoparticles, Induction time, Interfacial tension
  • Ahmad Reza Abbasian *, Mohammad Reza Rahimipour, Zohreh Hamnabard Pages 58-65
    Li2TiO3 compound is one of the most important tritium breeding ceramics for industrial application in the nuclear fusion reactor. The use of the hydrothermal method for preparing ceramic composite materials is new trend. In this work, hybrid nanocomposite microspheres of the nanocrystallites Li2TiO3 were prepared at low temperature 400°C. Nanocomposite powders synthesized by the batch supercritical hydrothermal method for 12 hours under pressure 12MPa. The raw materials were used containing tetrabutyl titanate (Ti(C4H9O)4) as a titanium source, lithium nitrate (LiNO3) as a lithium source, citric acid as a chelating agent and nitric acid as pH controller. The samples were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) and X-ray diffraction (XRD). The SEM micrographs showed the synthesized powders have microsphere shape with range size 1 to 3.5 micrometers. XRD result illustrates the microspheres are nanostructure with cubic and monoclinic crystal structures. According to XRD results and using known Scherrer’s equation, the crystallite size of monoclinic phase about 18 nm and monoclinic about 14 nm were determined. The TEM results show that two type of particles morphologies are present in the synthesized microspheres. The first is a spherical shape with a particle size smaller than 100 nm and second is an irregular shape with a particle size between 100 to 200 nm.
    Keywords: Li2TiO3, tritium breeding, microspheres, lithium-ion, hydrothermal synthesis