فصلنامه طب مکمل
سال سیزدهم شماره 1 (پیاپی 46، بهار 1402)

Cuscuta chinensis L. is a widely used medicinal plant with little data on its standardization. This study aims to contribute to the efficiency and safety of its use by preliminary investigation on its physicochemical and phytochemical characteristics.

The extract was concentrated at low temperature to prepare a dry powder. Sensory evaluation was used to determine the organoleptic characteristics. Then the percentage of total ash, ash insoluble in acid and dry residue was measured by Pharmacopeia method. Total phenol and total flavonoid content as well as rutin content were measured by HPLC spectroscopic methods. The total number of microbes and the presence of the main pathogens were also investigated.

The dried aqueous extract of C. chinensis was a powder with a brown color, herbal odor, the amounts of total ash and acid insoluble ash were28.16, 9.1%, respectively, and the amount of dry residue was 05.7%. The amount of total phenol content was 55.61 ± 9.02 mg Gallic acid/g and the amount of total flavonoid was 25.27 ± 1.2 mg Catechin/g. The total number of live bacteria, fungi, and yeast was less than 10 cfu/ml, and the sample did not contain the main pathogens under investigation.

The results of this study provide data on some physicochemical properties of C. chinensis extract that were not available in other resources. However, in order to achieve accurate standardization criteria, more information is needed, which can be obtained from more extensive research.

Lemon balm is a widely used medicinal plant, but in addition to the main variety (Melissa officinalis L.), several other plant species are sold in the pharmaceutical markets with the name of lemon balm, it’s properties, type and concentration of medicinal compounds are not completely similar to the original variety, therefore. It is important to investigate these species more closely and determine their botanical indicators, therapeutic properties and possible side effects.

This research has been carried out in two dimensions: studying valid research documents and conducting field research, in the first dimension, in addition to the study of flora related to the search in Pubmed, Webmed, Scopus, Magiran and... Databases with the key Persian words such as Badranjbuiyeh (Lemon Balm), therapeutic properties, side effects, local name and their English equivalents were also found in related published articles. In the second dimension, the samples that were offered under the name Badranjbouyeh in different parts of the country were purchased and identified after being transferred to the herbarium.

Based on the identified samples, it was found that in addition to Melissa officinalis L. species; at least 15 other plant species are sold in the country under the name of lemon balm. Dracocephalum polychaetum, Dracocephalum ,moldavica Dracocephalum Surmandinum, Dracocephalum subcapitatum, Dracocephalum kotschy Dracocephalum Lindbergii, Dracocephalum aucheri, Hymenocrater elegans, Hymenocrater Bituminosus (Dracocephalum thymiflorum Stachys inflata, Nepeta persica Nepeta mahanensis, Marrubium vulgare ( of Lamiaceae and Asperugo procombens of Boraginaceae.

The lack of expertise in botanical science of many suppliers of medicinal plants leads to the occurrence of inadvertent frauds in the market of medicinal plants, these frauds, in addition to reducing the effectiveness of treatment, can lead to severe side effects or damage, therefore, it is very important to accurately identify the types of drugs available in the country's drug market.

New research indicate that even a mild level of depression are associated with a significant decrease in the quality of life in adults. Therefore, the existence of a natural, simple, accessible and cost-effective treatment method is needed by every person suffering from depression. The purpose of this research is to compare the effectiveness of Ayurvedic knowledge, as a complementary medicine, with cognitive-behavioral therapy and also to examine the combination of these two therapies on the quality of life in depressed women.

The research was a semi-experimental pre-test-post-test type with a control group. The statistical population includes 40 women aged 45-25 who were diagnosed with moderate depression by a psychiatrist and took the Beck depression test & by filling and signing the informed consent form, they expressed their consent to participate in the study and volunteered to participate in this research. They underwent cognitive-behavioral therapy, Ayurveda and combination of the two for 10 weeks based on the protocols. Data collection tools included World Health Organization quality of life questionnaire - short form. The data were analyzed using repeated measurement tests.

The average scores of the variable quality of life of depressed women in the Ayurvedic intervention group were 52.3 ± 5.33 before treatment and 54.1 ± 5.04 after treatment, and no significant difference was observed between them (P = 0.12). Treatment with cognitive-behavioral approach, before treatment was 43.7 ± 16.95 and after treatment was 54.95 ± 13.51, no significant difference was observed (P = 0.26) But in combined treatment before treatment was 61.8 ± 11.84 and after treatment it was 54.8 ± 7.73, So the difference between the average score in this method was significant (P = 0.038).

Considering the adverse effects of depression on the quality of life of women, the combination of Ayurveda as complementary medicine and cognitive-behavioral therapy can be beneficial in improving the quality of life in depressed women.

Adolescence is one of the sensitive and important stages of human development, and the presence of diabetes in adolescents has many complications, one of which is insomnia. Spiritual care, especially for teenagers, along with routine care, can affect and improve their quality of life by dealing with stress.

