فهرست مطالب

Reports of Radiotherapy and Oncology
Volume:8 Issue: 1, Dec 2021

  • تاریخ انتشار: 1401/05/17
  • تعداد عناوین: 6
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  • AmirHoooshang Mohammadpoor, Kamran Ghaffarzadegan, Mehri Hasanpoor, Azra Izanloo, Soghra Mehri, Mahdi Jannati Page 1
    Background

    One of the current challenges in cancer management is finding diagnostic and prognostic markers for various cancers. CXCL10 is a small protein that is defined as an ‘inflammatory’ chemokine and binds to CXCR3 to mediate immune responses through the activation and recruitment of leukocytes such as T cells, eosinophils, monocytes and natural killer cells. It facilitates the immune system antitumor activity, and causes tumor regression through induction of angiostasis and cellular apoptosis. Most previous studies have reported the anti-tumor activity of CXCR10, while studies on its role in colorectal cancer are limited.

    Objectives

    The present study aimed to evaluate the correlation of serum CXCL10 level with the prognosis of patients with colorectal cancer.

    Methods

    This retrospective cohort study was performed on 69 patients with a histopathological diagnosis of colorectal cancer in the oncology ward of Razavi Hospital, Mashhad, Iran, between July 2018 and September 2019. The relationship between the serum CXCL10 concentration and colorectal cancer prognosis was investigated.

    Results

    The results of Cox regression analysis indicated a significant relationship between the patients’ mortality and metastasis rate and a high concentration of CXCL10 (P = 0.018 and P = 0.045, respectively); however, a high concentration of CXCL10 was not significantly correlated with the recurrence rate (P = 0.81) during the four-year follow-up.

    Conclusions

    The level of CXCL10 was significantly associated with incidence of mortality and metastasis in colorectal cancer patients during a four-year follow-up.

    Keywords: Survival, Prognosis, CXCR3, CXCL10, Colorectal Cancer
  • Adi Muradi Muhar, Muhammad Nuh Alhudawy, Dedy Hermansyah *, Desiree Anggia Paramita, Naufal Nandita Firsty Page 2
    Context

    According to the World Health Organization, colorectal cancer (CRC) is the third most prevalent cancer globally, with the highest mortality rate after lung cancer. Some studies predicted risk factors provoking CRC recurrence. However, no single study discussed CRC recurrence.

    Objectives

    This study aimed to quantitatively estimate the influence of several risk factors toward early recurrence of CRC.

    Methods

    We utilized four medical databases, including Pubmed, Cochrane, Wiley library, and ScienceDirect, and a range of literature searches between July to October 2020 with output study, odds ratio (OR), and some risk factors. We used PRISMA protocol along with several relevant keywords with NOS method was utilized to assess the quality of the study. Fixed- and randomized effect model were utilized to control each numerical analysis’ bias.

    Results

    We found six studies that compared the risk factor of CRC recurrence after curative resection with curative-intention encompassing a total of 15.457 patients. We found seven risk factors of colorectal cancer recurrence, including vascular invasion (OR 2.3; IK95%: 01.56 - 3.4; P < 0.0001), depth of invasion (T stage) (OR 2.27; IK95%: 1.14 - 4.51; P = 0.02), pre-operative CEA serum (OR 2.24 95 %IK: 1.57 - 3.2; P < 0.0001), post-operative CEA serum (OR 5.97 IK95% : 3.04 - 11.74; P < 0,0001), pre-operative CA19-9 serum (OR 3.03; IK95%: 1.74 - 5.25; P < 0.0001), and regional nodal metastasis (N stage) (OR 2.56; IK95% 1.41 - 4.62; P = 0.002).

    Conclusions

    Risk factors of earlier CRC recurrence were diversely reviewed. The elevation of post-operative CEA serum was assumed as the main factor in this study; however, most of the studied parameters were statistically significant.

    Keywords: Surgical Resection, Recurrence Factors, Colorectal Cancer
  • Yukihiro Hama *, Etsuko Tate Page 3
    Introduction

    The prognosis of recurrent pancreatic cancer is poor even after curative resection. There have been no reports of MRI-guided radiation therapy for locally recurrent pancreatic cancer after curative resection and chemotherapy.

