فهرست مطالب

Advanced Biomedical Research
Volume:1 Issue: 1, Jan 1900

  • 1900
  • تاریخ انتشار: 1390/11/25
  • تعداد عناوین: 1
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  • Zoya Tahergorabi, Majid Khazaei Page 79

    Leptin is an endocrine hormone synthesized by adipocytes. It plays a key role in the energy homeostasis in central and peripheral tissues and has additional roles are attributed to it, such as the regulation of reproduction, immune function, bone homeostasis, and angiogenesis. The plasma concentration of leptin significantly increases in obese individuals. In the present review, we give an introduction concerning leptin, its receptors, signaling pathways, and its effect on cardiovascular system, especially on angiogenesis.

    Keywords: Angiogenesis, cardiovascular disease, leptin, leptin resistance