فهرست مطالب

Biological and Biomedical Journal - Volume:7 Issue: 2, Spring 2021
  • Volume:7 Issue: 2, Spring 2021
  • تاریخ انتشار: 1400/10/20
  • تعداد عناوین: 4
|
  • Association between the level of glycosylated hemoglobin and serum lipid profile in patients with type 2 diabetes mellitus
    Jihan Mustafa, Ayad Ahmad* Page 1
    Background

    Diabetes mellitus is a chronic metabolic disorder characterized by defect in insulin secretion and action resulting in hyperglycemia. Diabetic patients have deranged body metabolisms particularly for lipids which may result in abnormal levels of serum levels of lipids.

    Methods

    The aim of this study is to find any possible correlation between the the glycosylated hemoglobin and the lipid profile in patients with type 2 diabetes mellitus in Duhok city. A total number of 235 patients with type 2 diabetes were included.

    Results

    The mean age was 56.19 years, and females constituted 73.2%. The mean duration of diabetes was 101.30 months, and the mean level of HbA1c was 8.0297 %. About 58.30% had good glycemic control, 28.51 % had poor control, and 13.19% had excellent control.
    The mean level of the serum cholesterol was normal (180.63 mg/dl), and the mean level of serum triglycerides were elevated (188.46 mg/dl), the mean level of the LDL was elevated (102.07 mg/dl), and the mean HDL level was normal (47.30 mg/dl).
    There was a significant correlation between the mean level of HbA1c and LDL levels (P value 0.005) while the correlation was not significant for other types of serum lipids such as triglycerides, cholesterol, and HDL (P values 0.879, 0.091, and 0.253) respectively,

    Conclusion

    Elevated glycosylated hemoglobin may be an indicator of derangement of the lipid metabolism and elevated levels of serum lipid profiles which indirectly may indicate high risk factor and as a predictor for increased risk of end stage vascular disease.

    Keywords: Glycosylated hemoglobin, HbA1C, Diabetes mellitus, Lipid profile, LDL
  • Fabry dissase from the dentist view
    Vesna Ambarkova*, Arjeta Sulejmani, Tina Krmzova, Zoran Nonkulovski Page 2

    Fabry disease is a rare, inherited disease with lack of the enzyme alpha-galactosidase A (α-Gal)  in the cells of the body that participates in the breakdown of fat. The disease begins in early childhood, progresses slowly throughout life and results in severe damage of the kidneys, heart and central nervous system. The disease is life-threatening and if left untreated, death occurs in the fourth or fifth decade of life. The development of the disease and the onset of symptoms are entirely individual: they are unpredictable and often depend on hereditary predisposition.
    Very often a child or adult with these symptoms visits 7 to 10 different specialists before being properly diagnosed, although the fact that early diagnosis is the key of successful treatment. Early recognition of a person  with Morbus Fabry is very important, because as soon as patients start to be treated with appropriate therapy the damage of the internal organs is prevented. Enzyme replacement therapy (ERT) as a specific therapy for this disease was introduced in 2001 and is obtained by use of in vitro prepared alpha-galactosidase A. The  interdisciplinary team of dental specialists in collaboration with medical doctors must be included in the dental  treatment of patients with Fabry disease. They have to work together in order to improve oral health-related quality of life of patients with Fabry disease. 

    Keywords: Fabry disease, Oral manifestations, Rare diseases, Interdisciplinary dentistry
  • Fetomaternal outcome in preeclampsia in a tertiary care hospital
    Swati Gurav*, Uma Wankhede Page 3

    Preeclampsia contributes significantly to maternal & perinatal morbidity and mortality.

    Objective

    To study maternal & fetal outcome in preeclampsia.

    Method

    Case records of 168 women with preeclampsia, out of which 58 had severe preeclampsia were analysed. This retrospective observational study was conducted at B.J. government medical college, Pune, during period of 1st March 2020 to 30th June 2020.

    Result

    Incidence of PE was 6.43.  Among study group 70% were primigravida & nearly 70% were >37 weeks of gestation. 15 (8.9%) patients developed eclampsia, 6(3.5%) developed abruptio placentae, 5(2.9%) had HELLP syndrome. PPH was noted in 22% cases. Prematurity, LBW & stillbirth was noted in 54(32%), 59(35%) and 7(4%) cases respectively. 54% Cases delivered by caesarean section. The adverse maternal outcome includes PPH, eclampsia, abruptio placenta, while for fetus prematurity and LBW which increased fetomaternal morbidity in patients of preeclampsia.

