مجله دانشکده علوم پزشکی نیشابور
پیاپی 27 (تابستان 1399)

The vascular endothelium represents a dynamic boundary between the circulation and the surrounding tissue. These single-layer endothelial cells act as a non-adherent surface for platelets and leukocytes and produce a variety of regulatory factors such as prostaglandins and nitric oxide. Endothelial Proliferative Cells (EPCs) are a rare population of cells that can be stimulated by various stimuli, including ischemia, exercise, cytokines, chemokines, hormones, and medications to help preserve endothelial health, prevent endothelial dysfunction, and increase the process of phototherapy.  These cells can improve the function of the ischemic organ organs by inducing angiogenic mediates in places with low oxygen storage or by stimulating the reconstruction of endothelial cells of the damaged blood vessels.  In this review study, signaling pathways, stimuli and factors affecting the production and activation of endothelial progenitor cells in normal and in exercise mode will be investigated. 

The results indicate that endothelial progenitor cells have an important role in the development of angiogenesis. There are two initial and delayed subsets for EPCs that delayed EPCs have the potential to differentiate into endothelial cells. Initial EPCs have more potential to promote vascular repair through paracrine.And in all stages of invoking, deployment, invasion and differentiation of these cells, the various subunits of intrigines are of great importance. Various factors, such as testosterone, palmitate, TNF-α, and physical activity, affect the accumulation of EPCs. Regular physical activity, especially aerobic activity, depending on the intensity and duration of exercise, improves the function of these cells.

The purpose of this study was to determine the effectiveness of mindfulness-based art therapy (MBAT) in decreasing stress levels and promoting life style in pregnant women referred to Neyshabur health centers in 2018

This study was interventional study, which was conducted on 84 pregnant women. Eighty-four pregnant women completed both the pre and post-study measurements. The MBAT group demonstrated a significant decrease in symptoms of distress and significant improvements in key aspects of the health-related style of life as measured by Health Promoting Lifestyle Profile-II questionnaire.

Independent t-test, after intervention, showed a significant difference in mean of lifestyle  and stress, interpersonal relationships, and responsibility in two groups (P <0.05); these changes were not significant in the control group.

This investigation of MBAT provides initial encouraging data that support a possible future role for the intervention as a psychosocial option for decrease in symptoms of distress pregnant women and improve lifestyle

With the advances in technology and communications, telecommunications and wireless systems, mobile phones worldwide and the number of BTS antennas are increasing in cities. Due to the dangers of these waves on human health, the purpose of this study was to investigate the electromagnetic radiation emission around BTS antennas in Karaj residential areas.

By field monitoring 57 stations in Karaj were selected. Three replicates were measured at 5, 10, 30 and 50 m intervals by a TES-92 calibrated instrument made by Taiwan. Statistical analysis was performed to compare the standard and the waves at intervals with SPSS software.

The results showed that as the distance from the antennas increased, the power density of the electromagnetic waves decreased. In addition, within 10 meters of the masts, the highest measured wave density was obtained with an average of 10.2222. There were significant differences at all distances except 5 and 30 meters (p <0.05) and the results were lower than ICNIRP standard.

Distance factor is the most important characteristic in determining the density of electromagnetic waves. It seems that the magnitude of the electromagnetic waves at 10 meters distance is more than 5 meters due to shading and environmental factors. The overall results indicate the safe conditions of electromagnetic waves caused by BTS antennas in the city of Karaj, which is recommended to monitor the installation of new antennas at safe distances to maintain the existing conditions.

Breast Cancer is the most prevalent type of cancer among women and is also the second major cause of cancer. Due to the acquired resistance of cancer cells against conventional therapies and recurrence of the sickness after treatment, new therapeutic strategies based on triggering apoptosis have been proposed. The purpose of the present study is to introduce a cytotoxic effect of biological silver nanoparticles toward breast cancer MCF-7 cells and evaluation of the caspase-activated DNase (CAD) gene expression at mRNA level.

Silver nanoparticles were synthesized according to the recent biosynthesize method. Afterward, the Silver nanoparticles were inspected using transmission electron microscopy (TEM) analysis. Different concentrations of 6.25, 12.5, 25, 50, 100, and 200 µg/ml of Nanosilver particles were treated on MCF-7 cells for 24 hours and the results were evaluated using the MTT assay and IC50 were measured. The level expression of CAD gene was evaluated using real-time PCR.

Silver nanoparticles were mostly spherical, having an average size of 9.13±4.86 nm.  Silver nanoparticles demonstrated a dose-dependent toxic effect toward MCF-7 cells. The IC50 value of silver nanoparticles was measured 49μg/mL. In addition, the expression of CAD decreased by 0.77 fold, compared to the control group.

