فهرست مطالب

Journal of Applied Organometallic Chemistry
Volume:3 Issue: 2, 2023 Jun

  • تاریخ انتشار: 1402/03/11
  • تعداد عناوین: 6
|
  • Rajesh Das *, Deboshmita Mukherjee, Sahin Reja, Kaushik Sarkar, Ambica Kejriwal Pages 73-85
    The N3 tridentate ligand N,N-dimethyl-N-(1-pyridinylmethylidene) propane-1,3- diamine (DPMPD) and its copper complex (CDPMPD) were synthesized of which metal complex is found  in green colour  powdered form. The associated spectroscopic techniques were used to characterize both ligand and the metal complex. Powder XRD method was utilized using the Scherrer formula to accomplish the grain size of the metal complex. It was found that the experimental results of the powdered complex were quite similar to that of the reference material with JCPDS ID 00- 024-1977. In vitro anticancer activity shows that the metal complex exhibits a moderate cytotoxic effect on Hep-G2 cell line. This cytotoxic phenomenon is well supported by a molecular docking study using target topoisomerase II crystal structure (PDB id 4FM9). The HOMO- LUMO energy gap, predicted from the DFT study, signifies that the complex is susceptible to chemically reactive.
    Keywords: DPMPD, CDMPD, anticancer activity, DFT, Docking
  • Muhammad Khalil, Shaista Noor, Zaheer Ahmad, Fawad Ahmad * Pages 86-107

    Fruits include nutrients that are essential for good health as well as body repair. Heavy metals occur spontaneously in the environment as a result of natural sources and anthropogenic activities or contamination through industrial operations, preservation, including cooking. Pesticide pollution is a worldwide environmental and public health hazard since pesticides are carcinogenic and extremely poisonous among all living species, especially plants, animals, even people. Pakistan, an agricultural-based country, uses a large quantity of such organochlorine-pesticides (OC) each year to manage insect pests and various crop diseases, which is health risk. However, contemporary statistics on pesticide usage, pollution, and exposure in Pakistan are mainly missing. This study highlights recent findings and gives statistics on pesticide usage and pollution, with a special emphasis on human exposure. Mango considered one of Pakistan's most important fruit crops, yet it is facing threat from the World Trade Organization (WTO). To that end, the current study was carried out to examine agricultural extension programs in mango marketing and production with specific reference to the WTO. It was discovered that respondents' knowledge of the different WTO agreements was inadequate, and in certain cases non-existent. According to respondents, the positive influence of WTO would be beneficial in providing refined products at the customer’s doorstep and reliable to human and environmental life, but the primary threat of cumulative authority over marketplaces by developed nations through their better technology and very well-equipped industry, related specifically to mango fruit and its byproducts.

    Keywords: Toxicity, Mango, Organochlorine-pesticides, Organophosphates
  • Md Riajul Islam Sardar, Fardaush Hasan, Md. Jone Alam, Imam Hossain Nadim, Md. Mahmud * Pages 108-122
    Furfural, an environmentally friendly alternative to petroleum-derived products, has gained significant attention as a versatile and sustainable chemical. This review article presents a critical analysis of state-of-the-art processes and technologies for furfural production from lignocellulosic biomass, focusing on bioremediation and biochemical development potential. It includes a comprehensive overview of biomass pretreatment techniques, advanced hydrolysis techniques, and highly efficient furfural synthesis methods. Recent research advances are synthesized, research gaps are identified, and future research directions are pointed out. The paper discusses various production methods including acid hydrolysis, catalytic systems, solvent-thermal conversion, and bio-refinery processes. Process steps for each approach, reaction status comparisons, and key findings are highlighted. The results obtained from the tests on parameters such as temperature, pressure, pH, and substrate concentration are consistent, with temperature being identified as an important factor affecting furfural production. In addition, this comprehensive review investigates the effects of pressure, pH, and substrate concentration on furfural production and will serve as a valuable resource for researchers, industry professionals, and policy makers involved in furfural production. It provides insight into the current status of furfural production from lignocellulosic biomass and emphasizes opportunities for process acquisition, improvement, and optimization. Ultimately, this review article will contribute to the development of a greener and more sustainable bio-based economy.
    Keywords: Furfural, Lignocellulosic biomass, Acid Hydrolysis, Catalysts, Chemical manufacturing
  • Rosa Khazaei *, Ardeshir Khazaei, Mahmoud Nasrollahzadeh Pages 123-133
    Fe3O4@SiO2-Pd nanocatalyst was successfully synthesized from Horsetail plant (Equisetum arvense) that provides biosilica. The synthesized Fe3O4@SiO2-Pd nanocatalyst was characterized by Fourier transform infrared, XRD, SEM, EDAX, and VSM measurements. In the Suzuki coupling process, the Fe3O4@SiO2-Pd nanocatalyst's effectiveness as a catalyst was also examined. The products were characterized by NMR. The main advantage of this method is small reaction time, high percentage yield, use of natural materials, low catalyst loading, simple experimental procedure, easy work, and cleaner. This catalyst was highly recyclable and was recovered in a facile manner by employing an external magnet and reusing it several times.
    Keywords: Suzuki coupling reaction, Green synthesis, Fe3O4@SiO2-Pd nanocatalyst, Horsetail
  • Hoda Banary *, Eskandar Kolvari, Parvin Hajiabbasi Tabar Amiri Pages 134-141
    A simple and efficient method for synthesis of 1,2-disubstituted benzimidazoles has been developed by a one-pot reaction of o-phenylenediamine with aryl aldehydes in the presence of sodium lauryl ether sulfate (SLES) in aqueous medium at ambient temperature without any organic solvent. The optimum SLES loading was observed at 15 mol%. The procedure is simple and the expected benzimidazole compounds were isolated in good yields. The present method provides the advantages of convenience, energy-saving eco-friendliness, mild reaction conditions, and no use of hazardous solvents.
    Keywords: Sodium lauryl ether sulfate, o-Phenylene diamin, Benzaldehyde, 2-Disubstituted benzimidazoles
  • Saroj Sharma * Pages 142-155

    This review provides a concise overview of the past, present, and future applications of ferrocene and its derivatives in drug discovery. Ferrocene-based compounds have shown promise in various therapeutic areas, including cancer, infections, and inflammation. Despite challenges in solubility and bioavailability, recent advancements in synthesis and formulation have improved their drug-like properties. The unique redox properties of ferrocene offer opportunities for targeted therapies, while combination strategies and drug delivery systems enhance their efficacy. The emerging field of metallopharmaceuticals further expands the potential of ferrocene-based drugs. Continued research in this area holds promise for the development of innovative and effective therapeutic agents.

    Keywords: Metallopharmaceuticals, Ferrocene, therapeutic