مجله دانشگاه علوم پزشکی تربت حیدریه
سال دهم شماره 1 (بهار 1401)

Changes in the expression of blood-spinal barrier proteins play an important role in the move and development of neuro-inflammatory responses. This study investigated the effect of four weeks of resistance training and date pollen extract on the expression of claudin-5 and connexin-43 proteins in male rats.

30 male Wistar rats randomly divided into 6 groups: Control; Resistance training; DPP extract; Testosterone; DPP extract+ resistance training; Testosterone+ resistance training. The amount of 100 mg/kg date pollen extract was fed to mice by gavage for 4 weeks. Testosterone at a dose of 100 mg/ml was also used subcutaneously in the target group. Resistance training consisted of a four-week increasing training period on a 50-step ladder with 8 to 12 repetitions per session. Data were analyzed using statistical test in SPSS software version 23 at a significance level of 0.05.

Histological staining showed an increase in the amount of lipolysis, a decrease in the number and size of inflammatory cells in the nervous tissue of resistance training, date pollen extract and testosterone groups. Four weeks of resistance training caused a significant increase in the gene expression of claudin-5 (P=0.004) and connexin-43 (P=0.005). Four weeks of receiving DPP extract also had a significant increasing effect on the expression of these genes (P=0.005 and P=0.001). The most significant increase in claudin-5 and connexin-43 was related to resistance training/DPP extract and training/testosterone groups (P<0.05). 

Apparently, four weeks of resistance training and separate testosterone consumption is a suitable approach to increase the expression of blood-spinal barrier proteins, but the separate consumption of DPP extract has better effects. The combination of these interventions will have additional effects in improving the levels of these proteins and maintaining the integrity of the barrier.

One of the most common metabolic diseases is diabetes with hyperglycemic properties and endogenous insulin dysfunction. This study aimed to evaluate the effect of 10 weeks HIIT on HIF-1α gene expression in heart tissue of rats with type 2 diabetes.

In this experimental study, 36 Wister rats with a mean weight of 200±58g were randomly assigned to control, diabetic, and diabetic training groups. The diabetic training group received HIIT 10 weeks after induction of diabetes. Twenty-four hours after the last training session, blood serum samples and heart tissue were collected for analysis. Data were analyzed using a one-way analysis of variance and Tukey post hoc test at a significance level of 0.05%. 

The results of the present study showed that type 2 diabetes significantly reduces the expression of the HIF-1α gene in the heart tissue of mice with type 2 diabetes (P=0.001). However, HIIT significantly increased the expression of the HIF-1α gene in the diabetic group with exercise compared to the diabetic control group (P = 0.001). The results also showed that HIIT training significantly reduced the insulin resistance index in the diabetic group with exercise compared to the diabetic control group (P = 0.001). At 10 weeks, HIIT had no significant effect on the left ventricular weight of heart tissue (P> 0.05).

In general, based on our findings, diabetes appears to significantly reduce the expression of the HIF-1α gene in heart tissue and HIIT may increase insulin sensitivity and protect HIF-1α from their heart tissue.

The use of patient-centered self-management programs may be effective in creating desirable behaviors and improving the lifestyle of the elderly. Therefore, this study was performed to determine the effect of self-management program based on Model 5A on self-care and quality of life in elderly patients with hypertension. 

This randomized controlled clinical trial study was conducted in 1400 with the participation of 60 elderly patients with hypertension who referred to the cardiac clinic of Mashhad Army Hospital. The elderly were selected based on inclusion criteria and then randomly assigned to intervention and control groups (30 people in each group). In the intervention group, a self-management program based on the 5A model was implemented in 5 stages of Assess, Advice, agree, Assist and Arrange over a periodof two months on the elderly with their caregivers. In the control group, routine care was performed. Data were collected using demographic information form and standard questionnaires of self-care behaviors and quality of life SF-36. Data analysis was done using descriptive and inferential statistics with the help of SPSS version 16 software.

The mean and standard deviation of the age of the elderly was 66.2±3.3. The mean and standard deviation of the total self-care score of the elderly after the intervention was 60.8±3.7 in the experimental group and 58.7±5.4 in the control group, which the mean deference between the two groups before and after the intervention was statistically significant (P = 0.01). Also, the mean and standard deviation of the total quality of life score of the elderly after the intervention was 90.9±5.4 in the experimental group and 75.6±4.2 in the control group, which was statistically significant (P<0.001). There was a significant difference between the mean scores of all dimensions of quality of life except general health in the experimental and control groups (P <0.001).

The results of the present study showed that the implementation of selfmanagement program based on 5A model is effective on self-care and quality of life of the elderly with hypertension. It seems that using 5A Model in the health system as an effective intervention can be effective in improving the health status of the elderly.

Considering that recognizing the experiences of professors and students is important in improving the quality of Virtual educationthe present study aims to explain , the understanding and experience of faculty members of Mashhad University of Medical Sciences of virtual education during the covid-19 epidemic. 

This qualitative study was conducted with a content analysis approach atMashhad University of Medical Sciences. B participants were selected from the faculty members of Mashhad University of Medical Sciences through purposive sampling. Semi-structured interviews were used to collect data. Sampling was continued until saturation of the data. Data analysis was performed using the content analysis method. The validity of the data was also confirmed according to Lincoln and Guba criteria.