The results of the present study demonstrated that the silver nanoparticles can induce cytotoxicity against breast cells and it is necessary to perform more tests against animal models.

The aim of this study was to evaluate the effect of six months’ resistance training and ginger extract on lipid profiles, body composition and selected liver enzymes in obese menopausal women.

In a semi-experimental trial, 48 obese menopause women were randomly and divided into 6 groups including control, ginger extract, resistance training and resistance training -ginger extract. resistance training was performed 3 sessions in a week, 30-60 minutes for 24 weeks. The subjects consumed ginger extract three times a day in 500 mg capsule for 6 months. 24 hours, 3 months and 6 months after the intervention in the 12-hour fasting condition, subjects from each group received blood samples and anthropometric characteristics. Data were analyzed by two-way ANOVA with repeated measures and Tukey post hoc test at the p<0.05.

Six months of resistance training was associated with a decrease in ALT (p=0.016) and AST (p=0.002) in postmenopausal women, but combined exercise-ginger supplementation was no significant effect on ALT and AST in postmenopausal women (P>0.05).

It seems to Longer Periods Regular resistance exercise compared with combined exercise-ginger supplementation have more health benefits for obese menopause women.

Flies due to transferring many of the pathogens, in different areas, especially in conditions temperate climates are medically important. The purpose of this study was to identify the species diversity of medically important flies in Ghaemshahr city.

This study was a descriptive-analytical survey from June of 2017 to May 2018 was carried out for one year. Plastic bottle traps With reverse span and insect netting were used for Captured flies. The flies were identified by validated keys after mounting.

In this study, eight species of medically important flies including Lucilia sericata (6/2%), Lucilia Ceasar (19/9%), Calliphora vicina (2/6%), Sarcophaga variegata (4/6%), Sarcophaga africa (1/8%), Sarcophaga lehmanni (1/2%), Muscina stabulans (4/6%), and Musca domestica (51%) were hunted from three families of Muscidae (1869 number), Calliphoridae (965 number) and Sarcophagidae (258 number). The highest number of flies captured was in June (15/8%) and July (15/9%) and the lowest was in February (3%) and March (4/4%). Also, the highest number of flies captured were from rural areas (38.6%).

The diversity of flies and their abundance is high especially in June and July in Ghaemshahr city and more precise control measures should be done during this time.

It is currently fulfilling the needs and expectations of patients and providing their satisfaction from the main goals of the organization of health services. Because awareness of patients chr('39') perceptions and expectations plays an important role in providing better and more quality health care services, this study aimed to compare expectations of patients with their perceptions of health care quality among educational hospitals in Neyshabur city using the servqual model.

A recent cross-sectional study was conducted on 271 patients admitted to Hakim hospitals and 22 Bahman Neyshabur hospitals from 2017 to 2018. A Systematic random sampling method and 22-Question SERVQUAL Questionnaire was used to collect data. Data were analyzed by SPSS software ver 17 and using descriptive and inferential statistics (Independent t, Paired t, Pearson correlation, one-way ANOVA).

The results showed that there is a significant difference between the quality of services provided and the expectations and perceptions of patients in all aspects of the five dimensions (p<0.05). The difference between expectation and perception was related to the dimensions of reliability (-6.57) and responsiveness (-5.27) and the lowest gap was related to the dimension of empathy (-2.94).

The quality analysis of services has led to the awareness of authorities in the areas of patient dissatisfaction and the use of procedures and reduces the distance between expectations and perceptions of patients.

Silver nanoparticles are one of the most common nanoparticles used in biomedical applications. They are made by two major chemical and biological methods. The aim of this study was to evaluate the changes of brain tissue due to toxic and non-toxic doses of biological silver nanoparticles in neonatal rats.

This research was an experimental study and 18 male and female Wistar rats were selected and finally divided into 3 groups of 6. One control group and the rest were divided into two equal groups based on toxic and non-toxic nanoparticles. After the pregnancy, the injection was performed in the last two weeks of pregnancy. Two weeks after parturition, histological changes were observed under a microscope in the rats neonateschr('39') brains.

Histological specimens of the group receiving the toxic dose of biological silver nanoparticles show no significant change compared to the control group. Neurons and neuroglial cells had normal features, including clear nuclei and cytoplasm. Their cellular adhesions were also visible around them and no specific changes in neuropilia were observed.

The use of biological silver nanoparticles in non-toxic and toxic doses will not have a detrimental effect on brain and tissue and cell morphological indicators.

Job burnout is one of the main factors in decreasing returns, causing physical and psychological complications in various occupations, especially in nursing. The effects of job burnout sometimes reduce the personchr('39')s willingness to stay in the job. The purpose of this study was to determine the relationship between job burnout and willingness to stay of nurses.

