فهرست مطالب

Journal of Basic Research in Medical Sciences
Volume:3 Issue: 2, Spring 2016

  • تاریخ انتشار: 1394/12/11
  • تعداد عناوین: 8
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  • Masoumeh Shohani, Mahboobeh Rasouli, Fatemeh Shohani*, Kourosh Sayehmiri Pages 1-10
    Introduction

    Menopause is the most important event in middle-age. Women, in this period, face several changes. Vasomotor symptoms and skin changes are prevalent in the middle-age. This study, mainly, was performed identifying the vasomotor symptoms and skin changes in menopausal women.

    Materials and methods

    Study sample was consisted of 150 women who have visited the healthcare centers, experienced natural menopause as discontinuity of menstrual at least for 12-monthes. They have been selected randomly. Survey instruments were structured questionnaire, informational records, symptoms and signs checklist, centi-meter and balance and the data collecting method was through interview, observation, and examination. The data were analyzed using logistic regression.

    Results

    According to study results, skin warming and hotness (55.3%), hands and legs nipping (63.3%), hirsutism of pinion lip (27.3%), reduction of armpit hair (38%), acne (12%), Skin extenuation and wrinkling (51.3%) were reported. The most important point of the study is the significant relationship between amount of tea consumption and flushing severity (P=0.008, OR=3.18). Also, there was a significant relation between education and menopause duration, sleep disorders and severity of flushing, menopause duration and skin collagen reduction (P<0.05).

    Conclusion

    Skin and vasomotor changes is prevalent in these women. Flushing severity influenced by tea consumption, such that drinking more tea will decrease the flushing, is the start point of more researches in this field.

    Keywords: Signs, Symptoms, Skin, Menopausal women, Vasomotor system
  • Hassan Boustani, Hossein Ayatollahi, Hossein Rahimi, Samaneh Boroumand Noughabi, Masoumeh Gharib, Mohammad Alidadi, Arezoo Shajiei, MohammadHadi Sadeghian* Pages 11-19
    Introduction

    Apoptosis is an important mechanism in both physiological and pathological conditions. The BCL2 family of proteins plays a critical role in regulation of apoptotic cell death. Up and down regulation of BCL2-like 12 (BCL2L12), a new member of the BCL2 family, has been reported in several malignancies. However, the expression level of BCL2L12 rarely has been studied in leukemia. This study was designed to investigate the mRNA expression of BCL2L12 in patients with acute leukemia.

    Materials and methods

    90 patients with acute leukemia as case group and 90 healthy persons as controls, were participated this study. RNA was extracted from peripheral blood samples. Expression level of BCL2L12 mRNA was evaluated by a quantitative real-time polymerase chain reaction (qRT-PCR) method and its association with clinical and laboratory findings was analyzed.

    Results

    The expression of BCL2L12 mRNA was significantly lower in acute lymphoblastic leukemia (ALL) cases comparing the controls (P<0.001), while it was not significantly different in acute myeloid leukemia (AML) samples compared the control group. In addition, there were higher BCL2L12 level in females (than in males) and in patients with t(1221) in ALL patients. There was no association between BCL2L12 expression level and other clinical and laboratory findings of AML patients.

    Conclusion

    BCL2L12 seems play a role in the pathogenesis of ALL.  Further studies with larger sample size is needed to clarify its probable impact on prognosis and therapeutic response.

    Keywords: Acute myeloid leukemia, Acute lymphoblastic leukemia (ALL), BCL2L12, Apoptosis
  • Seyed Rahmatollah Mousavi Moghadam, Somayeh Malekian*, Maryam Karamshahi Pages 20-25
    Introduction

    Mental health is a branch of science focused on promoting welfare, social welfare, and life health which is related to all periods (from birth to death) and aspects of life (family environment, school, university, appointment, and society). Personality is a collection of mental characteristics that consistently exists within individuals and influences their behaviors and thoughts. Self-control as one of the unique personality characteristics varies from one person to another.

