Chemical Methodologies
Volume:3 Issue: 3, May-Jun 2019

In this work, barium monoferrite nanoparticles have been successfully synthesized via a simple sol-gel auto-combustion method. The synthesis was based on the reaction between Ba(NO3)2 andFe(NO3)3 in aqueous medium, in present of lemon juice as surfactant and fuel agent. The products were characterized by X-ray diffraction, scanning electron microscopy, and photo luminescence techniques. Effects of lemon juice amount and the temperature have been investigated to achieve an optimal condition. It was found that the phase and morphology of products could be seriously influenced by these parameters. Vibrating sample magnetometer (VSM) was used to study the magnetism properties of BaFe2O4 samples.

The pursuit of rapid development in the area of catalysis, solar energy, environmental remediation, wastewater treatment and other aspects of ecological and sustainable chemistry has prompted substantial research by material chemists, physicists, academics and other scientists for the development of porous material. A lot of energy had been invested in this course by scientist, research organizations and public sector agencies from antiquity, but the resulting solution has been somewhat undesirable until two decades ago when Metal-Organic Frameworks (MOFs) appears to offer a glimpse of solution to those challenging issues. The adaptability, flexibility, uniqueness and usability of the metal-organic frameworks material, and its suitability to every facet of scientific and technological advancement has since triggered an incredible upsurge in studies aimed at uncovering more of the inherent influential properties of the materials, and its improvement for the betterment of material science and research world. This review is aimed at investigating some of the recent advancements/ breakthrough in metal-organic frameworks, synthetic methodologies and impending applications.

The interaction in the nanoclay is expected to be improved as the result of the amalgamation of hypalon chlorosulfonated polyethylene rubber (CSM) with nanoclay in the presence of compatibilizer agent nature rubber (ENR). Melt intercalation method was also applied to prepare CSM phases. The effect of ENR and nanoclay on the mixture behavior was also detected by scanning electron microscopy (SEM). Thermogravimetric analysis (TGA) contributed to scrutinize the thermal properties of the prepared NR/CSMs. The outcomes of the X-ray diffraction study are compatible with those of thermal analysis. The results indicated that CSM was infixed into nanoclay. Regarding the fact that the amount of the nanoclay content was lower than 12 wt%, Flynn-Wall-Ozawa (F.W.O) and Kissinger–Akahira–Sunose (K.A.S.), methods were applied to specify the energy of the apparent activation of the nano/hypalon systems holding 3, 6, 9 wt% of nano. The upshots demonstrated that increasing the thermal stability of hypalon was directed into boosting the nanoclay content. This divulges that there is an interplay between nanoclay, ENR and hypalon. Comparing to micro-filled ENR/CSM and ENR/CSM cross linked systems, it is predicted to conclude an enhanced thermal stability, higher values of Tg, better dispersion the nanoclay and more polish without any cracks.

The objective of the current study was to developed simple, precise and accurate isocratic reversed-phase stability indicating high performance liquid chromatography [HPLC] assay method validated the for determination of warfarin in solid pharmaceutical dosage forms. Isocratic reversed phase high performance liquid chromatography [RP-HPLC] separation was achieved on a SGE SS wakosil (150 mm × 4.6 mm i.d., C8RS 5 µm particle size) column using mobile phase of acetonitrile and 50 mM sodium hydrogen phosphate dibasic dihydrate buffer pH 3.0 (50:50 v/v) at a flow rate of 1.0 mL min-1, the injection volume was 20.0 μL and the detection was carried out at 280 nm using photo-diode array detector. The drug was subjected to oxidation, hydrolysis, photolysis and heat in order to apply stress condition. The method was validated for specificity, linearity, precision, accuracy, robustness and solution stability. The method was linear in the drug concentration range of 40-160 μg mL-1 with a correlation coefficient 0.9995. The precision (relative standard deviation RSD) amongst six-sample preparation was 0.22% for repeatability and the intermediate precision [RSD] amongst six-sample preparation was 0.70%. The accuracy (recovery) was between 99.95 and 99.15%. Degradation products produced as a result of stress studies did not interfere with detection of warfarin and the assay can thus be considered stability indicating.

The work has to develop polypropylene (PP) mixed for the purpose of compatible into the Prosopis juliflora bark powder (PB), Wheat husk carbon powder (WC) and Banyan carbon powder (BBC) using renewable bio resources. PB, WC and BBC were used as filler. They are relatively inexpensive and abundantly available in nature. The waste management were collected the wasted. PB, WC and BBC have been incorporated with composites. The mechanical and thermal studies were carried out to evaluate the effect of filler content on PP. The above filler has been studied for the mechanical and thermal properties increase with an increase in the filler content at optimum level 3% by weight. The tensile property of treated composites shows a higher value than neat PP matrix. The properties has been analyzed the variation value depend upon the porosity of the carbon and mixing the polymer composites.

Human serum albumin (HSA) is one of the main endogenous vehicles for biodistribution of molecules by blood plasma. Association constants and thermodynamic parameters for the interaction of HSA with doxorubicin were studied by docking. Docking study suggests that doxorubicin is able to interact with HSA by means of hydrogen bond with one arginine residue, whereas the hydroxyl group is inserted in a hydrophobic pocket. The estimated of Gibbs free energies (ΔG°) is equal to -9.1 kcal/mol for the best model. The negative values of ΔG° indicate a spontaneous process. The association constant value (Ka ≈ 8×103 L.mol−1) is favorable for its efficient biodistribution by blood plasma.

A simple method was developed to synthesize N-(3-(4-Chlorophenoxy)benzyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine by coupling 3-(4-Chlorophenoxy)phenyl)methanamine and 4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine. The products have been obtained in good yields and were characterized by spectral analyses and finally, docking studies were carried out. the formula is not displayed correctly!

We have developed novel route for the synthesis of β-Lactam by Fe(acac)3 based catalytic system with >90% yield. It is one pot Knoevenagel condensation of aldehyde with ethyl cyanoacetate followed by chemoselective reduction of the nitrile substituted C=C bond and nitrile functional group with sodium borohydride.Anti-microbial activity of the compounds exhibited at lower concentration against gram positive, gram negative bacteria and yeast with minimum inhibitory coIncentration (MIC) as low as 16 µg/mL. Compound have low hemolytic activity at their respective MIC. These derivatives might be liable to be increase the permeability of the bacterial cell membrane, which was demonstrated by DAPI, FITC, PI uptake studies and atomic force microscopy imaging of the treated cells. One pot synthesis with anti-microbial activity of β-Lactam derivatives can be helpful to developed effective antibacterial agents.

During the present study, the structural, vibrational, electronic and biological properties of the novel antagonist LY2157299 as a transforming growth factor-β (TGF-β) receptor I kinase inhibitor are explored by quantum-mechanical (QM) and molecular docking methods. The characterization of the title compound is done using FT-IR and UV-Vis spectroscopy methods. The above computations were carried out using density functional theory (B3LYP) method with 6-31+G(d,p) basis set. The frontier molecular orbitals (HOMO and LUMO) energies were used to calculate the global reactivity indices of the said compound. The results explored the stability, reactivity and bioactivity of the compound under study. To identify the nucleophilic and electrophilic sites in the said compound, the molecular electrostatic potential (MEP), electron localization function (ELF) and Mulliken charge distribution graphs were generated. The present paper further explains the ligand-protein interactions through molecular docking investigations. The results of the molecular docking studies indicate that the most important interactions between the ligand and protein are related to the residues His 285, Val 341, Lys 342, His 283 and Glu 284.