Moclobemide (MCB) is an antidepressant that is metabolized in the liver and acts as a monoamine oxidase inhibitor. The aim of this study was to evaluate the effect of MCB on serum levels of hepatic transaminases, blood biochemical parameters and histopathological changes of liver in adult male rats.

Thirty two adult male Wistar rats were divided into 4 groups of 8. The control group did not receive any treatment, but the experimental groups (Exp) 1, 2 and 3 received doses of 160, 320 and 640 mg/kg MCB as oral gavage for 28 days, respectively. At the end of the study, body weight, liver weight, serum levels of liver transaminases (ALT, AST) and blood biochemical parameters (ALP, total protein, Albumin, total and direct Bilirubin) were measured. Also, liver tissue was removed for histopathological examination.

The results of the study showed that body weight, liver weight and serum levels of total and direct Bilirubin in the experimental groups were not significantly different from the control group (p<0.05). Serum levels of ALT, AST and ALP in Exp1 group did not show a significant difference with the control group (p>0.05) but in contrast, in Exp2 and Exp3 groups, a significant increase was observed (p<0.05). Serum levels of total protein and Albumin in Exp1 and Exp2 groups did not show a significant difference with the control group (p<0.05) but in contrast, in Exp3 groups, there was a significant decrease (p<0.05). In all 3 Exp groups, some degrees of necrosis and destruction of liver tissue were observed, and the maximum necrosis and destruction was observed at the maximum dose.

Moclobemide causes changes in serum levels of hepatic transaminases, blood biochemical parameters and the destruction of liver tissue, especially at the maximum dose (640 mg/kg) in male rats.

Oryctolagus cuniculus are an excellent model for cardiovascular research because the size of these animals is more suitable for study and experimentation than smaller animals and are economical and cost-effective in research. One of the most important diagnostic imaging techniques is echocardiography, which is used today to perform anatomical and functional evaluation of the cardiovascular system and is one of the most accurate and sensitive non-invasive methods for examining heart diseases. Ventricular function indices could be assessed by cardiac imaging techniques. One of these important cardiac parameters is the ejection fraction, which has a valuable position along with other involved parameters. Ejection fraction is a measure of blood percentage that comes out of the heart with each contraction.

For this study, 100 six-month to one-year adult, standard and young Oryctolagus Cuniculus (in Iran) and in healthy   appearance of both sexes (50 female rabbits and 50 male rabbits) were studied without anesthesia and sedation.

In this study, the mean ejection fraction in the studied Oryctolagus cuniculus was 58.753±6.889 in male animals and 61.397±6.530 in females which indicates that the ejection fraction in the assessed male population was significantly higher than the female population.

The measured ejection fraction values were comparable to those mentioned in the authoritative books and there is no significant difference in the average size of ejection fraction measured in this study with the previous research.

producing chickens with high weigh in a short time is the main purpose of the broiler chickens’ producers. This rapid body weight gain can cause some disorders in some organs performs like cardiovascular system and it can make these chickens prone to some diseases like cardiovascular failures as well as the sudden death syndrome. So in this study, it was decided to investigate the growth of aorta and its coordination with body gain in broilers and layer chickens.

Study was performed on Cobb 500 and Ross 380 as broiler chickens and Leghorn as layer chickens and samples were separated from the descending aorta. after tissue processing and Hematoxylin and eosin (H&E) staining, lumen diameter and the thickness of tunica intima, media and adventitia were measured and compared.

The results showed that in broiler and layer chickens, the tunica media was the thickest layer. This layer showed a decrease in thickness on day 40. On the other hand, on day 40, the broiler chickens revealed more weight compared to the layer chickens, and this weight gain happened very fast, while the growth of vessels, the thickness of the layers, and the aortic diameter in both breeds were almost equal.

Thus it can be concluded that with the rapid growth in broiler chickens, birds with smaller cardiovascular and respiratory tracts are formed that it can make them prone to the cardiovascular diseases.

In order to diagnosis of composition, distribution and abundance of Macrobenthic invertebrates’ fauna of Hajati Spring at Kezerun, Fars south-west of Iran, benthic sampling was conducted from March, 2018 to February, 2019.

The samples were collected from five different stations along the river. Three phyla of macrobenthic invertebrates were encountered in the river.

They were Arthropoda, represented by eight genera, Chironomus sp., Tipula sp. and Odontomiya sp. (Diptera), Epitheca sp.(Odonata), Centroptilum sp. (Ephemeroptera), Hydrobius sp. and Hydrochara sp. (Coleoptera); Annelida represented by one genera, Uncinais sp. (Haplotaxida) and Mollusca represented by one genera including Melanopsis sp.( Sorbeoconcha), Arthropoda dominated the macrobenthic invertebrates with a abundance of 65.6% while Annelida had the least abundance, 6.4% by number. The abundance of Mollusca was 28% by number. Also the abundance and diversity of Arthropoda was more than Mollusca and Annelida.

One-way ANOVA showed that there was a significant relationship between collected samples and seasons (P<0.05) while such a relationship was not established between collected samples and stations (P>0.05).

Bone tumors can be benign or malignant and primary or secondary in dogs. Osteosarcoma (OS) is considered the most common primary bone neoplasm in dogs, which has high metastasis ability.

A retrospective histopathological study was performed over cases submitted to veterinary hospitals and clinics in Shiraz, the capital city of Fars province, south of Iran. Surgery and necropsy files of dogs submitted to clinics between 2010 and 2021 were retrospectively studied and cases suspected to bone tumors by were separated.

A total of 872 necropsy and surgical resection specimens from dogs referred to these clinics because of musculoskeletal defects were reviewed during this period, of which, nine dogs (six male and three female dogs) corresponded to bone tumors.

All of the tumors were diagnosed as osteosarcoma. The epidemiological and pathological findings of these tumors are reported.

Today, cow's milk is one of the most important and widely consumed animal milks by humans and a unique source of food for all ages. The contamination of milk with heavy metals such as lead, mercury and cadmium is considered as a danger to humans. Heavy metal poisoning has adverse effects on humans that is much more common in childhood. This study was conducted to evaluate the levels of lead, mercury and cadmium in raw milk in Marvdasht.

In this study, 30 samples of raw cow milk were collected from milk collection centers in Marvdasht and tested for residual heavy metals such as lead, mercury and cadmium using Atomic Absorption Spectrophotometry.

It was found that the average level of lead was equal to 0.01217 and for cadmium was 0.1340 and mercury was 0.0050 in the samples, which according to the standard level of lead, mercury and cadmium in milk in the codex, it indicates that the average accumulated concentration of lead metals in all samples was within the standard range, but the average concentration of cadmium and mercury indicates that the average concentration exceeds the standard limit.

Measurements of the samples showed that the level of lead was lower and the level of mercury and cadmium was higher than the global standard, so in order to increase the health and food safety for consumers, considering more monitoring, including the city’s livestock feed, water consumption, forage cultivation and controlling the pollutants emitted from industrial centers adjacent to livestock are recommended.