    Conclusion

    Although it is not possible to prevent PE & its morbidity, antenatal screening for early detection & timely intervention will help to improve pregnancy outcome.

    Keywords: Preeclampsia, HELLP Syndrome, Eclampsia, maternal morbidity
  • SEROPREVALENCE AND CO- INFECTION OF Toxoplasma gondii AND Hepatitis B Virus AMONG WOMEN OF CHILD-BEARING AGE IN OSUN STATE NIGERIA
    Olarinde Olaniran*, Ayobami Esther Awoyeni, Oluwayemisi, Olanrewaju Olaniran, Patience, Ngozi Adenekan, Daniel Adegoke, Samuel Oladosu Page 4

    This study assessed the seroepidemiology of Toxoplasma gondii, Hepatitis B Virus and their co-infection infection in women of child-bearing age in communities in Osun State, Nigeria. The study also determines the factors that facilitate the organisms among the studied groups and possible interaction between the prevalence of infection and the risk factors. These were done with a view to providing baseline information on the mode of T. gondii and Hepatitis B Virus transmission.
     Sera were analyzed for the presence of IgG and IgM antibodies against T. gondii by commercially available enzyme linked immunosorbent assay (ELISA) kit (Demeditec Diagnostics GmbH, Germany) conducted according to the manufacturer’s instructions. The optical densities of wells were measured by a photometer at a wavelength of 450 nm and the detection of hepatitis B surface antigen (HBsAg) was done using rapid immunochromatographic (IC) tests which are in cassette form. Determination of the blood groups of the donors was done using commercially prepared Anti sera A, B, AB and anti D that determine the Rhesus blood group.
    The overall prevalence of T. gondii among the women of child-bearing age in selected six communities in Osun state was 74.2%, while the overall prevalence of Hepatitis B virus among the women was 4.3% and co-infection of T. gondii and Hepatitis B virus was 3.6%. The prevalence of T. gondii was lowest (57.8%) among women from Ile Ife, a peri-urban community and highest (100%) in women residing in Alajue, a rural community. The prevalence of T. gondii infection was significantly higher (P= 0.001) among Islamic women (85.9%) than in Christian women (68.2%) while the prevalence of Hepatitis B virus (5.0%) and co-infection of T. gondii and Hepatitis B virus (3.8%) was higher among Christianity. The highest prevalence of (83.6%) was recorded in women with primary education while the lowest of (58.7%) was recorded in women with tertiary education (p =0.037). The highest prevalence of T. gondii (78.5%) was recorded in women that reside in rural area and the lowest (67.5%) was recorded in women that reside in peri-urban area (p=0.016) and also the prevalence of Hepatitis B virus (5.9%) and co-infection of T. gondii and Hepatitis B virus (4.6%) was higher in rural area, The highest prevalence of 74.4% of T. gondii was recorded in women with one miscarriage while the lowest value of 73.3% was recorded in women with two miscarriages and the highest prevalence of Hepatitis B Virus infection of 5.7% was recorded in women with one miscarriage while the lowest prevalence of 4.7% was recorded in women with no miscarriage.    
    The highest prevalence of 100.0% of T. gondii and 7.1% of Hepatitis B Virus infection was recorded in women with pregnancy while the lowest of 13.6% and 4.2% was recorded in women without pregnancy for both respectively.
    The study concluded that there was high prevalence of T. gondii infection (74.2%) and also implicates Hepatitis B virus (4.3%) and co-infection of both (3.6%) in the studied population. The high prevalence of T. gondii recorded among women of child-bearing age in the study was highly facilitated by the drinking of water from various sources in the study area. Hence, there is the need for health education and create awareness of the disease and its transmission to women of reproductive age group in general and pregnant women in particular to reduce the risk of T. gondii and Hepatitis B virus in pregnant women.

    Keywords: SEROPREVALENCE, CO- INFECTION, Toxoplasma gondii, Hepatitis B Virus, WOMEN, CHILD-BEARING AGE, NIGERIA