    Materials and methods

    The present study is a correlational descriptive study. The target population of this research includes all graduate students of public and clinical psychology studying in Islamic Azad University of Ilam during academic year of 93-94. According to statistics there were approximately 536 students in this field. Out of this number 224 students were selected through simple random sampling. Measurement instruments included: Tangney and Baumeister (2004) Self-Control Scale, NEO Five-Factor Inventory, and Goldberg General Health Questionnaire. For the analysis of findings of this study Kalmogorov–Smiranov test, correlation, and regression analysis were run through statistical software of SPSS.

    Results

    Results of this research showed that personal characteristics and self-control predicted 86% of variance that is, significantly predicted the level of mental health among students. Results of correlation revealed significant relationship between self-control and mental health. In addition, there were significant relation between personality traits and self-control. In other words,   it can be said that personality characteristics have a substantial role in predicting mental health and there is also significant relationship between the variables under study.

    Conclusion

    It can be said that self-control is one of the most important personality characteristics that influences individuals’ mental health.

    Keywords: Personality characteristics, Self-control, General health
  • Zahra Khalili, Mohsen Taghadosi*, Hamidreza Gilasi, Ali Sadrollahi Pages 26-34
    Introduction

    Elder abuse is among the major social health problems in today`s communities, and has significant effect on decreasing the health and security level in this group. The current study aimed to evaluate the prevalence and associated factors of abuse among the elderly in Kashan, Iran.

    Materials and methods

    This cross sectional study was conducted on 500 people over 60 years old in Kashan, Iran in 2014. Subjects were randomly selected from 10 healthcare centers of Kashan. Data were collected using elder abuse questionnaire. Cronbach alpha coefficient of the questionnaire was determined as 0.975. Data were analyzed by SPSS version 13. Pearson correlation coefficient and logistic regression analysis were used for data analysis. The statistically significant level was P<0.05.

    Results

    Results of the current study showed that 80% of subjects have experienced at least one type of abuse during the last year. The highest rate of abuse was in the form of financial abuse (45.6%), and the lowest was in ostracizing (16.6%). There was a statistical significant relationship between the elder abuse and variables such as sex, age, number of children, marital status, living arrangement, residential situation, home properties, monthly income, insurance situation, illness history, walking ability and using mobility aids. Logistic regression analysis also showed significant relationship between the elder abuse and unemployment, living in an apartment, and the age range 71-80 years.

    Conclusion

    Considering the high prevalence of abuse among the elderly, clarification of this phenomenon is considered as one of the main priorities, which can be achieved only through multidisciplinary approach in the community, and needs cooperation and collaboration of all community members.

    Keywords: Prevalence, Elder, Abuse
  • Ayat Moradipour, Afra Khosravi*, Mohamadreza Mehrabi, Sara Faryadian Pages 35-40
    Introduction

    Helicobacter pylori (H. pylori), is a bacterium responsible for upper gastrointestinal tract diseases. The 16s rRNA is a common H. pylori gene which are usually preferred for diagnosis purpose. The aim of this study was to determine the prevalence and abundance of 16s rRNA in fecal samples and also evaluate correlation between the level of 16s rRNA and activities of the cytokines, TNF-&alpha and IL-1&beta, in serum.

    Materials and methods

    The present study was performed on 84 subjects with digestion problems. Fecal and blood samples were collected and 16s rRNA gene was assayed using PCR. The serum levels of TNF-&alpha and IL-1&beta levels were measured by enzyme-linked immunosorbent assay (ELISA).

    Results

    The results of the study revealed that there was a positive correlation between the 16s rRNA gene, H. pylori stool antigen (HPSA) and TNF-&alpha cytokine. The study also noted that with every unit of increase in either of the quantified parameters of HPSA and IL-1&beta, the presence of 16s rRNA in fecal samples, showed a 2.98 and 1.01 times rise, respectively.

    Conclusion

    According to the obtained results, it may be concluded that activities of cytokine TNF-a correlated well with the presence of HPSA and 16srRNA gene in the stomach’s lining. Increase in the activities of HPSA and TNF-a cytokine could be associated with the presence of 16s rRNA in feces.

