مجله دانشکده علوم پزشکی نیشابور
پیاپی 26 (بهار 1399)

The heart rate deflection point (HRDP) is the heart rate deviation point of the straight line that is defined in the study of the relationship between work and time and it is used as a criterion for intensity of exercise planning. The purpose of the present study is to review the Methodological approach of heart rate deflection point the new methods for determining this point. Finally, based on the standard criteria and based titles on of the articles, only remained 16 articles based on which the study was conducted. The results of the studies indicated that in the physiological mechanisms related to HRDP, the effect of cardiac muscle, catecholamine and the nervous system, the role of potassium and Lactic acid are among the possible mechanisms involved and in Methods for determining HRDP, determining the base heart rate, methods of calculating and measuring HRDP and exercise protocols were the most important Methodological approach of this point. The results indicate that disagreement about the ability of HRDP to determine the anaerobic threshold related to the methodology of HRDP measurement. Infect, it affects the definition of the anaerobic threshold. Therefore, studies on it continue.

Glanzmann's thrombasthenia is the hereditary disease of abnormal function in the platelets. It extends the time needed to bleeding control associated with the absent or inadequate platelet accumulation. Despite being rare, this disease Given the direct relationship between the rate of cousin marriages and the disease prevalence. A main problem in the treatment of the disease is performing particularly major surgeries. In the present case report we stated a case management of the hemorrhagic ovarian cyst with a history of Gelzmen's disease.

With a history of Gelzmen's disease, adolescent girl presented with a pain in the abdominal area. After performing ultrasound and taking medical history and the related tests conducted, the patient was diagnosed with the hemorrhagic ovarian cyst. Before the surgery, the patient received three vials of the recombinant activated factor VII. During and after the operation, she was received three vials in every two hours, and three vials every six hours until homeostasis. Finally, the patient was discharged four days later with satisfactory general condition

It may be diagnosed after circumcision and menstruation in men women respectively. Concerning the previous studies as well as our experience, we could manage the patient bleeding during and after the surgery for treatment of the hemorrhagic ovarian cyst by preoperative injections of the platelets and the factor VII during and after the operation.

Breast cancer is the most common cancer among women. One of the approaches to prevent and treat various cancers is to use plant compounds. The aim of this study was to investigate the effect of S. setifera essential oil on MCF-7 human breast cancer cell line and comparing it with Doxorubicin as a known anti-cancer medicine.

Cells are treated by 0.01-0.025 µl/ml of essential oil at at 24, 48 and 72 hours and cell viability and colony formation ability were quantified. Also, essential oil compositin is analyzed by GC-Mass.

The S. setifera essential oil decreased the viability and CFU of cells, significantly. EO IC50 was reported as 0.0206, 0.0175 and 0.0173 µl/ml over 24, 48 and 72 hours. In addition, the S. setifera essential oil GC-Mass analysis showed that most compounds are related to hydrocarbon alkanes and terpenoids.

Probably the essential oil cytotoxicity effects are related to hydrocarbon alkanes and terpenoids compounds.

The purpose of this study was to compare nurses 'and patients' viewpoints about the quality of nursing care.

In this descriptive-analytical study, 300 hospitalized patients and 100 nurses working in 22 Bahman Neyshabur teaching hospital participated. Patients were selected through systematic random sampling and nurses were selected through census. QUALPAC questionnaire was used for data collection.Descriptive statistics, Kruskal–Walli  and U-Mann-Whitney were used to analysis the collected data.

The results of the present study show that the quality of nursing care from the viewpoint of nurses and patients is in a desirable level.

The results of the present study show that the quality of nursing care from the viewpoint of nurses and patients is in a desirable level.

Diabetes is one of the serious medical problems in recent years. The purpose of this study was to investigate the effect of six weeks’ endurance training and L-carnitine consumption on Bax / Bcl-2 and oxidative stress indices of heart tissue of diabetic rats.

In this experimental study, 45 male Wistar rats (weighing 20 ± 250 gr) were randomly divided into 6 groups including healthy control, diabetic control, sham, exercise, L carnitine and exercise and L-carnitine. Rats were diabetic peritoneally injected with nicotinamide at a dose of 95 mg / kg body weight and after 15 minutes of STZ injection of 55 mg / kg body weight. Rats receiving El Carnitine received daily 100 mg of l-carnitine orally. Aerobic exercises were performed for 5 weeks a week, from 9:00 to 11:00, for six weeks. The variables were measured by ELISA and ASA kits and in the heart tissue. One-way ANOVA and Tukey's post hoc test were used to analyze the data using Shapiro Wylak test.

