فهرست مطالب

Advanced Medical Sciences and Applied Technologies - Volume:3 Issue:1, 2019
  • Volume:3 Issue:1, 2019
  • تاریخ انتشار: 1397/11/13
  • تعداد عناوین: 7
  • Sanaz Alaee, Mojtaba Ilani Pages 3-7

    Titanium Dioxide (TiO2) nanoparticle has a wide range of application in industrial and consumer products especially in cosmetics such as high sun protection factor creams in order to protect the skin from UV light. In spite of its increased production and use there is not enough epidemiological data regarding TiO2 nanoparticle toxicity. Toxic effects of TiO 2 nanoparticles on human reproductive systems have been investigated by many studies mostly by employing animal models, but results are extremely conflicted and inconsistent. In this review we summarized published data about the effects of TiO2 nanoparticle on male and female reproductive systems to clarify its possible toxic effects on reproduction and fertility.

  • Alireza Ebrahiminezhad, Zahra Manafi, Aydin Berenjian, Sedigheh Kianpour, Younes Ghasemi Pages 9-15

    Iron Reducing Bacteria (IRB) are one of the most applicable microorganisms in various industrial and environmental activities. These bacteria play a main role in the natural iron transformation. They act in a reverse metabolic pathway in contrast to iron oxidizing bacteria. In the anaerobic conditions IRB are capable to use ferric ion as the final electron acceptor and reduce Fe3+ to Fe2+. What makes these bacteria interesting in bionanotechnology is that IRB are able to synthesize iron nanostructures. In this mini review we have a quick look on the diversity, metabolism, and cultivation of IRB. Finally, we discuss iron nano structures which biosynthesized by IRB.

  • Rowaa Ahmed Mostafa, Mohmmed Mahmoud Al, Sherbeeny, Ibrahim Anwar Abdelazim, Amr Abdelaziz Khalifa, Ahmed Abdelkader Fahmy, Nour El, Din Ahmed Pages 17-20

    This study designed to detect the prevalence of ovarian and/or adrenal hyperandrogenism in women with Polycystic Ovary Syndrome (PCOS).Materials: One hundred PCOS women included in this cross sectional study after informed consent and approval of the study by local institute ethical committee. Diagnosis of PCOS based on the Rotterdam ESHRE criteria. Studied women underwent complete physical examination with calculation of body mass index (BMI) and assessment of hirsutism by modified Ferriman Gallway score. Clotted blood sample taken from studied women for measurement of serum total testosterone, sex hormone binding globulin (SHBG) and dehydroepiandrosterone sulfate (DHEAS) to detect the prevalence of ovarian and/or adrenal hyperandrogenism in PCOS women.


    66% of studied PCOS women presented with hirsutism, 22% of studied PCOS women presented with menstrual irregularities (hypomenorrhea, oligomenorrhea) and dysmenorrhea was the presenting symptom in 12%. Free testosterone was elevated in 50 cases of studied women; DHEAS was elevated in 30 cases of studied women while the remaining 20 cases had elevated both free testosterone and DHEAS. Mean free testosterone was 2.6±1.8 pg/ml and mean DHEAS was 5.5±3.8 mg/l.


    The ovary is the main source of excess androgen in PCOS (50% of studied women) and excess adrenal androgen found in 30% of studied PCOS women, further large studies recommended to confirm this finding.