    Keywords: Helicobacter pylori, 16s rRNA, TNF-α, IL- 1β, HPSA
  • Kourosh Sayehmiri, MohammadReza Kaffashian, Elahe Ranaei* Pages 41-45
    Introduction

    Congenital anomalies are a common cause of disability and mortality in newborns and their treatments involves high costs for the society. This study aimed to investigate the prevalence of congenital anomalies and their causes.

    Materials and methods

    This research was a descriptive-analytical study and the population included all the newborns in hospitals of the city of Ilam in 2011. Variables of abnormality type, birth status, and medical and genetic illness histories were included into the data collection forms. Data was analyzed through Chi-square tests and Fisher's exact test using SPSS software.

    Results

    Of 460 neonates, 5.4 percent (25 cases) had died at birth and 3.7 percent (16 infants) were born with a birth defect. 43.8 percent of malformed babies had a family history. 31.3 % of the malformed babies had genetic syndromes, whose parents had consanguineous marriage. 18.8% of babies with defects in the central nervous system and cardiovascular system showed a similar percentage of disorder. The defect in the urinary system, head and neck each accounted for 12.5 percent.

    Conclusion

    This study shows that consanguineous marriages can be the most common genetic cause of genetic syndromes.

    Keywords: Congenital malformations, Genetic syndromes, Consanguineous Marriages
  • Fariba Mokhtari, Narges Sharifinia, Zahra Mokhtari, Mostafa Qorbani, Hadad Shafieyan, Babak R. Astgari Mehr, Amin Mirzai, Zahra Shafieyan, Morteza Mansourian* Pages 46-52
    Introduction

    Crimean Congo hemorrhagic fever (CCHF) is a Zoonosis disease. The aim of this study was to examine the effect of educational intervention on practice improvement of employees in healthcare centers and meat distribution centers of Ilam province in relation to Crimean Congo hemorrhagic fever.

    Materials and methods

    Participants in present quasi-experimental study were 200 employees of healthcare centers and 75 workers of meat distribution centers that were selected through simple random sampling. Data were collected at baseline and 6-weeks after intervention using two 38-item and 50-item questionnaires. Data were analyzed by the SPSS software. P<0.05 were considered to be statistically significant.

    Results

    Before the educational intervention, 20.6% of the healthcare centers employees had poor knowledge, 61.8% and 17.6% had average and good knowledge, respectively. After educational intervention, these percentages were 2%, 22.1% and 76% in that order. The workers’ knowledge level in centers of meat processing-distribution before training was 64% poor, 34.7% average, and 1.3% good but after education, the knowledge levels reached to 5.3%, 45.3% and 49.3% respectively (P<0.05). Moreover, Attitude of employees in healthcare centers and meat distribution centers significantly increased after intervention (P<0.05). But, there were not significant changes in performance of two groups before and after educational intervention

    Conclusion

    The results of present study showed the effect of educational intervention on improvement the knowledge, attitude of employees in healthcare and meat distribution centers. So, implementation of an educational program for employees at a wider scale could promote their health.

    Keywords: CCHF, Behavior, Health care employees, Intervention
  • Afshin Yarmohammadi, Fatemeh Keshavarzi*, Mokhtar Farhadian Pages 53-57
    Introduction

    Fragile X syndrome (FXS) is one of the most prevalent genetic causes of developmental disability, representing the most frequent form of inherited severe cognitive deficit. The present study was undertaken to investigate FXS and its prevalence in moderate mentally retarded people in patients.

    Materials and methods

    Nineteen people with moderate mental retardation (MR) who were clinically suspicious to have FXS were screened for FXS by using cytogenetic and molecular methods. Blood samples were collected and cultured in specific culture media. G-Banding method was used for karyotyping. To ensure correct results of cytogenetic testing, four suspected case of FXS were tested by PCR. Results were analyzed using logistic regression analysis.

    Results

    Four patients (4%) were found to express fragile X site at q27.3. The results showed that the relationship of FXS with familial, economic status was not significant, but the relationship of FXS with MR and family history was significant.

    Conclusion

    The frequency of FXS positive cases found in this study is similar to other reports of FXS in preselected patients.

    Keywords: MR, FXS, FMR1, Cytogenetic