فهرست مطالب

Trends in Phytochemical Research - Volume:1 Issue: 2, 2017
  • Volume:1 Issue: 2, 2017
  • تاریخ انتشار: 1396/03/11
  • تعداد عناوین: 8
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  • Pegah Nazemizadeh Ardakani, Shiva Masoudi * Pages 47-54

    The essential oils obtained by hydrodistillation and solvent free microwave extraction from the aerial parts of Artemisia tournefortiana were analyzed by GC and GC/MS. Forty-six components representing 82.3% of the hydrodistilled oil and thirty-nine components representing 81.0% of the solvent free microwave extraction oil of the plant were identified. The main components of the water-distilled oils were (Z)-βfarnesene (34.2%) and nonadecane (8.1%), whereas in the microwave extraction method 2-propenoic acid, 2-ethyl hexyl ester (30.0%) and spathulenol (19.5%) were the major constituents. The water-distilled oil of Artemisia tournefortiana was rich with regard to sesquiterpenes (64.5%), whereas the solvent free microwave extraction oil was rich with regard to sesquiterpene hydrocarbons (40.0%) and non-terpenoid compounds (39.3%) and the monoterpene hydrocarbon fraction was relatively small, representing 1.7% of the total oil. According to this study, the composition of the two oils showed significant differences in the contents of the main components.

    Keywords: Artemisia tournefortiana, Hydrodistillation, Microwave extraction, Gas chromatography-Mass, spectrometry (GC-MS), Essential oil
  • Satyajit D. Sarker *, Lutfun Nahar, Tauhidur Rahman Nurunnabi, S.M. Mahbubur Rahman, Md. Hossain Sohrab, Md. Morsaline Billah, Fyaz M. D. Ismail, George P. Sharples Pages 55-60

    Oxysporone, possessing a 4H-furo(2,3-b)pyran-2(3H)-one structure, is a fungal metabolite, first isolated from Fusarium oxysporum. Later, this compound was also reported from the fungal genera, Diplodia, Pestalotia and Pestalotiopsis. Oxysporone was patented as an antibiotic for the treatment of dysentery, and its phytotoxic property has been well-established. Interesting biological and chemical properties of oxysporone make this compound attractive for its potential biotechnological applications in agriculture, especially as a new agrochemical with a lower environmental impact. However, it requires further extensive bioactivity screening looking at beyond its established phytotoxicity and preliminary antifungal property. It has a simple chemical structure (C₇H₈O₄), and the hydroxyl group at C-4 provides options for synthesising numerous analogues by simply incorporating various functionalities at C-4, whilst keeping the main skeleton intact. This minireview provides a critical overview on the occurrence, production, synthesis, structure elucidation and bioactivities of oxysporone.

    Keywords: Oxysporone, Antibiotic, Endophytic fungi, Fusarium oxysporum, Structure elucidation
  • Claudio Frezza *, Alessandro Venditti, Ilaria Serafini, Alessandra Carassiti, Sebastiano Foddai, Armandodoriano Bianco, Mauro Serafini Pages 61-68