  • Hany Sabry Ahmed Ibrahim, Sayed Bakry, Ahmad Rashad Elshahed, Ahmed Rammah Pages 21-27

    Freezing and in vitro culture of testicular spermatozoa or tissue are reliable approaches for the management of azoospermic patients and could all for the possibility of multiple IVF-ICSI procedures. However, the effect of cryopreservation duration on pregnancy outcome had been not fully examined. To analyze pregnancy outcome in patients underwent ICSI procedure in relation to duration of cryopreservation of the sperms. Materials: The present study included 62 couples who underwent to 255 cycles of ICSI; during the period from January 2013 to June 2014; in the International Islamic Centre for Population Studies and Researches. Couples of whom, male partner suffered from azoospermia underwent TESE for cryopreservation was included. Thawed testicular spermatozoa were used subsequently for an ICSI cycle. Women included in this study had also received routine infertility work-up. Frozen-thawed embryos were transferred on day 3–5. Clinical and ongoing pregnancy was defined as the presence of a gestational sac by transvaginal ultrasound in the 5th to 7th gestational week and the existence of a fetal heart beat at 12 weeks. Patient characteristics and pregnancy outcomes were documented.


    The duration of cryopreservation had no effect on ICSI outcome, except significant difference between different groups as regard to cleavage rate (the higher cleavage rate was observed in second group, then fourth, fifth, first and third groups (it was 96.74±8.71, 94.50±8.82, 93.50±12.0, 92.35±12.47 and then 89.20±13.69 respectively). In addition, females in different groups were comparable as regard to personal characteristics.


    Duration of cryopreservation had no effect on pregnancy outcome.

  • Azam Dekamin, Ahmad Sheibatolhamdi Pages 29-37

    Coronary artery disease (CAD) is caused by atherosclerosis in coronary arteries and results in cardiac arrest and heart attack. Angiography is one of the most accurate methods to diagnose Heart disease, it incurs high expenses and comes with side effects. Data mining is the extraction of hidden predictive information and unknown data, patterns, relationships and knowledge by exploring the large data sets which are difficult to find and detect with traditional statistical methods. One of the biggest problems that prevent pattern recognition from functioning rapidly and effectively are the noisy and inconsistent data in databases. The present study intends to provide a data preparation method based on clustering algorithms for diagnosis Coronary artery disease with higher efficiency and fewer errors. Materials: In this study, the data under investigation was collected from a number of 303 persons referring to the heart unit in one of Tehran-based hospitals within the time interval 2011 to 2013. It included 54 features. K-means algorithm is used for clustering based data preprocessing system for elimination of noisy and inconsistent data and Naïve Bayes, K nearest neighbor and Decision tree are used for classification. Another two feature subset selection methods for cleaning data are also used to make a comparison between clustering based method and attribute selection method. Rapid Miner Software was adopted to conduct this study.


    Findings of this research indicated that the suggested model will have the highest efficiency, 90.91. According to the results, the proposed method of performance is highly successful compared to other results attained and seems effective for pattern recognition applications.


    With these results, the proposed method can be used in the diagnosis of coronary artery disease

  • Abolfazl Alipour, Mohammadreza Dorvash, Yasaman Yeganeh, Gholamreza Hatam, Seyed Hasan Seradj Pages 39-46

    Learning is a cornerstone of intelligent behavior in animals. This behavior has been mostly studied in organisms with a fairly complex nervous system. However, recent reports of learning in unicellular organisms suggested the existence of associative learning in unicellular organisms. In particular, the capability to associate different light intensities with cathodal stimulation in paramecium is of special interest. We have investigated the previous reports on this phenomenon and proposed a molecular mechanism for learning behavior in paramecium. Specifically, we have used the existing evolutionary evidence in order to find the possible molecular pathways that may play a role in Paramecium’s learning. Moreover, previous studies have been reviewed in order to propose new experiments that can verify the plausibility of the present hypothesis

  • Soheila Ghassamipour, Zahra Fotoohabadi, Nasim Mohammadpour Ghalati, Uranous Niroumand Pages 47-51

    A simple and green synthesis of α-hydroxy phosphonates has been performed by reaction between aldehydes and triethyl phosphite using sodium dodecylphosphonate as anionic surfactant in micellar media under reflux conditions. The novel structures were recognized by 1H NMR, 13C NMR and 31P-NMR. The employ of green media, clean reaction profiles, simple experimental and work up procedures and high yields are some of the unique features of this process.