Iranian Journal of Diabetes and Obesity
Volume:11 Issue: 4, Winter 2019

We conducted this study to compare the psychological effects between diabetic patients taking fast and non-fasting counterparts to better investigate the effects of fasting on mental health of diabetes sufferers.

This study was a prospective cohort conducted among diabetic patients. In this study, two types of fasting and non-fasting patients were invited to take part. During One week before and after the Ramadan, all patients were asked to complete 28-scale General Health Questionnaire (GHQ).

In this study, 116 patients who were suffering from diabetes completed the study. They were compared with each other in format of three groups (two fasting and one non-fasting). Mean changes of total and subscales' score were negative in nearly all groups but there were no significant difference between groups. In addition, total and subscale A, B and C scores significantly increased (positive change) but subscale D score didn’t change in fasting patients during this month.

The results of present study revealed that fasting during the whole month of Ramadan can exacerbate patients' general health in comparison with non-fasting patients. However, because we can't determine whether this finding is attributed to fasting regardless of diabetes or has been resulted from the co-existence of fasting and the disease, it is recommended to design a study to compare diabetic and healthy fasting individuals.

Menopause is a normal biological process associated with hormonal and metabolic changes. The purpose of this study was to investigate the effect of combined training on estradiol levels and some metabolic risk factors in obese and overweight postmenopausal women.

In this quasi-experimental study, 24 postmenopausal women were randomly divided into experimental and control groups. Subjects of experimental group were performed 10 weeks of combined training including resistance and aerobic exercises. Control group did not participate in any exercise training. Fasting glucose, insulin, estradiol, HOMA-IR and body fat percentage measured at the beginning and after training.

There were no significant differences in estradiol (P-value: 0.87), glucose (P-value: 0.09), insulin (P-value: 0.11), HOMA-IR (P-value: 0.08) and body fat percentage (P-value: 0.24) between experimental and control groups after combined exercise training.

This study showed that 10 weeks of moderate-intensity combined exercise training has no effect on serum estradiol level and insulin resistance in overweight/obese postmenopausal women.

Pioglitazone is one of the oral medications of type 2 diabetes (T2DM). The purpose of this study was to evaluate the effect of pioglitazone on asthma and diabetes treatment outcomes among patients with concurrent asthma and T2DM.

We conducted a quasi-experimental study on 11 patients with concurrent asthma and T2DM in Yazd Afshar Hospital and Yazd diabetic research center 2014-2017. The inclusion criteria were patients between 20-60 years old, at least one year with concurrent asthma and T2DM (documented with spirometer, bronchodilator test), ejection fraction more than 50%. Patients who were smoker, on oral corticosteroids, phenobarbital, methotrexate, rifampin, phenytoin and gemfibrozil were excluded. Laboratory tests (FBS, HbA1c, 2hpp, leptin), spirometer test, exhaled nitric oxide were done before and after 10 weeks of pioglitazone medication. All patients were visited every two weeks. The before and after pioglitazone treatment differences were checked by paired t-test and Wilcoxon Rank sum test.

The mean (± SD) age of participants was 55.81 (±7.66). The median of differences of leptin (p-value: 0.885), FEV1 to FVC (P-value: 0.185), FEV1 (p-value: 0.386), NO (P-value: 0.574), FVC percent (P-value: 0.477), FEV1 percent (P-value: 0.515) did not differ before and after pioglitazone treatment.   

Our finding suggested that pioglitazone may not be effective in the treatment and improvement of respiratory function in T2DM with concurrent asthma.

This study aimed to investigate the effects of moderate to high-intensity aerobic exercise on HbA1c (Glycated hemoglobin), FBS (fasting blood sugar) and cognitive function in mild cognitive impairment prediabetes patients.

Seventeen elderly mild cognitive impairment (age 55-70) men and women were selected and were randomly divided into 2 groups as aerobic (n=10) and control (n=10). Six subjects were excluded during the study. Finally, 14 subjects were continued the exercise program. Assessments were done at baseline and 12 weeks after intervention. The 12-weeks aerobic exercise program consisted of 90 min sessions in length 3 days per week under the supervision of the exercise specialist. Cognitive function, HbA1c, and FBS were evaluated. The differences in all variables (one way ANOVA), correlation (Pearson single correlation) and relative changes between baseline and 12 weeks (paired T-tests) were investigated.

HbA1c, FBS decreased significantly in the aerobic group whereas cognitive function increased significantly after 12 weeks aerobic (P-value< 0.05 for all). Also, the change of cognitive function was significantly associated with a change of FBS (r= -0.84) after a 12-week aerobic exercise (P-value: 0.011). Differences between groups in HbA1c, FBS and cognitive function (Mini-Mental State Examination) were not significant.

Aerobic exercise may improve HbA1c, FBS and subsequently cognitive function in prediabetes elderly subjects. Therefore, a decrease in glycemic indicators could lead to improve cognitive function.

Low physical activity is the fourth risk factor of death worldwide. Approximately 27% risk of diabetes is reduced by 150 minutes of moderate physical activity per week. The present study was designed to determine the predictors of physical activity promotion among type 2 diabetic patients.

In this cross sectional study 320 patients with type 2 diabetes were included. The data collection tool was a questionnaire, consisting of three main parts; demographic characteristics, International Physical Activity Questionnaire (IPAQ) and Theory of Planned Behavior (TPB) theoretical constructs. Statistical software package SPSS (SPSS Inc version 20) used for all statistical analyses. To determine physical activity and predictive factors a series of logistic regression and bivariate correlations and descriptive analysis were computed.

