فهرست مطالب

  • Volume:8 Issue:23, 2019
  • تاریخ انتشار: 1398/05/31
  • تعداد عناوین: 4
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  • WITHDRAWN: Histological and Behavioral Alterations Following hADSCs Intravenous Administration in Alzheimer’s Rat Model
    Milad Kazemiha, Arash Sarveazad, Fatemeh Moradi, Marjan Shariatpanahi, Farnaz Ramezanpour, Mehran Vosoogh, Masoomeh Mohamadpour, Maryam Doshmanziari, Mina Eftekharzadeh * Page 1
  • Kiyanoosh Darash, Mohsen Ghanbarzadeh*, Masoud Nikbakht Page 2
    Background
    Studies have shown that physical activity and the consumption of the medicinal herb saffron affect patientswhohave testicular problems and those who are prone to apoptosis. In this study, the effects of simultaneous eight-week exercise and crocin usage on the oxidation and anti-oxidation indices of male rats’ testicles subjected to apoptosis were investigated.
    Methods
    In this experimental study, 56 Wistar rats were randomly divided into 7 groups. The groups receiving supplement, exercise, and supplement received oral doses of 10 and 50mgper kg of body weight for 8 weeks. The control group received only normal saline and the same amount of supplement as gavage. Fourty-eight hours after the last exercise session and after 10-12 hours of fasting overnight, blood samples were collected from animals after anesthesia and measured by dye-matase and catalase activity and the concentration of malondialdehyde in testicular tissue was measured. Statistical analysis was performed using SPSS software version 20 (P < 0.05).
    Results
    The results showed that in all groups except the sick group through exercise and receiving a dose of 10 and 50 mg per kg crocin, dismutase and catalase indices increase, and the malondialdehyde index decreased and the T4 (doxorubicine + 10mgcrocin) group significantly increased in the antioxidant index and decreased in oxidative index (P < 0.05).
    Conclusions
    The findings of this study showed that endurance training and crocin dose-dependent injections by decreasing the toxicity of doxorubicin reduced the oxidative stress and free radicals and made good compatibility in the antioxidant system of testicular tissue in male rats.
    Keywords: Continuous Exercise, Crocin, Oxidative, Antioxidant Indices, Tests, Apoptosis
  • Ali Naseri, Sadrallah Khosravi, Mansour Fatemi, Mojgan Zolfaghari * Page 3
    Background
    Maternal-fetal attachment (MFA) is the first relationship between a mother and her child, which generally begins during pregnancy. The maternal psychological state affects fetal growth and health. MFA is associated with the mental and psychological condition in pregnant women.
    Objectives
    The aim of this study was the estimation of the variance of MFA, according to the personality traits in pregnancy.
    Methods
    Using a descriptive correlational study design, we studied pregnant women who were more than 24 weeks pregnant and were referring to the obstetric ward of the Kowsar Hospital, Shiraz, Iran, during May to June 2015. The sample size was estimated to be 200 women by Morgan’s table. A total of 29 participants were removed due to incomplete questionnaires, and 171 participants were selected. Data collection tools included demographic obstetric questionnaires, including obstetric information and demographic data, Cranly’s MFA scale, and NEO personality scale. Data were analyzed by the Pearson correlation coefficient and multiple regression, by using SPSS version 16.
    Results
    Findings from data analysis demonstrated a significant correlation between components of NEO personality with maternal-fetal attachment. Extroversion index (P < 0.001, R = -0.51) had the most significant relationship with MFA. Almost 33% of the variance in maternal-fetal attachment was predicted by personality trait. The extraversion ( = 0.48, P < 0.001) is the highest level of prediction. Neuroticism ( = 0.175), openness to experience ( = 0.131) and conscientiousness ( = 0.237), predicted the maternal-fetal attachment positively. Agreeableness ( = -0.026) was not predicted in the maternal-fetal attachment. In demographic variables, they were not predicted of MFA. There was a significant correlation between parity and maternal-fetal attachment (R = 0.190, P = 0.013).
    Conclusions
    Personality traits (except agreeableness) predict MFA for pregnant women. In addition, the psychological health of the mother and baby can be improved by identifying mothers based on personality traits, and therefore, by promoting behavioral attachment, health care providers should identify mothers who need additional psychological support during their pregnancy.
    Keywords: Personality, Pregnancy, Attachment, Fetal, Maternal
  • Shabnam Nadjafi*, Nasrin Hosseini, Mona Farhadi, Fatemeh Khojasteh Page 4
    Curcumin is a plant derivative with biological effects, including potential for the treatment of Parkinson’s disease (PD). It is known that monoamine oxidase B (MAO-B) is involved in PD due to its role in the degradation of various neurotransmitters like dopamine, the main declined factor in PD. Since MAO-B inhibitors (e.g. safinamide) are used as the support for the treatment of PD, we planned to evaluate the in silico interaction of curcumin with one subunit of the MAO-B enzyme in comparison with safinamide. The crystal structure of human MAO-B (PDB entry code 3PO7) was selected from the Protein Data Bank (https://www.rcsb.org). The molecular structures of curcumin (CID: 969516) and safinamide (CID: 131682) were obtained from Pub- Chem (https://pubchem.ncbi.nlm.nih.gov). Chimera 1.8, AutoDock Tools-1.5.6 software and AutoDock4 software were used for this in silico study. The results revealed that the binding energies (G)s of the conformations of curcumin and safinamide, showing the best downG, were -11.15 kcal/mol and -11.09 kcal/mol, respectively. Moreover, the inhibition constants (Ki)s of both ligands were near quantities. Hence, it may suggest that curcumin and safinamide form nearly similar stability with the subunit of the MAO-B enzyme. More experimental studies may reveal the similarity of curcumin with safinamide about the inhibitory effect on MAO-B.
    Keywords: Curcumin, Safinamide, Monoamine Oxidase B, Docking