فهرست مطالب

Eurasian Chemical Communications
Volume:5 Issue: 7, Jul 2023

  • تاریخ انتشار: 1402/04/10
  • تعداد عناوین: 7
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  • Seema Kasim, Noora Abdulaziz, Mahmood Jasim, Yasser Mustafa * Pages 576-587
    Cancer is a virulent disease that is regarded as a black-hearted and evil-minded illness in many human civilizations because it develops silently and without warning until it reaches a life-threatening stage. In the management of cancer, chemotherapy represents the principal option but has significant toxic effects that negatively influence the patient's physiology and psychology. To improve the chemotherapy efficacy, scientists proposed several adjuvant approaches, including the use of fighters with an additive effect that reduces the chemotherapeutic agent dose, and thus the occurrence of toxic effects, protectors to preserve normal tissues, and preventers by inducing apoptosis in cancerous cells as they develop. It seems that nature can provide these adjuvant agents with high quality. Resveratrol is one of the most studied natural agents due to its promising effects in cancer treatment. This review aimed to highlight these effects based on exploring the most recent information concerning this natural polyhydroxy product. The authors concluded that resveratrol can act as a potential chemotherapy alleviator by inhibiting carcinogenesis and many of its initiating enzymes and proteins, modulating many chemotherapy-related toxic effects, and potentiating the toxic effects inside cancerous cells via multiple pathways.
    Keywords: Resveratrol, Chemopreventer, Chemoprotector, Chemofighter, cancer, Chemotherapy
  • Murtadha Najim, Qais Lahhob *, Hamid Abbas, Haider Alidrisi, Zahraa Ibrahim, Zainab Budaiwi, Zainab Abdul-Jabbar, Mustafa Kadham, Majid Maatook Pages 588-597
    Apelin is an adipocytokine secreted from adipocytes. Although much research has been conducted on apelin, no or few reports are there about its association with atherogenic indices in patients with thyroid dysfunctions. The aim of this study is to investigate the association between serum apelin and atherogenic indices. A total of 177 participants were included in the current study (43 controls and 124 patients with thyroid dysfunction). Serum apelin and lipid profile tests were determined and atherogenic indices were calculated for each participant. Higher concentrations of Apelin level in hyperthyroidism were compared with control groups and hypothyroidism. All types of an atherogenic indices indicated a significant increase in hypothyroidism more than hyperthyroidism and control groups, the atherogenic indices (AIP, CRI-I, CRI-II, AC, and Chol indices) had more diagnosis accuracy than apelin in a diagnosis of hypothyroidism group, despite of that apelin had more diagnosis accuracy than atherogenic indices (AIP, CRI-I, CRI-II, AC, and Chol indices) in a diagnosis of hyperthyroidism group. The apelin was significantly increased in hyperthyroidism compared with hypothyroidism.
    Keywords: apelin, atherogenic, hyperthyroidism, hypothyroidism diagnostic accuracy, Dyslipidemia
  • Abdulwadood Ibrahim Arif * Pages 598-608
    In the present study, nanoparticles of copper oxide were formed using a green approach. The Biosynthesis of CuO NPs was fabrication with the help of fungi which isolated from rot vegetables. The extract of Aspergillus niger fungi and Copper(II) chloride were used to synthesize bio-CuO NPs. Different techniques such as XRD (X-ray diffraction), FE-SEM (Field emission scanning electron microscopy), FTIR (Fourier transform infrared spectroscopy), and UV-Vis (UV–visible spectroscopy) were utilized to characterize and identify the biosynthesis of CuO NPs. The bioactivity of bio-CuO was screened against some types of pathogenic bacteria including Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Salmonella typhimurium via MHA (Muller Hinton agar) media. The results show that bio-CuO NPs have a potential effect against bacteria used in the current study and are more active toward Escherichia coli and Salmonella Typhimurium compared to other types. The antioxidant activity of bio-CuO was further studied in a dose-dependent manner. The obtained results show a positive effect of bio-CuO NPs and the activity increase when concentration is increased. Therefore based on the obtained results, the bio-CuO NPs have promising applications in the field of biomedical, industrial, and biological applications.