The present study is a randomized clinical trial study, which was carried out by a simple random allocation method of pre-test and post-test type on 66 diabetic adolescents (33 in the test group, 33 in the control group) aged 12 to 20 years, referring to urban comprehensive health service centers and Village of Qaimshahr in 1401 after obtaining consent and ensuring the confidentiality of the received information. The data collection tool was the ISI Insomnia Severity Questionnaire. The test group was taught White's spiritual self-care during 6 sessions of 30 to 45 minutes. At the end, the data was entered into spss22 software and then the information was analyzed by descriptive statistics and inferential statistics.

The average intensity of insomnia in the test group before the intervention was 19.91±1.4 and in the control group was 20.88±2.57 and after the intervention in the test group it was 18.45±2.18 and in the control group reached 20.45±1.34, a significant difference was seen. With analysis of variance by removing the effect of the pre-test, a significant difference was observed.

Based on the results of the study in diabetic adolescents, spiritual self-care training improves the severity of insomnia. It is suggested that this study be followed up in the long term.

Relieving pain in newborns is one of the main goals of nursing care, and in this context, non-pharmacological methods of pain relief have always been of interest to nurses. The aim of this study is to investigate the effect of non-nutritional sucking and mother's voice on venous blood sampling pain in newborns.

In this randomized clinical trial, 105 newborns aged 3 to 10 days with neonatal jaundice were selected using the available method. They were randomly divided into three groups including non-nutritional sucking, mother's voice and control groups. The procedure was as follows; during venous blood sampling, video was taken for all three groups, and then the severity of pain during blood sampling was evaluated by reviewing the video and filling in the newborn pain questionnaire. Data analysis was done using SPSS version 26 and chi-square test, Fisher's exact test, Kruskal-Wallis test and Ben Feroni pairwise comparison.

The results showed that the average pain score in the non-nutritional sucking group (3.20 ± 2.33) was significantly lower than the control group (5 ± 2.22) (P = 0.006). But the average pain score in the mother's voice group (4.06 ± 2.49) and the control group (5 ± 2.22) has no significant difference (P = 0.393). Also, the average pain score between the non-nutritional sucking group (3.20 ± 2.33) and the mother's voice group (4.06 ± 2.49) has no statistically significant difference (P = 0.291).

The use of non-nutritive sucking significantly reduced the pain caused by blood sampling in newborns. Of course, considering that there was no difference in the two groups of mother's voice and non-nutritive sucking, mother's voice can also be used in some cases.

The aim of this research was to investigate the effect of eight weeks of aerobic training and coriander seed extract with two doses of 5 and 10 mg on oxidative stress markers and cardiac muscle ATP levels of rats poisoned with hydrogen peroxide.

42 healthy adult male rats were randomly divided into 7 groups. During one week, the groups were poisoned intraperitoneally by receiving 100 mg/kg of hydrogen peroxide. In the following, the target groups were subjected to intervention on the treadmill for eight weeks (5 sessions of 60 minutes per week) with doses of 5 and 10 mg per kilogram of coriander seed extract. At the end, the concentration of ATP, MDA and PAB indicators was measured using ELISA method.

The results of analysis of variance test showed the decreasing effect of aerobic exercise on MDA and PAB values (P<0.05), while it had no significant effect on ATP concentration (P>0.05). On the other hand, consumption of two doses of coriander seed extract had no significant effect on the prooxidant-antioxidant balance (P>0.05), while their consumption caused a significant increase in ATP concentration (P<0.05).

Despite the fact that eight weeks of aerobic exercise is considered a suitable solution for modulating the changes in oxidative indices caused by hydrogen peroxide poisoning, this intervention does not have a significant effect on the amount of myocardial cellular energy. On the other hand, the effects of coriander seed extract are probably dose-dependent in some cases.

Information about the use and attitude of medical students towards complementary medicine is needed to determine its place in conventional medicine. The aim of this study was to determine the attitude and use of complementary medicine in general and specialized doctoral graduates of Mazandaran University of Medical Sciences.

I n this descriptive-analytical study, the attitudes of medical graduates were determined with a 23-item questionnaire and the use of 17 complementary medicine methods with a checklist, and the level of satisfaction at four levels. Quantitative variables were analyzed with ANOVA and qualitatively from Chi 2.

The attitude score of 276 participants in this study was 73 ± 9.2 (39 to 79). There was no statistical difference between the attitudes of the four educated groups (p=0 .436). 80 people (29%) believe that complementary medicine treatment methods are placebo effect and 103 people (37.3%) believe that there is no scientific evidence for the safety of complementary medicine use. 66 people (23.9%) had a positive attitude towards complementary medicine and 23 people (8.4 percent) had a negative attitude, 91 people (33 percent) used at least one of the complementary medicine methods. The most common method of massage therapy was 33 people (12 %). 38(41.8 %) people of the users of massage, acupressure, meditation and energy therapy methods had good satisfaction.

A quarter of doctoral students had a positive attitude towards complementary medicine methods. Considering the widespread use of complementary medicine methods by people in different societies of the world and the interference of these methods with conventional medicine in the matter of care and treatment. It is recommended to develop a curriculum and research program to familiarize and improve the attitude of all students of medical sciences towards complementary medicine methods.