فهرست مطالب

  • Volume:11 Issue: 1, Winter 2023
  • تاریخ انتشار: 1402/02/14
  • تعداد عناوین: 8
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  • Paria Habibollahi, Masoumeh Poureskandari*, Mahsa Makouie, Hasan Amiri, Orhan Delice, Aylar Rahimi Page 1
    Introduction

     Tramadol is a unique opioid and the most prescribed opioid worldwide. Tramadol-related overdose and death have been increased in several countries. Due to the high level of tramadol use, misuse, and overdose in Iran, and considering the cost and time spent doing laboratory tests for all patients, this study aimed to investigate the possible relationship between changes in laboratory findings of patients poisoned by tramadol and their neurological manifestations to evaluate the need for these tests.

    Methods

     This was a cross-sectional descriptive study of patients with acute tramadol poisoning who were referred to the Emergency department of Sina hospital, Tabriz, Iran from March 2020 to March 2021. Lab tests taken from the patient in the emergency department were recorded. Meanwhile, the patients’ neurological symptoms were noted. And demographic information of patients was collected in a predesigned checklist and was analyzed by IBM® SPSS® 20.0 release software.

    Results

     A total of 95 patients including 76.8% male and 23.2% female with an average age of 28.26±10.57 were admitted to the emergency department. The most common symptoms of neurological impairment experienced by patients were seizure (32.6%) and decreased level of consciousness (38.8%). There was no relationship between the neurological symptoms of tramadol poisoning with neither arterial blood gas characteristics nor hematological factors (P>0.05).

    Conclusion

     The neurological manifestations of tramadol poisoning were not related to arterial blood gas characteristics such as PH, PCO2, PO2, and HCO3−. Also, there was no relationship between hematological factors including white blood cell (WBC), red cell distribution width (RDW), platelets (Plt), sodium (Na), potassium (K) and blood sugar (BS), and neurological symptoms caused by acute tramadol poisoning. Therefore, requesting these tests during tramadol poisoning should be reconsidered.

    Keywords: Hematological factors, Laboratory tests, Neurological finding, Seizure, Tramadol
  • Hassan Amiri, Sirous Panahi, Shirin Nasrolahnejhad Tasoj*, Fatemeh Kazemi, Shima Haghani, Mahsa Makouie Page 2
    Introduction

    Family caregivers play a large supportive role in the care of patients suffering from special conditions, such as trauma and stroke. This makes them to be at risks of variety of mental disorders such as anxiety and depression. Effective communication and nursing consulting can play an important role in managing anxiety and depression in family caregivers. The aim of this study was to investigate the effect of tele-counseling on the improvement of depression and anxiety in family caregivers of patients with trauma and stroke.

    Methods

    This is a clinical trial study with 80 caregivers of stroke survivors discharged from Hospital. Inclusion criteria included being the primary caregiver, over 15 years of age, lack of cognitive impairment (dementia and delirium), lack of mourning experience for the past 6 months, and patient care for at least 2 months at home. Study tools included Beck Anxiety and Depression Inventory. The data were analyzed using t test, Mann-Whitney U, Wilcoxon and ANOVA tests in SPSS software.

    Results

    In the experimental group, there was a significant decrease in levels of depression and anxiety of family caregivers of traumatic patients, but no significant difference was observed in the control group before and after the intervention.

    Conclusion

    Nursing telephone consulting reduced the level of depression and anxiety of family caregivers of traumatic patients. Therefore, the development of desirable p

    Keywords: Telephone nursing counseling, Depression, Anxiety, Familycaregivers, Stroke, Trauma
  • Femoral mononeuropathy post kidney transplants a very rare surgical complication in kidney transplantation: A case report
    Afshar Zomorrodi, Kamaleddin Hassanzadeh* Page 3

    Kidney transplantation is accepted as the first choice treatment of chronic renal failure. While urologic complication is the most common surgical complication after kidney transplantation, femoral nerve injury is very rare, which in our department with 1500 kidney transplantation experiences between 1992 and 2019, we had only two reported cases of femoral mononeuropathy. A 55 years old woman with a duration of 4 years’ dialysis (her donor was her son) and a female with the age of 45 years and duration of 3 years’ dialysis (her donor was a cadaver) instantly after kidney transplant operation symptoms of femoral nerve injury were detected, which were the loss of knee jerk reflex, reduced resistance of knee and not being able to give the flexion position to the knee when standing or walking. The femoral nerve injury may be self-limited and it looks preventable with a careful handling of the pelvic iliac artery and gentle placement of the retractor and less time of ischemic and careful hemostasis.

    Keywords: Kidney transplantation, Femoral nerve, Nerve injury, Case report
  • A case report of Fahr’s disease presenting with cerebellar ataxia
    Mohammad Yazdchi, Ramin Khanalizadeh, Nasrin Forghani, Zahra Jalali, Mahnaz Talebi* Page 4

    Fahr’s disease is a rare condition characterized by the symmetrical calcification of basal ganglia and dentate nuclei of the cerebellum calcification. It is usually manifested by involuntary movements and psychiatric symptoms. Ataxia has been reported as an uncommon manifestation of Fahr’s disease. Herein we introduce a 41-year-old man presenting with progressive gait disturbance who was finally diagnosed with Fahr’s disease.

