مجله پزشکی دانشگاه علوم پزشکی تبریز
سال چهل و سوم شماره 6 (پیاپی 156، بهمن و اسفند 1400)

The prevalence of chronic kidney disease (CKD) is increasing every year, which increases the risk of cardiovascular disease and even death. In Cardiorenal syndrome type 2 (CRS2), chronic cardiac dysfunction causes renal dysfunction. The aim of this study was to evaluate Doppler ultrasound of renal veins, calculate venous impedance index (VII) and determine their associations with the prognosis of CRS2 syndrome in patients with a history of chronic heart disease and CKD with a good forward function.

In this descriptive-analytical study, 49 patients referred to Imam Reza Hospital in Tabriz with heart failure and renal dysfunction were selected. Renal status, VII and ejection fraction (EF) were evaluated.

Mean age of the patients was 61.83±12.39 years, 42.9% of which were women and 57.1% were men. The durations of heart and renal failure were 33.16 ± 13.8 and 11.76±5.1 months, respectively. Significant associations were found between VII and EF of the right and left kidneys (P=0.01 and P =0.03, respectively). But there was no statistically significant relationship between renal function and EF (P =0.54). With increasing edema rate, both VII and EF were decreased; however, these associations were not statistically significant (P >0.05).

According to the results, significant associations were found between VII and EF of right and left kidneys, however, no statistically significant correlations were observed between edema and VII mean and EF.

Transplantation of chondrocytes is one of the methods for treatment of articular cartilage defects. For this purpose, it is necessary to isolate these chondrocytes and expand in serum containing culture medium. Sera contain growth factors that are added to medium. Fetal bovine serum (FBS) is used for standard cell culture. However bovine proteins of FBS are accompanied with risk of host immune system reactions. Therefore, it is necessary to replace FBS with human serum for clinical cases. In addition, infants have chondrocytes with high proliferation potency versus adults. In this study, the effects of FBS and human placental serum was investigated on morphology and cellular senescence related genes expression of chondrocytes of infants.

Chondrocytes after isolation of from polydactyly cartilage tissue samples, were cultured in 10% FBS and human serum up to passage 5. Human placental serum was obtained from venous blood of embryonic surface of human placenta. Chondrocytes in two culture medium were compared morphologically by inverted microscope. For cellular senescence evaluation, relative expression of IGF1 and P16 genes were assessed by quantitative real-time RT PCR.

Proliferation of chondrocytes is markedly decreased in FBS groups in comparison with human serum. In FBS containing medium, phenotypes of cells were changed from spindle shape to flat appearance after five passages. The expression IGF1 and P16 genes are increased in chondrocytes grown in FBS containing medium and it was significant about P16. Morphologic results were in agreement with Real-time RT PCR results.

Human placental serum has advantages such as high proliferation rate on human chondrocytes, prevention from cellular senescence and immunological problems in using cultured chondrocytes for cartilage tissue engineering.

Clinical and pathologic features of oral and maxillofacial malignant lesions are very important and useful in diagnostic and therapeutic planning. The aim of this study was to determine and compare the clinicopathologic features of different types of oral and maxillofacial cancers in Cancer Registry System at Isfahan-Iran.

In this cross-sectional descriptive analytic study, required data (tumor type, tumor location, age, sex, and grade of malignancy) of 1081 patients from Isfahan Cancer Registry collected.

In this study, the mean age of the patients was 59.9±18.5years old. Most of the patients were male (56.43%). In this study, squamous cell carcinoma was the most common malignancy (61.9%) followed by non-Hodgkin's lymphoma (7%). The most common site was tongue (38.7%) and then the nasopharynx (13%). Also nasopharynx tumors in men were more common than women (P <0.001).

Squamous cell carcinoma, as the most common oral and maxillofacial cancer, requires considerable attention and rapid and appropriate diagnosis and treatment. Knowing the clinical and pathological features of this cancer and risk factors can improve the prognosis of patients.

 Epilepsy is one of the most common neurological disorders after stroke. Due to the side effects and poor response of conventional anticonvulsant drugs, researchers have turned their attention to find new drugs. Carvacrol is a phenolic compound with neuroprotective, anti-inflammatory, antioxidant and anticonvulsant effects. The aim of the study was to investigate the anticonvulsant effects of carvacrol in PTZ-induced seizures in male mice and to investigate the role of N-Methyl-D-Aspartic Acid (NMDA) receptor.

 In the present experimental study, 90 mice were randomly divided into 9 groups (n=10). Drugs were injected intraperitoneally 30 minutes before PTZ injection. Then, seizure onset time, serum and brain antioxidant capacity (TAC) and malondialdehyde (MDA) and NMDA receptor gene expression in the hippocampus were examined.

