Journal of Obstetrics, Gynecology and Cancer Research
Volume:5 Issue: 1, Winter 2020

Cancer in adolescent and young adults (AYA) includes people who are diagnosed with cancer at the age of 15–39. One of the main concerns and consequences of AYA cancer treatment in both sexes is infertility. Premature ovarian failure (POF) is common in multimodal chemotherapy regimens. There is a significant difference in the sensitivity of the ovary to drugs.In conclusion, in young cancer women, oophoropexy, infertility counseling, and embryo or oocyte cryopreservation should be considered. Medroxyprogesterone, oral contraceptive pill (OCP), or gonadotropin-releasing hormone (GnRH) should be prescribed in the risk of menorrhagia.

In this study, thyroid dysfunction in women with gestational diabetes mellitus was examined and compared to that in healthy pregnant women referred to Kowsar Hospital in Qazvin in 2017 and 2018.

In this case-control study, 100 women with gestational diabetes mellitus and 100 non diabetic healthy pregnant women who referred to Kowsar Hospital in Qazvin from 2017 to 2018 were selected using the convenience sampling method, and their serum thyroxine, anti-TPO, and TSH levels were determined and compared. Moreover, Apgar scores and anthropometric variables were compared between the two groups.

In the present study, there were statistically significant differences between the groups in terms of the TSH level (P=0.012), assessed by the independent t-test, the thyroxine (P=0.0001) and anti-TPO (P=0.008) levels, both examined by the Mann-Whitney test, which associated with high levels of TSH and anti-TPO and low levels of thyroxine in the diabetic group. No differences were found regarding the Apgar scores and anthropometric variables between the groups (P>0.05).

Overall, according to the obtained results, it can be inferred that thyroid dysfunction, realized as hypothyroid with high anti-TPO levels, was more prevalent in women with gestational diabetes mellitus compared to healthy pregnant women.

Vulvovaginal candidiasis (VVC) is a common vaginal yeast infection in women. The present study aimed to determine the phenotype of Candida albicans and non-albicans Candida species in VVC cases.

This was a cross-sectional study on 65 patients suspected of VVC through a visit by a gynecologist. They were cultured on CHROMagar and Sabouraud dextrose agar (SDA). If morphology of the colonies could be detected through microscopic inspection, physiological tests were used to identify individual yeast species.

Out 65 colonies, 53.8% had negative cultures. The frequency of positive cultures for Candida were also calculated (C. albicans = 38.5%, C. glabrata = 6.15%, and C. krusei = 1.53%). Most of culture-negative cases had no history of antibiotic therapy (94.3%) while most of culture-positive cases had a history of fluconazole therapy (56% in C. albicans isolates and 40% in non-C. albicans isolates). Relapse rate was calculated as 29.2%. Of studied patients, 80% had no underlying disease, 15.4% had a history of diabetes, and 4.6% had a history of corticosteroid therapy. Less than half negative-culture cases had an undergraduate degree (45.7%).

The incidence of VVC depends on various factors including occupation, underlying disease and history of antibiotic therapy. The most common cause of VVC is C. glabrata, secondary to C. albicans. Relapse infection rates can be reduced by increasing knowledge on clinical data, underlying diseases, mechanism of the organism, cause of infection, and effective treatment.

Endometrial cancer is the most frequent genitourinary tract malignancy in women. Women with endometrial cancer mostly refer at early stages of the disease which leads to good prognosis. Magnetic resonance imaging (MRI) has a crucial role in staging of the cancer. As there are little studies regarding the correlation between histopathology and International Federation of Gynecology and Obstetrics (FIGO) staging in Iranian women with endometrial cancer, we designed this study to assess the relationship between histopathology and FIGO staging with MRI in Iranian women with endometrial cancer.

This retrospective study was conducted in Imam Khomeini hospital complex between January 2015 and January 2018. All MRIs were performed on a 3T system. All imaging was done in Imam Hospital under observation of attending Radiologists with 10 and 20 years of work experience in women’s imaging who conducted this research. Obtained surgical specimens were assessed by an expert pathologist in the field of cancer and type of cancers were determined.

Thirty two women with proved endometrial cancer (D&C or endometrial biopsy) were enrolled. Mean age was 55.2±10.7 years and all women referred to our clinic with vaginal bleeding. The most common FIGO staging was IA (14, 43.75%) and the most frequent pathology was endometrioid type adenocarcinoma (30, 93.7%) (60% well differentiated, 13.3% moderately differentiated, and 26.6% poorly differentiated). Most cases with endometrioid type poorly differentiated referred with IIIC1 stage of cancer, most patients with endometrioid type well differentiated referred with stage IA, a patient with clear cell cancer referred with stage IIIB, and patients with sarcoma referred with stages IB, and IV.

 Patients with poor differentiated endometrial cancer referred with higher stages of the cancer.

Spontaneous vulvar edema is not usual during pregnancy and can cause discomfort and anxiety for the patient. This is a serious situation that might be caused by some dangerous condition such as preeclampsia, diabetes vulvovaginitis, severe anemia, and neoplasms. The aim of this study was to evaluate and manage the vulvar edema.

Case Report:

 In this case report we introduce a 22-year-old woman which is primigravia and have massive vulvar edema after Bronchitis and influenza at 17 weeks’ gestation. After using oseltamivir, the patient showed progressive edema during 4 hours. Her symptoms were including edema and pain in labia, then she was treated with Dexamethazone and the edema disappeared after 5 days.

Vulvar edema is a critical situation during pregnancy that needs attention and should be treated carefully since it can cause pain and discomfort for the pregnant woman. Our experience in this case was treatment by corticosteroid that had good response.

Conjoined twins (CTs) are rare complications of monozygotic twinning. Cephalothoracopagus is the rarest subtype of CTs and occurs once in every 58 sets of conjoined twins or once in every three million births. Here we present such a case and analyze the possible reasons for ultrasonographic misdiagnosis and recommend solutions to avoid it.

Case Report:

 In this article, we have reported a case of Cephalothoracopagus Janiceps twining. The ultrasonographic diagnosis was missed at 7 and 12 weeks scans. Increased thickness of nuchal translucency and absent nasal bone was observed alongside with suspected gastroschisis. The patient was referred for further evaluation at 13-14 weeks of pregnancy. Unexpectedly, two alive fetuses were reported fused in the head, thorax, and abdomen. Because of the poor prognosis, counseling was provided for parents and elective medical pregnancy termination was carried out. We have analyzed the possible reasons for ultrasonographic misdiagnosis.

Without applying a standardized scanning of the entire uterus both in a longitudinal and transverse approach in early pregnancy, cephalothoracopagus twining may be misdiagnosed with a singleton pregnancy. A high level of concerns may raise for conjoined cephalothoracopagus twinning in case of finding a single fetal pole with an irregular body outline and a disproportionally large head in the presence of two separate fetal hearts in early pregnancy. Two fused heads with two brains and two sets of lower and upper extremities do confirm the diagnosis.