About 57.5% of patients had moderate levels of physical activity. Significant positive correlation between subjective norms and attitudes toward behavior (P-value= .0001) was seen. Significant positive correlations between behavioral intention and attitude toward the behavior (P-value= .0001) and subjective norms (P-value= .0001) was observed.

The results of the present study showed TPB based physical activity and demographic variable have key role in diabetic patient physical activity levels. To promote physical activity these findings can be used to design effective interventions

Few studies have been conducted on variations of the central nervous system of diabetic patients and much fewer investigations done on the cerebellum of diabetes patients. The current research aims to investigate the effect of endurance training on neurotrophic factors affecting the cerebellum in the diabetic rat.

This study is experimental.Twenty Wistar rat were randomly allocated in four groups including: (1) control (n=5), (2) diabetic exercise (n=5), (3) healthy-control (n=5), (4) and exercise-healthy (n=5). Diabetes were induced by intraperitoneal Streptozotocin injection. The endurance exercise training was performed at moderate intensity for six weeks. Expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) genes were measured using the Real-Time PCR method in the cerebellum of the rat. Two-way ANOVA test was used for comparing the means of expression of genes between groups. All statistical analyses were done using SPSS 22 software.

A significant increase was observed in the expression of NGF (from 1.03±0.11 to 1.61±0.24; P-value≤ 0.05) and BDNF (from 1.59±0.06 to 3.24±0.46; P-value≤ 0.05) genes in male rats with experimental diabetes and healthy subjects after six weeks endurance training.

Endurance training may be helpful for diabetic patients by increasing the neurotrophic factors and thereby preventing diabetes-related neural complications.

A clinically observable metabolic disorder often takes its root from modulation of transcriptional factors which in turn are responsible for perturbed protein expressions and their sequelae. Perinatal perturbations due to chronic prenatal exposure to a certain type of rice could predispose parents exposed to such ‘insult’ and their subsequent offsprings to metabolic diseases.

We investigated the effect of chronic prenatal exposure to different types of rice (in context of a balanced normal diet and a high-fat diet) on some insulin signaling genes using nulliparous Sprague Dawley rats. The rats were exposed to various predetermined rice diets for 90 days. After returning them to standard chow, they were mated with male rats raised on standard chow. The resulting pups (F1) and dams were sacrificed and their tissues were examined for modulation of genes related to insulin signaling.

Our results show that dams fed with white rice in context of standard diet modulated MAPK1, MAFA1 and SLC2A2. Also, germinated brown rice prevented dysregulation of MAPK1, and SLC2A2 in both dams and pups exposed to this diet in the context of a high-fat diet. In general, germinated brown rice retarded dysregulations due to high-fat diet exposure while white rice enhanced the dysregulatory effects of high-fat diet.

We conclude that chronic prenatal exposure to a certain type of rice, could be a factor to modulation of some genes related to insulin signaling pathways and that these modulation could be inherited by at least one generation of offsprings.

The use of non-enzymatic antioxidants in the form of dietary supplements has a positive effect on reducing oxidative stress, and preventing apoptosis as they interrupt free radicals. The aim of this study was to investigate the aerobic exercise and L-carnitine consumption impacts on diabetes induced apoptosis, oxidative stress factors, and mitochondrial enzymes in rats.

In this Clinical trial study, 45 male Wistar rats (200-300 g) were divided into six groups including sham, healthy control, diabetic control, diabetic & L-carnitine, diabetic & aerobic exercise, diabetic receiving L-carnitine & aerobic exercise . The rats attained a diabetic state with a single dose of STZ intraperitoneal injection (55 mg/kg body weight) and receiving L-carnitine 100 mg per day. The aerobic exercise protocol including five sessions per week was administered. The heart tissues of the dependent variables were measured by ELISA 24 hours after the last session of the exercise program. One-way ANOVA and Tukey's post hoc test at P-value< 0.05 were used to analyze the data.

result show that aerobic exercise and L-carnitine consumption have a significant effect on BAX (P-value= 0.001), Bcl-2 (P-value= 0.001), and SOD (P-value= 0.001) in diabetic rats.

The results of the present study confirm the role of aerobic exercise and L-carnitine in improving the indices of apoptosis and oxidative stress in type 2 diabetic rats

Aerobic training and berberine chloride include antioxidant characteristics. In this study, aerobic training and berberine chloride intervention on the activity of antioxidant enzymes and lipid peroxidation of pancreatic tissue were investigated in type 1 diabetic male wistar rats.

In the current study, 56 Wistar male rats were randomly assigned to seven different groups (n= 8), these groups include healthy control, diabetic control, Berberine-treated diabetes (15&30 mg/kg), aerobic training-treated diabetes, Diabetes treated with Berberine and aerobic training (15&30 mg/kg). The aerobic training schedule consisted of 6 weeks treadmills with a frequency of 5 sessions per week. The Berberine was also fed a specific dose every day and a half before training. The superoxide dismutase, glutathione peroxidase, catalase, and malondialdehyde were assessed using ELISA method.

The results showed that aerobic training, as well as the intervention of Aerobic Training and Berberine chloride, had a significant effect on the increase of antioxidant enzymes SOD and CAT in the pancreatic tissue groups (P-value< 0.05), but did not significantly affect the GPX level (P-value> 0.05). There was a significant decrease in MDA level in all treatment groups (P-value< 0.05). In diabetic groups that received both treatments at the same time, the MDA level more decreased (P-value< 0.0005).

The aerobic training and berberine chloride concurrent intervention have a greater effect on the antioxidant enzymes in the pancreatic tissue of diabetic specimens. Therefore, it is recommended that aerobic training be done with berberine chloride.