نشریه دانشگاه علوم پزشکی خراسان شمالی
سال چهاردهم شماره 2 (تابستان 1401)

Colon cancer is known as one of the most current cancers in the world and Iran that high percentage of deadly caners in the world is related to colon cancer. The use of new method to treat and control of colon cancer in developed societies are on rise. Ozone is used as the new and effective method to treat of different diseases, infections and scars. In this study, the effects of different doses of ozone were investigated on the expression of HIF-I and β-catenin genes in the colon tissue of mice with colon cancer.

This study was performed on 35 male Balb/c mice in 5 groups. One group was randomly considered as healthy group and in the rest of the mice colon cancer was induced using Azoxymethane/dextran sodium sulfate (AOM-DSS). One group was not treated and the other three groups were treated with 10, 20 and 40 μg/ml doses of O3, respectively. Then colon tissue was prepared and the change of the expression in HIF-I and β-catenin genes was investigated using Real-time PCR.

Treatment with AOM-DSS dramatically increased the expression of HIF-I and β-catenin genes in comparison to the healthy group (P < 0.001), while ozone decreased the expression of these genes in a dose-dependent manner (P < 0.001).

Ozone in a specific dose has a therapeutic effect on colon cancer and can be used as a substantial method for colon cancer treatment.

Death from cardiovascular diseases is one of the leading causes of death in the elderly; Although the role of exercise and herbs in heart health has been reported, their cellular-molecular mechanisms are not yet well understood. Therefore, the aim of the present study was to investigate the effect of eight weeks of continuous exercise with moderate intensity and intense periodicity along with spring orange (Ca) consumption on some markers of mitochondrial biogenesis in the heart tissue of elderly rats.

In this experimental study, 49 elderly female rats (18-16 months old, weighing 280-320 g) were randomly assigned to (1) control, (2) sham (orange spring solvent), (3) Orange Spring, (4) Continuous Exercise, (5) Periodic Exercise, (6) Continuous Exercise + Orange Spring and (7) Periodic Exercise + Orange Spring were divided. Periodic exercises were performed with an intensity of 85-110% VO2max and a speed of 31-45 m / min and moderate-intensity continuous training (MICT) exercises with an intensity of 65% VO2max at a speed of 25-25 m / min; Orange spring consumption was 300 mg / kg / day peritoneally. Expression levels of peroxisome proliferator-activated receptor-gamma coactivator (PGC-1α), sirtoin 1 (SIRT1) and sirtoin 3 (SIRT3) were measured in cardiac tissue. One-way analysis of variance with Tukey post hoc test was used to analyze the results (P≤0.05).

There was a significant difference in the values of PGC-1α, SIRT1 and SIRT3 in the study groups (P ≤ 0.05). The expression levels of cardiac PGC-1α and SIRT1 in the continuous, intermittent and orange spring exercise groups were not significantly different from the control group. But in the periodic training group, SIRT3 levels were significantly higher than the sham group (P ≤ 0.05). Also, the levels of PGC-1α, SIRT1 and SIRT3 in the groups of continuous training + spring orange and periodic training + spring orange were significantly higher than the control group (P ≤ 0.05). Increased expression of PGC-1α in the combined group of continuous exercise + spring orange was more favorable than the other groups. However, the increase in SIRT3 in exercise groups, especially periodic exercise, was more than other groups (P ≤ 0.05).

Periodic and continuous exercise with orange spring extract seems to improve mitochondrial biogenesis in the heart tissue of elderly rats.

Lepidium draba L (L. draba) is one of the most valuable medicinal plants belonging to the nightshade family. This study was designed to evaluate anxiolytic effects of different doses of the methanolic extract of L. draba and also the role of benzodiazepine receptors.

In this study, 48 male mice weighing 25-30 g were used. The selected mice were randomly divided into 6 groups of 8. To evaluate the anxiolytic effects of methanolic extract of L. draba (50, 100 and 200 mg/kg), saline with equal volume as negative control, diazepam (2 mg/kg) as positive control and flumazenil (2 mg/kg) with high dose of extract was injected into mice to investigate the possible mechanism of the plant's anxiolytic effects, after 30 minutes they were transferred to elevated plus maze and for 5 minutes the standard indicators of anxiety assessment were observed and recorded by observing them. Instat software was used to analyze the data. The results were reported as (Mean ± SEM) and P <0.05 was considered significant.

The results showed that methanolic extract of plant increased the number of entry and length of stay in the open arms in a dose-dependent manner.

This study shows that L. draba plant can be effective in treating anxiety probably through GABAergic system.

Anxiety is one of the most common psychological reactions in patients waiting for surgery, and they usually experience a certain level of anxiety. Aromatherapy is a complementary treatment in which inhaling the scent can shift the autonomic balance towards parasympathetic superiority and calm the person. This review study aimed to evaluate the results of clinical trials on the effect of Lavender inhalation on anxiety and pain in patients undergoing surgery.