 Seizure onset time in the group received carvacrol (20 and 40 mg/kg) was significantly longer than the PTZ group (P<0.05). Treatment with carvacrol (20 and 40 mg/kg) significantly increased serum and brain antioxidant capacity and reduced serum and brain MDA in compared to the PTZ group (at doses of 5, 10, 20 and 40 mg/kg). The expression of NR2A and NR2B subunits of hippocampal NMDA receptors in carvacrol-received mice was significantly lower than the PTZ group (P<0.05).

Carvacrol has anticonvulsant effects, possibly by inhibiting oxidative stress and reducing the expression of subunits of NMDA receptors.

 Infertility as one of the bitter and Stressful experiences of couple’s cohabitation can affect various aspects of marital relationships, sexual relations and attitudes toward them. Therefore, the study aimed to determine attitudes of infertile women towards infertility and sexual behavior.

 In descriptive study with cross-sectional And retrospective study, 124 infertile women referred to the infertility center of Al-Zahra Hospital in Tabriz were selected by counting sampling method. The required data were collected through demographic information and sexual attitude questionnaire.

 The 60 percent of participants did not report a change in the quality of their sexual relationships. Also, 63 percent of the participants state that sexual desire has no effect on infertility. Most participants did not blame anyone for their infertility (84%) and patients sexual relationships before and after awareness about infertility were not different.

 The infertility awareness had no effect on patients' sexual relationships. However, patients had problems in control of their lives and were affected by People around.

 One of the important determinants of a successful marriage is the realistic expectation about marriage. This study aimed to assess the expectations of newly married couples about marriage referred to the pre-marital counseling center, and also the factors affecting their marriage expectations. Methods. In this cross-sectional study, to examine the level of marital expectation of newlywed couples referring to the premarital counseling center in Tabriz from August 2018 to April 2019, 284 samples were chosen. The self-administered Marriage Expectation Scale was used to collect data.

 In a sample of 284, the mean age was 26±5 years. Approximately 52% of couples had an academic education. The mean marriage expectation score was 158.13±19.74. According to the results of logistic regression, the odds of idealistic marriage expectation among couples with an academic degree was 2.94 times higher compared to those with an under diploma degree (P= 0.003). In addition, the odds of idealistic marriage expectation among employees and self-employed couples was 3.14 and 3.16 times higher compared to the unemployed ones or housewives, respectively (P<0.05).

 The majority of couples had idealistic expectations about marriage and also couples with academic education, self-employed and employees had more idealistic marriage expectations.

 Neurotrophic factors play an important role in the brain plasticity. The brain developmental processes remarkably occur in the pre-pubertal period, and training interventions during this sensitive period may lead to specific effects. The purpose of this study was to investigate the effects of combined training and activity in an enriched environment on the brain BDNF and VEGF protein levels in the pre-pubertal male rats.

 The pre-pubertal male Wistar rats (n=18) were randomly divided into three groups of combined training (CT), enriched environment (EE), and control (C) at postnatal day 22. The combined training included endurance and resistance physical exercises, which performed six days a week. A large cage with various rich stimuli (wheel running, ladder, toys, tunnels) was provided for voluntary physical activity in an enriched environment. The interventions lasted for three weeks, and the brain tissue (right hemisphere) was removed for biochemical evaluations. The BDNF and VEGF protein levels of the brain were measured by the western blotting method.

Significant differences found in the BDNF and VEGF levels in this study (P<0.01). The neurotrophic factors were significantly increased in the CT and EE groups. Although VEGF protein level increased in both groups, only enriched rats showed a significant difference.

 It can be concluded that combined training and voluntary physical activity in an enriched environment in the pre-pubertal period can effective in brain plasticity by increasing the neurotrophic factors.

Employee job satisfaction is one of the most important issues in any organization. Job satisfaction is described as general attitude of a person towards his job. Job satisfaction of medical assistants increases and promotes the quality of medical services and improves patients' satisfaction with medical services. The aim of this study was to determine the level of job satisfaction and hopelessness of medical assistants in educational centers of Tabriz. In this descriptive-analytical study, medical assistants of Tabriz University of Medical Sciences were selected and assessed using the Job Descriptive Index (JDI) for Job Satisfaction and Beck Hopelessness Scale. Hopelessness decreases with increasing job satisfaction (P<0.001). There was a significant relationship between hopelessness and domesticity (P=0.017) and between job satisfaction and the level of hopelessness with the marital status of assistants (P<0.001) and (P=0.043).