    Keywords: Biosynthesis of CuO, Aspergillus niger, Pathogenic bacteria, Antioxidant activity
  • Hussein Kareem, Ibrahim Jihad, Hussein Hassan, Mohammed Znad, Mariam Harbi, Qais Lahhob *, Mustafa Kadham, Mohammed Hamzah, Abdulrahman Jasim Pages 609-615
    The coronavirus disease 2019 (COVID-19) pandemic has introduced attention to request for various diagnostic strategies, comparative validation of novel tests, quicker federal agency clearance, and quick manufacture of test kits to satisfy worldwide demand. Thus, this study was aimed to investigate biochemical and hematological variables in COVID-19 positive patients, so as to act early and improve patient outcomes. 34 patients with COVID-19 patients were diagnosed at Rifai General Hospital, Dhi Qar Health Directorate, during the period of (15 September 2020 to March 2021) in this study with two study group, as group one (i.e. the first week infection) and group two (i.e. the second week infection). The reagents kits for Random Blood Sugar (RBS) were used, and also urea, and creatinine measurements were done by spectrophotometry method (Biolabo/France), whereas D-dimer measurement was performed by )MAGLUMI 1000-China), Complete Blood Count measurement was conducted by XP-300™ Automated Hematology Analyzer System Device, USA. In this study, it was found that WBC had a significant difference (p-value 0.05) based on the comparison between the two groups, whereas RBS and creatinine had no significant difference (p-value>0.05) and urea and D-dimer had a significant difference (p-value 0.05) when compared between the two groups. The D-dimer and urea levels were significantly increased in the second group compared with the first group of the patients.
    Keywords: COVID-19, D- Dimer, (CBC), RFT
  • Hayder Hussain Ali *, Wathiq Abdul-Hassan Pages 616-641
    Cobalt(II) complexes: CoA and CoACl are synthesized. Treatment of CoA with 10 equivalents of 4,4-bipyridine (Bpy) in acetone afforded adduct complex CoA-Bpy. These three cobalt(II) complexes are characterized by FT-IR, mass and UV-Visible absorption spectrometries besides thermal and XRD analysis. The interactions of the complexes CoA and CoACl with Bpy to afford the adduct complexes are studied by UV-Visible absorption spectrometry. The interactions of the complexes CoA and CoACl with propylene linked bis-viologen (V2+A2.2PF6-) yield the adduct complexes coordination of V2+2.2PF6- to cobalt(II) ion within cobalt(II) complexes. Then, switching motion of V2+2.2PF6- coordinated to Co(II) ion was triggered by two electrons reduction.
    Keywords: acetylacetone, Cobalt complexes, adduct viologen, π-dimer
  • Nadia Sadiq Majeed *, Rasha Neama Hussein Pages 642-660
    A series of some new heterocyclic six–membered compounds has been synthesized from Flucytosine drug, containing a terminal primary amine group, and was used to prepare a number of new Schiff base compounds bearing the numbers (A1-A4) through interaction with different aldehydes and ketones and using ethanol absolute as a solvent. After that, it was possible to prepare several organic compounds using Schiff bases (A1-A4) prepared in the first step, which contain azomethine group react with (2-aminobenzoic acid and 2-mercaptobenzoic acid) to prepare hydroqinazoline (A5-A8) and thiazinone derivatives (A9-A12). These reactions are followed by TLC and the measurement of melting points for the derivatives. These compounds were determined by FT-IR and by 1H-NMR and 13C-NMR spectra, along with studying the biological activity of the prepared derivatives.
    Keywords: Flucytosine, Schiff bases, Hydroqinazoline, Thiazinone, Biological activity
  • Nabi Javadi *, Hossein Fakhraian Pages 661-674
    In this paper, the ability of organic reagents such as the succinate, oxalate, maleate, fumarate, adipate, glutarate, suberate, and pimelate anions in separation of different enantiomer form of tiletamine compound (R&S) is investigated using the density functional theory method (DFT). Our findings showed that the conglomerate crystal of tiletamine is formed in the presence of succinate, oxalate, fumarate, and maleate organic reagents. Moreover, the racemic mixture of tiletamine is formed in the presence of adipate, glutarate, suberate, and pimelate anions. According to the thermodynamic parameters of tiletamine-organic anion interactions, it is revealed that, in comparison to chloroform, internal thermal energy, enthalpy, and Gibbs free energy become more positive in the presence of ethanol and water solvents indicating the enfeeble effect of solvent polarity on enantiomer separation. Also, it should be noted that the existence of carbon chain lengths greater than three atoms in the organic anion is not suitable for enantiomeric separation. The natural bond orbital (NBO) and Atom In Molecules (AIM) results show that tiletamine nitrogen atom is the primary site of interaction with the oxalate, succinate, fumarate, and maleate anions.
    Keywords: Tiletamine, enantiomer separation, thermodynamic parameters, conglomerate crystal, Organic Reagent