    Case Presentation

    A 66-year-old man with pancreatic cancer was referred to our institution for local recurrence after failure of surgical resection and second-line chemotherapy. He did not want to undergo further chemotherapy, so high-dose MRI-guided adaptive radiation therapy was performed in daily doses of 2.5 Gy to a total dose of 70 Gy over a period of 5.5 weeks. Three months after radiation therapy, the recurrent tumors disappeared and his CA19-9 level was within normal range without chemotherapy. There were no adverse events during treatment and three months of follow-up.

    Conclusions

    High-dose MRI-guided adaptive radiation therapy may be safe and useful for locally recurrent pancreatic cancer.

    Keywords: Pancreas, Neoplasms, Radiotherapy
  • Elham Zarei *, Kazem Anvari, Soudeh Arastouei, AmirHossein Jafarian Page 4

    Atypical teratoid/rhabdoid tumor (AT/RT) is a very rare tumor, mostly found in the posterior fossa of children aged under three years. Combined modality treatment appears to improve the results. Herein, this report aimed to present a case of intramedullary intradural AT/RT of the anterior thecal sac in a 17-year-old girl with subtotal resection by undergoing adjuvant radiotherapy and sequential chemotherapy.

    Keywords: Adult, Oncology, ATRT, Atypical Teratoid, Rhabdoid Tumor
  • Mahmoudreza Kalantari, Shakiba Kalantari, MohammadReza Majidi, Houshang Rafatpanah Baygi, Sare Hosseini *, Seyed Alireza Javadinia Page 5
    Background

     The northeast of Iran is one of the endemic regions of human T-cell lymphotropic virus type-1 (HTLV-1). This study aimed to evaluate the relationship between nasopharyngeal carcinoma and HTLV-1 infection in northeast Iran, an endemic area for HTLV-1.

    Methods

     In this case-control study, paraffin-embedded nasopharyngeal tissue samples of patients with definitive nasopharyngeal carcinoma were evaluated for the presence of the HTLV-1 genome by polymerase chain reaction retrospectively.

    Results

     Thirty patients with nasopharyngeal carcinoma and 30 healthy people were evaluated. All participants were matched in terms of age and gender, and all were living in Mashhad. The HTLV-1 genome was detected in only one of the people in the healthy group.

    Conclusions

     The HTLV-1 infection and nasopharyngeal carcinoma did not correlate significantly.

    Keywords: HTLV-1, Nasopharyngeal Carcinoma Polymerase, Chain Reaction
  • Saeed Solooki, Yaser Mansoori, MohammadHadi Gerami *, Seyed Arman Moein, Jamshid Jamali Page 6
    Background

     Osteosarcoma is a primary and malignant bone tumor. Currently, using neoadjuvant chemotherapy, surgery, and appropriate adjuvant chemotherapy, long-term survival of more than 70% can be expected for patients affected by this disease. Therefore, the combination of different treatment methods increases the chances of saving the limb.

    Objectives

     In this study we intend to share our 10-year experience in the management of osteosarcoma in Shiraz as the referral center of south of Iran.

    Methods

     In this retrospective cohort study, 56 patients with osteosarcoma who were referred to Chamran and Namazi hospitals between 2008 and 2017, were included. Age, sex, site of involvement, presence of metastasis, treatment procedure, treatment outcomes, and survival time were studied. Kaplan-Meier method was used for survival analysis. Log rank test was applied for comparison of survival time according to sex. SPSS software version 25 (SPSS Inc., Chicago, US) was used for statistical analysis. Significance level considered P-value less than 0.05.

    Results

     Among these patients, 33 were men 23 were women, with an average of 10 to 68 years old. In our study, distal femur was the most common site for osteosarcoma. Moreover, 44.6% of the patients undergone amputation. The best treatment results are in patients who received neoadjuvant chemotherapy followed by surgery. Finally, 77% of patients had a 2-year survival rate, and 57% had a 5-year survival rate.

    Conclusions

     There has been a significant advancement in the treatment of osteosarcoma. A multifaceted approach to this disease, including surgery and chemotherapy has increased the possibility of better prognosis for this disease. Early diagnosis and appropriate treatment in the form of neoadjuvant chemotherapy, surgery with appropriate margin removal, and adjuvant chemotherapy are suggested for this tumor.

    Keywords: Osteosarcoma, Outcome, Survival, Chemotherapy, Iran