This descriptive-analytical study was performed on 130 nursing staff in psychiatric wards of MUI hospitals selected by simple random sampling. Two questionnaires were used to collect information, Maslach burns out questionnaires and wiener and Vardy questionnaire for willingness to staying in the job. Data were analyzed by SPSS software version 24.

Emotional fatigue (58.46%), depersonalization of personality (44.61%), and inefficiency (43.07%) were calculated at a low level. Most nurses working in psychiatry wards had moderate (43.84%) willingness to stay. Also, the correlation between willingness to stay in the job and emotional exhaustion and depersonalization of personality was inverse and significant (P <0.05). But there was no significant correlation between willingness to stay and inefficiency and job burnout (P <0.05).

The results showed that there is a significant relationship between the dimension of emotional exhaustion and depersonalization with the willingness to stay in the job. By reducing burnout and increasing the willingness of nurses to stay in psychiatry wards, more appropriate services increased job satisfaction, and reduced health care costs can be achieved.
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physical activity has been considered as an effective intervention of prostate cancer treatment strategies by modulating angiogenesis in the tumor. The aim of this study was to investigate the effect of eight-week concurrent training on the plasma and gene expression levels of VEGFR-1 and VEGFR-2 of men with prostate cancer.

In this clinical trial study, 20 men with prostate cancer (age = 62/2 ± 5/69 years old, stage 1 & stage 2) were randomly selected of Baqiyatallah al-Achr('39')zam sub-hospital in Tehran and Patients were divided into two groups of experimental and control. The experimental group performed 8 weeks training including 3 sessions/week. The workouts were the combination of exercises with resistance and endurance training per session as 60-75%, one-repetition maximum, and 60-75% of maximum heart rate. The Blood samples were tested for VEGFR-1 and VEGFR-2 using ELISA and Real-Time PCR methods, respectively, and the data were analyzed using dependent and independent t-test at the significant level p≤0/05.

The results showed that the effect of eight-week concurrent training significantly decreased in BMI (p=0/001) and a significant increase in Vo2peak (p≤0/005) and strength (p≤0/001) the experimental group. Also, significantly decreased plasma levels (p≤0/007) and expression of VEGFR-1 and VEGFR-2 gene (p≤0/03 & p≤0/04) the experimental group compared with control group (P <0.05).

Considering the importance of VEGFR-1 and VEGFR-2 as the main intermediaries of cell signal transduction for angiogenesis and tumor extension, probably the effect of eight-week concurrent training by modifing angiogenesis of tumor microenvironment can be effective in reducing the progression of prostate cancer.

Fertility rate changing population structure. It has a special place in demographic studies. The fertility behaviors of a society can be studied in different ways. One of these methods is to examine the interval between marriage to the first birth. The purpose of this study was to investigate the demographic factors affecting on the interval between marriage to the first birth.

This cross-sectional study was performed on 160 women referred to urban health centers in Esfarayen in 2016. Data were collected using checklists. R3.0.1 software and Cox survival regression were used for data analysis.

In this study, more than 80% of women (130 persons) and 60% of men (97 persons) were under 25 years old age. The mean interval between marriage and first birth was 2.6 ± 1.4 years. There was a significant relationship (p <0.05) between maternal age and education maternal by using the Cox regression model.

In recent years, we have seen an increase in the interval between marriage to first birth, which has resulted in a decrease in the fertility rate. Considering the demographic factors influencing this distance, it is recommended to pay more attention to social and cultural factors in population planning.

Infidelity causes mental health problems, family disruptions, rumination about events, and changes in the betrayed person’s beliefs toward the spouse. So, the purpose of this study was to investigate the effectiveness of "mindfulness-based schema therapy" on depression, anxiety, and hopelessness of women affected by spouse infidelity.

It was semi-experimental research with a pretest-posttest and follow-up ‎control ‎group design‏. The research statistical population comprised all women who required psychological help due to their husband’s betrayal and referred to counseling centers in Mashhad from January to March 2018. A total of 24 women were selected by the available sampling method and were randomly assigned to the experimental and control groups.  Both groups completed Beck depression, anxiety, and hopeless questionnaires in the pretest, posttest, and a two-month follow-up. The experimental group received mindfulness-based schema therapy‎ intervention (Van Vreeswijk et al., 2014) for ten sessions. Factorial repeated measures analysis of variance was used for data analysis.

The effect of the intragroup and intergroup interaction was significant in depression (p=0/01) and anxiety (p=0/001 ) but not significant in hopelessness (p=0/36). There is a significant difference in depression and anxiety from pretest to posttest and follow-up (p <0/01). But regarding hopelessness, the difference between pretest and posttest and follow-up is not significant (p> 0.05).

Mindfulness-based schema therapy can be used to reduce the depression and anxity of women affected by spouse betrayal.