This systematic review examined articles published between March 2012 and June 2021. Internal databases, including SID and Magiran, also used external scientific resource databases such as PubMed, Web of Science, Medlib, Science Direct, and Google scholar search engine to collect articles and to search for the keywords Lavender, Surgery, Anxiety, pain, and Aromatherapy in Persian and English sources were used. After evaluating the inclusion criteria and quality of articles, 21 studies were recognized as eligible and included in the present study.

The results of previous studies show that Lavender is very effective in reducing pain and anxiety in patients undergoing various surgeries and can be effective in reducing the usage of pre-and postoperative analgesics and their complications.

According to the studies, inhaling Lavender essential oil can reduce the anxiety and pain of patients undergoing surgery.

North Khorasan province has experienced fertility decline and negative population growth during the last decade. Attitude towards value of children is one of the main determining drivers of fertility.

The research method was cross-sectional survey. The sample size was 166 married women aged 15-49 that were selected by multistage sampling method. Data collection instrument was a questionnaire that was completed through face to face interview. The SPSS software was also used for data analysis.

Findings indicated significantly negative relationships between age at marriage, education and gender attitudes and a positive relationship between religiosity and attitudes toward value of children. Turkmens have a stronger attitude toward value of children than other ethnic groups. The results of path analysis indicate that the women's attitudes toward value of children was improved by religiosity and the weakened by higher education, higher age at marriage and modern gender attitudes.

The results showed that education along with the level of religiosity are important determinants of attitudes toward value of children. Therefore, strengthen of religiosity and develop appropriate supportive programs to combine work and child for educated women are necessary.

The purpose of the current research was to explain the healthy lifestyle with an emphasis on the sports activities of the elderly in the country based on the data theory of the foundation.

The current study is a prospective qualitative applied study based on the foundational data theory, and in terms of data analysis method of analytical-exploratory type and data collection was done in the field. The statistical population of the research included all scientific and experimental experts with a history of research and work in the field of the elderly. The statistical sample was selected as a snowball in 2019, which finally led to the theoretical saturation of the data by interviewing 15 people, which was the final sample considered. Data collection was done through semi-structured and exploratory interviews with experts. To analyze the data, the foundational data theory analysis method (Strauss and Corbin) was used.

The findings showed that the concepts obtained from the coding of symptoms were divided into the main categories, causal conditions, background conditions, intervening conditions, strategies, and consequences of a healthy lifestyle with an emphasis on sports activities of the elderly in the country.

Sports managers of the country can use the obtained model to institutionalize a healthy lifestyle by emphasizing the sports activities of the elderly.

The aim of the present study is identification and prioritizing consequences and strategies of effective crisis management in Iranian sports stadiums.

The research method was mixed. The qualitative data collection tool was through in-depth interviews. After conducting19 interviews with experts, the codes reached theoretical saturation. Data analysis was performed simultaneously using the Strauss-Corbin approach. By performing a three-step coding process (open, axial, and selective), 254 non-repetitive initial codes were obtained, which were classified into 21 concepts and 15 categories. Then, these indicators were provided to the research samples in a hierarchical analysis questionnaire and the factors identified by Expert Choice software based on a method AHP Were analyzed.

It can be said that effective crisis management strategies in Iranian sports stadiums are based on nine categories. Also, the consequences of effective crisis management in Iranian sports stadiums are based on six categories. Finally, the results of prioritization indicated that the factors of effective crisis management in Iranian sports stadiums according to experts in the strategies: safety strategies with a weight of 0.124 in the first place and social strategies with a weight of 0.76 in the last rank has it. Also in the consequences: security consequences with a weight of 0.148 in the first rank and social consequences with a weight of 0.101 in the last rank.

According to the obtained results, it is suggested that sports managers, in addition to empowering staff and related stakeholders such as athletes and coaches, pay special attention to strengthening the safety and security of the physical infrastructure of sports stadiums through training.

In this study, the combined effects of low frequency stimulation (LFS) and carbamazepine (CBZ) were investigated on the motor behavior and balance indices of adult male rats during dorsal hippocampal epilepsy by electrical kindling method.

In this experimental study, 56 adult male Wistar rats were randomly divided into 8 groups. Kindling stimulations were performed rapidly in the dorsal hippocampus. In other groups, carbamazepine was injected before kindling. LFS stimulation was also performed immediately after kindling in the target groups. The animals' motor behavior and balance indices were measured using open field and rotating bar tests. Behavioral data analysis was performed using analysis of variance and Kruskal-Wallis tests.

The results showed that the ability to maintain balance in the rotating rod test in the CBZ20+K+LFS and CBZ40+K+LFS groups had a significant increase compared to the Kindle and K+LFS groups. Analysis of the motor behavior of Kindley mice showed that the search behavior of the drug and LFS groups has significantly increased compared to the K+LFS and K groups. Also, in the study of bipedal standing index, the combined groups showed a significant decrease compared to K+LFS and drug-receiving groups.

The duration of balance on the rotating bar in the drug and LFS groups showed a significant increase compared to the Kindle and K+LFS groups (P <0.05). Comparison of the mean number of bipedal standing indices indicated significant decrease in the drug and LFS groups compared to the Kindle and K+LFS groups (P <0.05).