    Keywords: Fahr’s disease, Basal ganglia diseases, Ataxia, Idiopathic familial basal ganglia calcification
  • A review on statins with a focus on type 2 diabetes
    Vahideh Sadra, Mitar Niafar, Vahid Hosseini, Amir Mehdizadeh* Page 5

    Statins are the most important lipid lowering drugs and their protective effects in primary or secondary cardiovascular diseases (CVDs) have been well documented. However, various number of evidences have revealed that the beneficial effects of statins regarding the CVDs are not only due to their blood cholesterol lowering properties but also because of their pleiotropic effects such as inhibition of isoprenoids synthesis, immunomodulation and neuroprotection. Type 2 diabetes mellitus (T2DM) is a systemic disease with inflammatory properties and micro/macro-vascular complications. Despite the beneficial effects of statins to lower blood cholesterol level, mortality decrease due to CVD and stroke, dyslipidemia improvement, and their anti-inflammatory and anti-coagulatory properties have not well been studied, especially in T2DM. In this review, we discuss the pharmacology, pleiotropic effects, dose prescribing and side effects of statins with a focus on type 2 diabetes.

    Keywords: Diabetes mellitus, Statins, Hypercholesterolemia, Cardiovascular diseases, Inflammation, Coagulation factors
  • Comparison of liver elastography results in COVID-19 patients with and without increased liver enzymes
    Masood Faghieh Dinevari, Samaneh Abbasian, Masoud Hejazi, Ali Riazi* Page 6
    Introduction

     The coronavirus disease 20149 (COVID-19) may be associated with the elevated liver enzymes including alanine aminotransferase (ALT) and aspartate aminotransferase (AST), in which the disease has been associated with more severity. Liver stiffness (LS) is associated with the increased liver enzymes. Liver elastography is a non-invasive technique that is used to evaluate LS. This study aimed to evaluate the functional status of liver and its relationship with liver elastography results in the patients with COVID-19.

    Methods

     In this cross-sectional study, 90 patients with COVID-19, whose diagnosis was confirmed by polymerase chain reaction (PCR) test, were included. Levels of liver enzymes were measured and the patients underwent liver elastography. Liver size and interquartile range-median (IQR/M) of LS were also measured. Six months later, the patients underwent another liver elastography and measurement of liver enzymes.

    Results

     The frequency of fatty liver in the case group was significantly higher compared to the control group but no significant difference was observed in the frequency of liver fibrosis between two groups. In patients with COVID-19, the LS and IQR/M values at the beginning and six months after recovery were significantly higher in the group with the increased liver enzymes (case) compared to the group without the increased enzymes (control). P value was 0.001.

    Conclusion

     The use of elastography to evaluate LS in the patients with COVID-19 can be significantly effective in assessing the status of liver damage and inflammation of liver tissue. Since elastography is an inexpensive and non-invasive available tool, it can be used mainly in most medical centers.

    Keywords: Elastography, COVID-19, Liver cirrhosis, Liver diseases, Liver enzymes
  • Mohammad-Bassir Abolghassemi-Fakhree, Shahryar Hashemzadeh, Mehdi Farhoudi, Javad Mahmoudi, Monireh Halimi, Mohammad-Salar Hosseini, Maryam Omrani-Hashemi* Page 7
    Introduction

     Erythropoietin (EPO) is reported to have a minimizing effect on the ischemic condition, but the detailed association between EPO and the ischemic upshot is still not clearly understood. We aimed to evaluate the effect of EPO on inflammatory response and ischemic brain damage after carotid artery clamp in rats.

    Methods

     In this experimental, animal trial study, which was conducted at the Animal Facility and laboratory at Tabriz University of Medical Sciences, 50 adult male Wistar rats with (250 to 300 g) were randomly allocated to intervention and control groups. The intervention and control groups were administered intraperitoneally with equal volumes of EPO (5000 U/kg) and normal saline, respectively. Both groups had common carotid arteries clamped for 20 minutes. Using the Nissl staining technique, the slides of brain ischemic areas were observed and the rate of ischemic injury in both groups was determined. The blood level of inflammatory cytokines was also measured.

    Results

     The levels of inflammatory markers including creatine phosphokinase (CPK), interleukin (IL)-6, IL-1B and tumor necrosis factor alpha (TNF)-α in the intervention group were significantly lower than that of control group. Mean percentage of the ischemic area in the intervention group with an amount of 4.30±2.15%, was significantly lower than that of control group (11.20±2.35%, P=0.023).

    Conclusion

     Findings of this study showed that the injection of EPO before carotid clamping is effective in preventing cerebral ischemic injury in rats.

    Keywords: Erythropoietin, Ischemic brain damage, Carotid artery clamp, Rat
  • Waseem Hassan, Mahsa Rasekhian, Kayhan Azadmanesh, Aysa Rezabakhsh* Page 8
    Introduction

     The objective of the present report is to perform the first comprehensive bibliometric analysis of oncolytic virotherapy research publications.

    Methods

     Scopus was employed as a major database. The total number of publications was found to be 4369, majorly comprising of research articles (n=2895) and reviews (1082). The ANOVA F-test and Welch F-tests were performed to determine the significance (P=0.05).

    Results

     In all publications (3751), the total numbers of authors were 11418 and 10480 different organizations, departments or institutes. We specifically selected seven different viral strains and provided details about the co-authorship network. We also provided details about the top 10 most cited documents.

    Conclusion

     This may provide a quantitative overview about the trends and publications in oncolytic virotherapy research.

    Keywords: Bibliometric analysis, Countries, Institutes, Oncolytic, Publications, Virotherapy