The results showed that increasing endurance training and L-carnitine consumption had a significant effect on GPX (P = 0.001), MDA (P = 0.001), and Bax / Bcl2 heart rate (P = 0.001) in diabetic rats.

According to the findings of this study, the use of aerobic exercise and L-carnitine (in consultation with the physician) are recommended to reduce the complications of diabetes.

Marital infidelity is considered to be one of the most important traumatic factors for couples and families, and it is also a prevalent phenomenon for family and marital therapists. The present research was conducted by the aim of investigating the effectiveness of group compassion-focused counseling on internalized shame among women affected by marital infidelity.

The present study was a semi-experimental one that was conducted by pretestposttest and follow-up with control group design. The research population included all the women affected by marital infidelity referring to counseling centers in Gorgan, Iran, in 2019. The research sample composed of 24 women who were selected by purposeful sampling method and were assigned into experiment and control groups by random assignment method (12 subjects per group). The data gathering tool was Cook’s Internalized Shame Scale (1993). Group compassion-focused therapy was provided in 13 120-minute sessions for the experiment group. The data were analyzed by variance analysis test with repeated measures.

The results of variance analysis with repeated measures showed that group compassion-focused counseling led to a decrease in internalized shame in the subjects of the intervention group in the posttest and follow up stages. Moreover, the therapeutic intervention exerted a positive and significant effect on the components of internalized shame (shyness, self-esteem) (p < 0.01).

According to the confirmation of the effectiveness of the compassion-focused approach, family counselors and therapists can use this therapeutic model for reducing the traumas caused by marital infidelity.

Narcissistic personality disorder is one of the disorders that has many different manifestations in clinical and research environments that make it difficult to diagnose and treat this disorder.The aim of this study was evaluating the validity and reliability of the brief version of pathological narcissism (B-PNI) in Iranian society.

This was a descriptive correlation study and the study sample was composed of 400 university students who were selected by available sampling. After getting author’s agreement, the main version of Brief Pathological Narcissism Inventory was translated through backward translation technique and the scale was used for pilot test on 50 people. Convergent validity was calculated using the Narcissistic Personality Inventory (NPI-16). 

Confirmatory factor analysis on grandiose narcissism and narcissistic vulnerable narcissism indicated good validity of the inventory in these factors (after deleting one item). Composite Reliability of the subscales ranged from 0.68 to 0.83. The Cronbach’s alpha coefficients obtained for this scale and its subscales from 0.63 to 0.83. This scale showed a good test-retest reliability in 15 days(r=0.984, p=0.001). Grandiose subscale just has shown the convergent validity with Narcissism personality Inventory(r=0.4, p=0.001) and there was not a meaningful correlation with Vulnerable narcissism(r=0.07, p= 0.6). 

The Farsi version of the Brief Pathological Narcissism Inventory has a desirable validity and reliability and could be used in clinical activities and so in psychological researches in Iran.

Electrocoagulation process is one of the most effective treatment methods at among of the oxidation processes due to its unique properties such as simple design and extensive application for treating of industrial wastewater. To promote this process, different ways have been proposed. In this study, the electrocoagulation process was incremented by the placement of steel wool and platinum electrodes and its potential was evaluated by decolorization of crystal violet (CV) from aqueous solution.

the colored solution was prepared from CV powder by its dissolution in distillated water. Spectrophotometric method (600 nm) was used to determine the color content. Electrocoagulation experiments were conducted in a 1000 mL backer and at a batch method. To evaluate the kinetic studies, first and second order models were used. Toxicity tests were also performed using coliform bacteria to ensure the reduction of crystal violet toxicity.

The results showed that the process could remove the colored solution with a high percentage rate about 99.63% under optimal conditions (pH 9, time of 60 minutes, applied current 0.4 amperes and color concentration about 200 mg/L). The microbial toxicity test also indicated that the treated wastewater in this method can be reused or discharged in the environment.

Based on the results, the electrocoagulation with steel wool-platinum electrode arrangement can be effectively used in the treatment of color containing industrial wastewater.

There are different strategies to reduce employees’ exposure to chemical contaminants and their emission in workplaces out of which local exhaust ventilation is the most common engineering system that best suits our needs. The current study aims to design and install a local exhaust ventilation to control exposure to soldering fumes in an electronic components manufacture industry.