    Tinospora cordifolia (Willd.) Miers (Menispermaceae) is a glabrous, deciduous and trailing plant found in tropical India, China, Sri Lanka, Bangladesh and Myanmar. It is used to treat anemia, debility, diabetes, diarrhea, dysentery, dyspepsia, fever, jaundice, rheumatism, urinary and skin diseases and snake bites. Its air-dried stem powder was exhaustively extracted with methanol. The concentrated methanolic extract was adsorbed on silica gel (60-120 mesh) for the preparation of a slurry. The dried slurry was chromatographed over silica gel column packed in petroleum ether. The column was eluted with petroleum ether, chloroform and methanol successively in order of increasing polarity to isolate a variety of phytoconstituents including cetyl alcohol (1) along with new chemical constituents characterized as trans-cinnamoyl-2-n-hexanyl7-methoxynaphthyl amide (2), trans-cinnamoyl-2-n-pentanyl-6,7-dimethoxynaphthyl amide (3), trans-cinnamoyl-2-n-octanyl-7-methoxynaphthyl amide (4), β-D-arabinosylO-geranilan-10′-oate (5), 4,5,7-trimethoxy-2-naphthol-2-O-α-L-arabinofuranosyl(2′→1′′)-O-α-L-arabinopyranosyl-2′′-O-pentane (6), 5,7-dimethoxy-2-naphthol2-O-α-L-arabinopyranosyl-(2′→1′′)-α-L-arabinopyranosyl-2′′-O-decane (7) and 5-hydroxy-4'-methoxy-7-flavanoxy-(7→7'')-β-O-labdan-1-en-3''α,19''-olide-18''-oic acid (tinolabdenyl flavanone) (8). The structures of all the isolated phytoconstituents have been established on the basis of spectral data analysis and chemical reactions.

    Keywords: Tinospora cordifolia, Stems, Chemical Constituents, Isolation, Characterization
  • Mohammed Shagal Hassan, Dimas Kubmarawa, Peters Oladosu, Sunday Akuewanbhor Osemeahon Pages 69-76

    Tuberculosis kills approximately two million people annually. This study aimed at evaluating some selected medicinal parts that are used traditionally in Adamawa State, to treat tuberculosis and related symptoms against a microorganism that causes respiratory ailments. In this investigation, for new anti-tuberculosis lead molecules, ten medicinal plants species were selected and investigated for antimycobacterial activities following report of their therapeutic use in traditional medicine to treat infectious diseases such as tuberculosis. The stem-bark of the plants was extracted with methanol using soxhlet extractor. The crude extracts were screened for antimycobacterial activity against Mycobacterium tuberculosis using the broth microdilution method. The extract of Anogeisus leiocarpus showed strong activity at 0.312 mg/mL followed by Boswellia dalzielii with an activity of 0.625 mg/mL. Extracts of Acacia tortilis, Bombax constantum, Ceiba pentandra and Fiscus platyphylla showed activity at 1.25 mg/mL, 2.5 mg/mL, 2.5 mg/mL and 5.0 mg/mL, respectively. However, the extracts of Echinaceae angustifolia, Fiscus trichopoda, Fiscus sycomorus and Isoberlinia doka did not exhibit any significant antimycobacterial activity. The results from this study indicated that these six plants are viable potential sources of products active against Mycobacterium tuberculosis. This report also demonstrated the efficacy of Nigerian medicinal plants as potential agents in treatment/management of tuberculosis and related symptoms. The results have also validated traditional knowledge from the local people regarding the use of these plants to treat tuberculosis. Therefore, the six plants have potential to be developed on new anti- tuberculosis drugs.

    Keywords: Antimycobacterial activity, Diseases, Extracts, Tuberculosis, Medicinal plants
  • Ali Shafaghat *, Parisa Morrabi, Masoud Shafaghatlonbar, Farshid Salimi Pages 77-82

    The present study reports the preparation of biodiesel from Reseda luteola L. seeds oil using organic solvent. The hexane extract was obtained by Soxhlet apparatus and subjected to transesterification method to result simple esters. The final prepared composition was analysed by using GC-GC/MS. Thirty- three components representing 92.7% of the extracted oil of R. luteola were identified, among them, 9, 12-octadecadienoic acid methyl ester (23.8%), 9-octadecenoic acid methyl ester (12.2%), hexadecanoic acid methyl ester (9.9%) and n-decane (6.1%) were the major compounds. The organic extract of seeds from R. luteola detected as an important source of unsaturated fatty acid ester compounds.