Data analysis led to the emergence of three main categories: 1. "advantages of Virtual education " With the sub-categories "Reducing economic costs, the flexibility of Virtual education and creating a suitable teaching-learning environment" and 2. "Disadvantages of Virtual education" With the subcategories "Lack of sufficient skills in using virtual training, Insufficient space, facilities and infrastructure, Lack of effective interaction and sufficient motivation, lack of ethics and information security, Impossibility of quality evaluation, Lack of proper software support, Impossibility of assessing proper attendance" and 3. "Virtual education promotion strategies" With the subcategories " Strategies to promote Virtual education in policy and incentive policies, Perform an effective evaluation, improving teaching skills, Combining online and offline training and infrastructure development and technical support" 

Aid, management, and support of Virtual education structures, and promotion of cultural, motivational, and economic infrastructure, can help in the development of designing virtual education environments in universities and achieving educational goals at all levels of education

Spiritual health education for female adolescents improves their quality of life. Family is one of the factors affecting the spiritual health and quality of life of adolescents. The aim of this study was to determine the effect of spiritual health education with family participation on health-related quality of life in female adolescents.

This study was a randomized controlled clinical trial before and after on 60 adolescent girls aged 14-12 years in Mashhad in 1401-1400. Among 22 urban health centers, two centers were selected by simple random method. .Data collection tools include; Demographic information form and quality of life questionnaire related to health Kidscreen 27 that were completed before, immediately and one month after the intervention by both groups. The educational content was held in 8 sessions of 30-45 minutes twice a week for the intervention group. Three training sessions were held for the mothers of this group and the control group received the usual trainings. Data were analyzed using SPSS.24 software and independent t-test, analysis of variance and Mann-Whitney U. 

Before the intervention, the mean total score of health-related quality of life in the two groups was not significantly different (P> 0.05), but after the intervention, the mean total score of health-related quality of life in the intervention group was significantly higher than the control group. Was (P <0.05).

Spiritual health education with the participation of the family increased the quality of health-related life in female adolescents, so the use of these educations is recommended.

Generalized anxiety disorder is one of the common psychiatric disorders characterized by chronic and uncontrollable worry. This research was conducted with the aim of determining the effectiveness of cognitive therapy based on mindfulness on the severity of symptoms and worry in patients with generalized anxiety disorder.

In this research, a quasi-experimental design, pre-test and post-test with a control group was used. The statistical population included all patients with generalized anxiety disorder who referred to psychological clinics in Behshahr city in 2019. A total of 40 patients were randomly assigned to 2 experimental and control groups. The experimental group received 8 sessions of mindfulness-based therapy. The data were collected using standard questionnaires of worry and pervasive anxiety. Univariate covariance analysis and SPSS version 26 software were used for data analysis.

The results showed that mindfulness-based stress reduction therapy has an effect on the severity of symptoms and worry in patients with generalized anxiety disorder. The Eta coefficient for the severity of symptoms and anxiety was 0.63 and 0.31, respectively.

According to the findings of this research, it can be concluded that the stress reduction treatment based on mindfulness is effective in reducing the severity of symptoms and reducing the worry of patients with generalized anxiety disorder, and this treatment can be one of the options. Effective treatment in reducing worry and severity of generalized anxiety disorder symptoms.

Burn injury is an example of damage to a person's health that causes many problems in the patient, including pain and anxiety. The purpose of this study was to determine the correlation between pain and anxiety in burn patients.

In this cross-sectional study, 86 patients with burn injury admitted to Shahid Motahhari hospital, were selected using available sampling. Anxiety and Background pain severity were measured using spielberger state anxiety inventory and visual analog scale In two occasions, with an interval of one week. Data were analyzed by descriptive statistics using Spss version 20.

According to the study, there was no significant statistical correlation between background pain severity and level of anxiety in the first visit (p=0.609, r=0.056), but in the second visit, a significant relationship was observed between these two variables (p=0.002, r=0.334). 

According to the results of this study, anxiety and background pain are the main factors affecting burn patients and there is a significant relationship between these two. So, assessment and treatment of background pain and anxiety are essential elements of management in burn patients.

Background & Financing of the health system one is one of the four main functions of the health system. It is useful to use the capacity and resources of charities for this purpose. The purpose of this research is to identify and design the financing model of the health system based on the efforts of donors.
This study is a mixed type of research. First the components were identified using the qualitative content analysis method and then the relationships between these components were determined using the structural interpretive modeling method. Finally, by using MICMAC analysis, the type of components was determined according to the impact and effectiveness on other components. The studied population in both quantitative and qualitative sections included senior managers of medical sciences universities across the country, university professors and health benefactors. In the end, 9 experts were selected to conduct the interview by purposive sampling method.
After analyzing the data obtained from interviews with experts, 13 components were identified, which were classified into five different levels and were plotted according to the ISM graph relationships.
According to the results of the MICMAC analysis, the components of building trust among donors, lack of government resources, legal restrictions and the economic status of the society have the greatest effect on other components, and at the same time they accept the least effect from them, it is necessary to examine these components in priority be placed.