Considering the suicide is one of the most important public health issues, the present study investigates the comparison between comparison of the effectiveness of two therapeutic approaches Integrative and Acceptance and Commitment Therapy ACT on integrative self- knowledge among people with suicide attempts.

The current research is a quasi-experimental with pre-experimental-post-experimental study with a follow up design. The statistical population of the present study included all people with suicide attempts in North Khorasan who were hospitalized in 2020. The sample of the study included 24 subjects who selected through random sampling as well as inclusion criteria and assigned randomly into two experimental groups (12 people in each group). ACT package and integrated treatment protocol accomplished in eight 90-minutes sessions individually every week. The research tool was Integrative self- knowledge scale Ghorbani et al. (2008). Data were collected in four stages before the intervention, fourth session, at the end of the intervention and after two months. Data were analyzed using of mixed multivariate variance and by SPSS-26 software.

The results showed that both treatments effect on integrative self- knowledge (F = 120.346, P < 0.001, eta = 0.860). In Experiential self- awareness and to integrate there isn’t significant difference between the two treatments but in Reflective self- knowledge integrated treatment was more effective.

In order to increase the level of integrative self-knowledge in people with suicide attempts, more attention should be paid to the use of integrated approach treatment and acceptance and commitment therapy.

The present study aimed to compare the effectiveness of emotional intelligence interventions, sexual fantasies, and integrated protocol in treating the orgasmic disorder, performance, and quality of sexual life.

The type of study is quasi-experimental based on the pretest-posttest design. The study population consisted of all married women aged 30-45 years who had a marital life experience for at least one year and had an orgasmic disorder. The sample consisted of 30 women with a definite diagnosis of the orgasmic disease. The research instruments included Female Sexual Function Index (FSFI), Wilson Sexual Fantasy Questionnaire (WSFQ), Shot Emotional Intelligence Scale, and Perceived Relationship Quality Scale (PRQC).

The results indicated that the effectiveness of all three interventions, including Emotional intelligence, sexual fantasy, and integrated intervention, were adequate for sexual function, quality of the sexual relationship, and orgasm (F =7.36, P <0.001, square share=0.46). The integrated intervention and sexual fantasy intervention were more effective in improving sexual function and quality of individuals’ sexual life than the emotional intelligence intervention. There was no significant difference between the three types of interventions in the orgasm subscale.

The findings indicated that the integrated intervention is more effective than the other two because this type of intervention works both at the cognitive (sexual fantasies) and emotional levels (emotion regulation and emotional intelligence). The results of the present study can be used in counseling and psychotherapy, especially couple therapy and sex therapy, as well as improving marital life and the quality of sexual life.

Cadmium chloride causes hepatic dysfunction. In the present study, the protective effects of hydroalcoholic extract of Alcea rosea aerial parts were investigated on the hepatic enzyme dysfunction induced by cadmium chloride in adult male rats.

In this experimental study, 54 adult male Wistar rats were divided into six groups of 9 as follows; control group, sham group 1 received 0.2 ml/kg distilled water as a solvent, sham group 2 received 2 mg/kg cadmium chloride intraperitoneally for 21 days, and experimental groups 1, 2 and 3 received 2 mg/kg/day cadmium chloride intraperitoneally for 21 days and then respectively 150, 300 and 450 mg/kg hydroalcoholic extracts of aerial parts of Alcea rosea intraperitoneally for 30 days. At the end of the experiment, blood samples were taken from all animals to measure the levels of Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP), Gamma-Glutamyl Transferase (GGT) and Lactate Dehydrogenase (LDH).

Mean serum concentrations of ALT, AST, LDH, and GGT in all experimental groups showed a significant decrease compared to the sham group 2. The mean serum concentrations of ALP in experimental groups 2 and 3 significantly decreased compared to the sham group 2 (P < 0.05).

The hydroalcoholic extract of the aerial parts of Alcea rosea probably modifies hepatic enzyme dysfunction induced by cadmium chloride in male rats.

Despite recent advances in the prevention of parasitic diseases, pediculosis is still one of the most common problems in Iran. This study was designed to determine the effect of parenting education based on self-efficacy theory on preventative behaviors of Pediculosis infection in female students in Mashhad, Iran.

This quasi-experimental study was conducted on the parents of sixty first-grade girl students who entered the study through cluster random sampling. Parents were randomly divided into experimental and control groups. The instruments used in this study were the Pediculosis Infection Preventive Behaviors Questionnaire and Scherer's General Self-Efficacy Questionnaire. The educational intervention was designed based on the theory of self-efficacy and was performed in four sessions of forty-five minutes. Questionnaires were completed before the intervention, immediately after the educational intervention, and three months after the intervention. Data were analyzed using SPSS software version 24 and chi-square, independent and paired t-tests, Mann-Whitney and repeated data analysis.

Before the intervention, there was no statistically significant difference between the mean score of self-efficacy and preventive behaviors of pediculosis infection (P > 0.05), but immediately after the intervention, the mean score of self-efficacy and the score of preventive behaviors showed a significant difference from before intervention (P < 0.05).

The results showed that the design and implementation of educational interventions based on self-efficacy theory increased students' preventive behaviors against pediculosis.