    Keywords: Reseda luteola oil, 9, 12-octadecadienoic acid methyl ester, Biodiesel, GC-MS, Transesterification
  • Shahnaj Sultana, Mohammed Ali *, Mohammad Jameel Pages 83-92

    Tinospora cordifolia (Willd.) Miers, (Menispermaceae), a glabrous, deciduous and trailing plant found in tropical India, China, Sri Lanka, Bangladesh and Myanmar. It is used to treat anemia, debility, diabetes, diarrhea, dysentery, dyspepsia, fevers, jaundice, rheumatism, urinary and skin diseases and snake bites. Its air-dried stem powder was exhaustively extracted with methanol. The concentrated methanolic extract was adsorbed on silica gel (60-120 mesh) for the preparation of a slurry. The dried slurry was chromatographed over silica gel column packed in petroleum ether. The column was eluted with petroleum ether, chloroform and methanol successively in order of increasing polarity to isolate a variety of new chemical constituents characterized as trans-cinnamoyl 2-n-hexanyl-7-methoxynaphthyl amide (2), trans-cinnamoyl 2-n- pentanyl- 6,7- dimethoxynaphthyl amide (3), trans-cinnamoyl 2-n-octanyl-7-methoxynaphthyl amide (4), β-D-arabinosyl-O-geranilan-10′-oate (5), 4,5,7-trimethoxy-2-naphthol-2-O-α-L- arabinofuranosyl-(2′→1′′)-O-α-L-arabinopyranosyl-2′′-O-pentane (6), 5,7-dimethoxy-2-naphthol-2-O-α-L-arabinopyranosyl-(2′→1′′)-α-L- arabinopyranosyl-2′′-O-decane (7) and 5-hydroxy-4''-methoxy-7- flavanoxy- (7→7'''')- β-O-labdan-1-en-3''''α,19''''-olide-18''''-oic acid (tinolabdenyl flavanone) (8) along with cetyl alcohol (1). The structures of all the isolated phytoconstituents have been established on the basis of spectral data analysis and chemical reactions.

    Keywords: Tinospora cordifolia, stems, chemical constituents, isolation, Characterization
  • Raj Kishori Lal *, Sougata Sarkar, Mohammad Zaim Pages 93-102

    The present investigation was carried out to determine the stability over years among seventeen genetic stocks of turmeric assembled from different places in India for high and stable rhizomes yield. The differences among genetic stocks, years and g × e interactions were highly significant for rhizome yield. The stable genetic stocks were selected on the basis of stability parameters, high mean, regression coefficient (bi) around unity and mean square deviations from regression (s2di) near zero. The environmental indices for rhizome yield also indicated clear effects over the year’s i.e. 1.85 in year I followed by 9.95 in years II; -6.31 in year III and -5.29 in the year IV. The largest AMMI1 gain of the grand mean occurs over years for picking stable genotypes/clones. Further partitioning of genotypes on the basis of AMMI and Eberhart and Russell, (1966) model, the clones/genotypes T-8, T-12 and T-13 were highly stable; T-11 and T-14 adapted to the average stable in low yielding environment/year and T-9 ant T-17 genotypes/clones with below average stable suitable for high yielding environment were recommended for commercialization.

    Keywords: Anti-carcinogenic, Curcumin, multiplicative interaction, stable clones, Turmeric
  • Bachar Zebib *, Othmane Merah Pages 103-108

    This study aims to evaluate total phenolic content (TPC) and in vitro antioxydant activity (AA) of S. myrtifolia collected from Lebanon. TPC of S. myrtifolia were extracted by two solvents (methanol and water) and determined spectrophotometrically. The AA of both crude extracts were evaluated in vitro by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity method. Extracts exhibit relatively high levels of phenolic compounds which range from 343 ± 7.53 to 441 ± 10.70 mg GAE g-1 DW depending on the solvent used. Both extracts exerted hydrogen-donating ability in the presence of DDPH stable radical with a remarkable AA for aqueous extract. This study demonstrate that S. myrtifolia is a resource of biological active compounds which can reduces the risk of diseases and its effects which correlated with the antioxidant compounds.

    Keywords: Satureja myrtifolia, Wild plant, phenolic compounds, antioxidants, extracts