This is an Experimental study carried out in three steps in an assembly line for electronic components in Kerman in the summer of 2018: 1- collecting samples of contaminants produced during soldering 2- designing, manufacturing and installing a local exhaust ventilation 3- collecting samples of contaminants produced during soldering after designing an exhaust ventilation.

The results showed that employees had more exposure to tin and lead contaminants before designing and installing a local exhaust ventilation that was above the allowed rate. The results of designing an exhaust ventilation of 20.5 m3/min showed that tin and lead fumes rates could reach below the allowed rates in all workplaces.

The investigation and comparison of the allowed rates of exposure to soldering fumes and the density rates in workplaces before and after designing the local exhaust ventilation proved the high efficiency of controlling methods in the assembly line of electronic components

Betatrophin and irisin are a liver and muscle tissue produced proteins that regulate the triglyceride metabolism as well as glucose homeostasis. This study was designed to evaluate the level of betatrophin and irisin in obese rats before and after aerobic training.

Twenty four, 8-week-old male Wistar rats (249.8±11.2g) were selected and purchased for the research. After obesity induction by high-fat diet, the animals were randomly divided into two groups: exercise (n = 12) and control (n = 12). Also a match group with normal weight was selected for baseline comparisons. The animals trained 60 min/day, 5 days/week for 10 weeks. Body weight, lipid and glycemic profiles, and betatrophin and irisin levels were assessed after 10 weeks of training.  The data were compared using analysis of variance (P<0.05).

Results showed that weight mass (P<0.01), plasma total cholesterol (P<0.02), triglyceride (P<0.05) and fasting glucose (P<0.04) were reduced in obese rats following the exercise training. Plasma betatrophin was significantly reduced in exercise compared to sedentary groups (P<0.02). Conversely, irisin concentration was significantly elevated with exercise (P<0.03).

The data demonstrated that moderate intensity aerobic training prevented obesity-induced cardiovascular disorders simultaneously with improvements in betatrophin and irisin levels in obese rats.

The aim of this study was to evaluate the effectiveness of the “well-being therapy" method on clinical syndrome in patients with major depression as a randomized clinical trial.

This randomized clinical trial study was performed on patients with major depression who referred to the psychological clinic of Shamim, Bojnurd city. Participants eligible to enter the study were randomly assigned to the intervention and control groups. In the intervention group Well-being therapy was performed in 8 sessions of 50 minutes and once a week, and the control group did not receive any treatment .Both groups were evaluated before and after the study and two months later by the Second Depression Beck Depression Inventory (BDI-II). Data were analyzed by generalized estimation equation (GEE) in STATA12 statistical program and p-value <0.05 was considered statistically significant.

A total of 24 subjects had inclusion criteria in which 12 participants were randomly assigned to each group. The frequency of women in the intervention and control group was 67.0% and 72.0%, respectively. The results of the GEE test showed that in the well-being group, the mean depression scores decreased 10.90 rather than the control group (p-value <0.0001).

The results of this study showed that the well-being of patients with major depression reduces their depression.

Malva sylvestris is a symbol of calmness and have antioxidant and radical scavenging properties. The objective of this study was to investigate the antidepressant effects of hydroalcoholic extract of Malva sylvestris leaves in mice using forced swim and tail suspension tests.

In this experimental study, 42 male mice were distributed in 6 groups (n=7), including vehicle (normal saline), negative control (reserpine), fluoxetine (positive control), and three groups treated with hydroalcoholic extract of Malva sylvestris (150, 300 or 450 mg/kg, i.p.). Forced swim and tail suspension behavioral tests were used to measure depression in mice. Antioxidant capacity and malondialdehyde (MDA) content in brain of mice were determined.

Reserpine treatment significantly increased the time of immobility in the behavioral tests. Fluoxetine and extract in all three doses in Forced swim (P<0.001) and at 300 (P<0.01) and 450 mg/kg (P<0.001) doses reduced the immobility time. Reserpine significantly increased MDA level, and decreased antioxidant capacity of brain. Fluoxetine and extract at 300 and 450 mg/kg doses increased antioxidant capacity and reduced MDA level of brain.

The results of this study suggest that Malva sylvestris leaves have antidepressant-like activity similar to fluoxetine which may be mediated by its antioxidant and radical scavenging components.
Keywords